Navigation Links
Gene found to be crucial for formation of certain brain circuitry
Date:12/5/2013

Using a powerful gene-hunting technique for the first time in mammalian brain cells, researchers at Johns Hopkins report they have identified a gene involved in building the circuitry that relays signals through the brain. The gene is a likely player in the aging process in the brain, the researchers say. Additionally, in demonstrating the usefulness of the new method, the discovery paves the way for faster progress toward identifying genes involved in complex mental illnesses such as autism and schizophrenia as well as potential drugs for such conditions. A summary of the study appears in the Dec. 12 issue of Cell Reports.

"We have been looking for a way to sift through large numbers of genes at the same time to see whether they affect processes we're interested in," says Richard Huganir, Ph.D., director of the Johns Hopkins University Solomon H. Snyder Department of Neuroscience and a Howard Hughes Medical Institute investigator, who led the study. "By adapting an automated process to neurons, we were able to go through 800 genes to find one needed for forming synapses connections among those cells."

Although automated gene-sifting techniques have been used in other areas of biology, Huganir notes, many neuroscience studies instead build on existing knowledge to form a hypothesis about an individual gene's role in the brain. Traditionally, researchers then disable or "knock out" the gene in lab-grown cells or animals to test their hypothesis, a time-consuming and laborious process.

In this study, Huganir's group worked to test many genes all at once using plastic plates with dozens of small wells. A robot was used to add precise allotments of cells and nutrients to each well, along with molecules designed to knock out one of the cells' genes a different one for each well.

"The big challenge was getting the neurons, which are very sensitive, to function under these automated conditions," says Kamal Sharma, Ph.D., a research associa
'/>"/>

Contact: Shawna Williams
shawna@jhmi.edu
443-903-7607
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. A hallmark for the development of testicular tumors found in the aberrant regulation of small non-coding RNA
2. E.O. Wilson Biodiversity Foundation moving to Duke
3. Wellspring Biosciences Founder Publishes In Nature On Discovery of Small Molecule Inhibitors of K-Ras
4. Novel gene variant found in severe childhood asthma
5. Fossil of new big cat species discovered; oldest ever found
6. Carbon dioxides new-found signalling role could be applied to blood flow, birth and deafness
7. Evidence of 3.5 billion-year-old bacterial ecosystems found in Australia
8. New cause found for muscle-weakening disease myasthenia gravis
9. SIGNAL found to enhance survival of new brain cells
10. Cause of genetic disorder found in dark matter of DNA
11. Earliest marker for autism found in young infants
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene found to be crucial for formation of certain brain circuitry
(Date:4/17/2015)... Canada , April 17, 2015 ... growing security concerns, and technological advancement to drive ... until 2020   According ... Saudi Arabia Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric systems ... is projected to register growth at CAGR of ...
(Date:4/14/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces that its Wocket® smart ... Design Awards under the category  ,Product Design – Technology,. ... are part of a global multi-disciplinary awards program. The ... marketplace, industry and judging panel. Winners will be announced ...
(Date:4/13/2015)...  higi, a leading cloud-based consumer engagement platform that ... with their communities around health and wellness, announced today ... API.  ... and convenient vehicle to receive validated health information from ... The API will allow higi,s trusted partners, on a ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
... mulch offers a range of benefits and has become ... horticultural crops. Despite the recognized benefits, the plastic mulches ... be used for only one cropping season, after which ... and time-consuming processes for growers. The challenges and costs ...
... cities: safety, ready availability of infrastructure, plenty of company ... for the benefits of country life, such as clean ... and particularly birds, face the same choice between living ... avoiding disadvantages of larger colonies such as the increased ...
... stage medical device company founded by students at The ... at the Texas Life Science Forum as one of ... having the best business opportunity and promise for high ... competed in the event on Thursday, February 20 in ...
Cached Biology News:Study finds 2 biodegradable mulches to be suitable polyethylene alternatives 2The importance of (experimental) design 2The importance of (experimental) design 3Leto Solutions honored as 1 of top 10 best companies at 2014 Texas Life Science Forum 2Leto Solutions honored as 1 of top 10 best companies at 2014 Texas Life Science Forum 3
(Date:5/21/2015)... , May 21, 2015 ... inner feelings - and those of others. Being able ... senses. Analyze and read people to anticipate their thoughts ... your deepest emotions and feelings to create unique abstract ... of responsive games. Get inside a first-person-shooter as it ...
(Date:5/21/2015)... May 20, 2015 Research and Markets ... of the "2015 Global Survey on Flow ... The primary goal of this research ... instruments and reagents. Key information the survey seeks ... of flow cytometers, predominantly used applications for flow ...
(Date:5/20/2015)... , May 20, 2015 Research and Markets ... the "Top Technologies in HW_Technical Insights" report ... this report evaluated technology trends in the Health and ... are likely to have an impact in the year ... of the top 10 health and wellness technologies that ...
(Date:5/20/2015)... May 20, 2015  Health eCareers, the healthcare ... organizations with job seekers looking for the flexibility ... new mobile and online tool dedicated exclusively to ... SHIFT enables employers to quickly find ... nursing, per diem and other temporary positions, eliminating ...
Breaking Biology Technology:5 Days to Meet ARGUS - The World's First Contactless Emotions Scanner 2Global Survey on Flow Cytometry Adoption Trends 2015 2Top Technologies in the Health and Wellness Industry 2015 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 3
... Mano Receive 2008 JCA-Mauvernay Award, LAUSANNE, ... global biopharmaceutical development specialist that,focuses on serious ... Ichijo and Hiroyuki Mano with the 2008 ... research work in oncology.,The Awards were presented ...
... Preclinical Animal Data Demonstrates Selective Survival Advantage of ... Reduced Viral Loads, WASHINGTON and RICHMOND, Calif., ... ) announced today the presentation,of data demonstrating that ... HIV infection by treatment with zinc finger DNA-binding,protein ...
... Growth in Core ... Clinical Business, SUNNYVALE, Calif., Oct. 28 ... of $44.9,million, an increase of 24% over the third quarter of fiscal ... revenue of $36.3,million and a net loss of $4.7 million, or $(0.09) ...
Cached Biology Technology:Japanese Cancer Association and Debiopharm Honour Japanese Research 2Japanese Cancer Association and Debiopharm Honour Japanese Research 3Sangamo BioSciences Presents Data at ICAAC Demonstrating 'In Vivo' Protection Against HIV Infection by CCR5-ZFN Therapeutic 2Sangamo BioSciences Presents Data at ICAAC Demonstrating 'In Vivo' Protection Against HIV Infection by CCR5-ZFN Therapeutic 3Sangamo BioSciences Presents Data at ICAAC Demonstrating 'In Vivo' Protection Against HIV Infection by CCR5-ZFN Therapeutic 4Sangamo BioSciences Presents Data at ICAAC Demonstrating 'In Vivo' Protection Against HIV Infection by CCR5-ZFN Therapeutic 5Cepheid Reports Third Quarter Revenue of $44.9 Million 2Cepheid Reports Third Quarter Revenue of $44.9 Million 3Cepheid Reports Third Quarter Revenue of $44.9 Million 4Cepheid Reports Third Quarter Revenue of $44.9 Million 5Cepheid Reports Third Quarter Revenue of $44.9 Million 6Cepheid Reports Third Quarter Revenue of $44.9 Million 7Cepheid Reports Third Quarter Revenue of $44.9 Million 8Cepheid Reports Third Quarter Revenue of $44.9 Million 9Cepheid Reports Third Quarter Revenue of $44.9 Million 10Cepheid Reports Third Quarter Revenue of $44.9 Million 11Cepheid Reports Third Quarter Revenue of $44.9 Million 12Cepheid Reports Third Quarter Revenue of $44.9 Million 13
Mouse Anti-Amyloid beta [1-16], clone 6E10, Monoclonal Antibody...
The pCDF Expression System 1 plus Competent Cells contains 10 µg of pET-45b(+) DNA. pET-45b carries an N-terminal His•Tag ® coding sequence that is cleavable with enterokinase as well...
Nucleobindin 1 [NUCB1]...
Request Info...
Biology Products: