Navigation Links
Gene-environmental interactions and MS progression is focus of new study
Date:9/21/2010

BUFFALO, N.Y. -- A $634,000 grant from the Department of Defense is allowing researchers at the University at Buffalo to investigate a trio of environmental factors and their influence on the progression of multiple sclerosis.

The two-year project, headed by Murali Ramanathan, PhD, tests the hypothesis that nicotine metabolism, the byproducts of vitamin D metabolism and increased levels of anti-Epstein-Barr virus (EBV) each interact with variations in specific genes to cause increased neurodegeneration and increased lesions in MS patients.

Ramanathan is a professor of pharmaceutical sciences and neurology in the School of Pharmacy and Pharmaceutical Sciences and the School of Medicine and Biomedical Sciences, respectively.

The study is a collaboration between the UB and investigators from Charles University in Prague, Czech Republic, and will be conducted on samples obtained at both universities' MS centers.

The research aims to identify gene-environmental interactions between key molecules in the vitamin D pathway, anti-Epstein-Barr virus antibodies, cigarette smoking and key genetic variants that are implicated in conversion of patients with clinically isolated syndrome (CIS) to definite MS.

They will assess the risk of developing clinically definite MS and the time to progression, as well as the neurodegeneration in the brain of MS patients, as measured by brain atrophy, and the extent of brain injury caused by lesions.

"We will use a novel approach to measure the levels of vitamin D and its metabolites, EBV exposure and nicotine metabolites from cigarette smoking," says Ramanathan. "We have developed sensitive and selective measurements for key metabolites in the vitamin D and nicotine metabolism pathways using mass spectrometry, a method that has not been used previously to study vitamin D metabolism.

The novel study design will include the genetic variations that were associated with the risk of developing MS, as well as genes that determine the levels and responses to environmental factors. MS patients will be divided into two equal groups: a training group that will be used to identify gene-environmental interactions, and a group that will be used to replicate the training group result.

"Identifying gene-environmental interactions is critical for developing better strategies for slowing the progression of MS, because it could enable patients with preexisting genetic risk factors to reduce the rate of disease progression through lifestyle modification," Ramanathan says.

The study results will identify the gene-environment interactions that promote disease progression in MS and facilitate the development of preventive and therapeutic interventions for MS that disrupt these interactions, notes Ramanathan.


'/>"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-4606
University at Buffalo
Source:Eurekalert

Related biology news :

1. Photonic crystal biosensors detect protein-DNA interactions
2. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
3. New method provides panoramic view of protein-RNA interactions in living cells
4. Social interactions can alter gene expression in the brain, and vice versa
5. Researchers unzip molecules to measure interactions keeping DNA packed in cells
6. Research explores interactions between nanomaterials, biological systems
7. New windows opened on cell-to-cell interactions
8. Interactions with aerosols boost warming potential of some gases
9. Method of the future uses single-cell imaging to identify gene interactions
10. Protein-bait interactions, display libraries featured in Cold Spring Harbor Protocols
11. MicroRNA network study implicates rewired interactions in cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/11/2017)...  Michael Johnson, co-founder of Visikol Inc. a company originally funded ... named to the elite "Forbes 30 Under 30" list in the ... in 20 fields nationwide to be recognized as a leader in ... selected. ... currently a PhD candidate at Rutgers University. ...
(Date:1/4/2017)...  For the thousands of attendees at this year,s International Consumer Electronics ... and biometric measurement devices and services, will be featuring its new line ... A&D Medical,s special CES Exhibit Suite , the new upper arm ... company,s WellnessConnected product platform.  ... ...
(Date:12/22/2016)... 2016 SuperCom (NASDAQ:   ... the e-Government, Public Safety, HealthCare, and Finance sectors announced today that ... selected to implement and deploy a community-based supportive services program to ... , further expanding its presence in the state. ... This new program, which is ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... ... 2017 , ... DaVita Clinical Research (DCR), a ... device development, and Prism Clinical Research , a leader in providing fully ... Clinical Trials (VCT) has been selected by both companies as an exclusive ...
(Date:1/18/2017)... Portland, OR (PRWEB) , ... January 18, 2017 ... ... modules that provide essential device-to-computer interconnect using USB or PCI Express, announced the ... Altera Cyclone V E FPGA into a compact business-card sized form factor suitable ...
(Date:1/18/2017)... ... , ... Executive search firm Slone Partners proudly supports the ... advancement of the clinical trials segment. Hosted in Miami, this conference brings together ... management. , As executive talent specialists in the industries central to clinical ...
(Date:1/18/2017)... ... ... Researchers from a new study are stating that if levels of the blood ... this indicates there is still remaining prostate cancer cells that are more likely to come ... always been an indicator of whether a man’s prostate cancer is growing or not,” ...
Breaking Biology Technology: