Navigation Links
Gene-environment interaction in yeast gene expression
Date:4/13/2008

The nature vs. nurture debate is familiar to most people, and modern conclusions usually predict a balance between the two. A new paper published this week in the open-access journal PLoS Biology shows that there is a similar balance between the genes we inherit—nature—and the environment—nurture—in determining thousands of traits in yeast. As we approach the age of personal genomics, in which each of us knows something about the genetic variations we carry, it is important to understand how genes and the environment interact in order to draw medically sound conclusions from the information available—e.g. whether exercise can reduce risks that are increased because of a genetic predisposition towards a certain illness.

The phenomenon of gene/environment interaction has been documented before, that the environment affects the ways it genes are expressed so that genes that are on in one condition may be downregulated or switched off in other environments. What the new research, by Leonid Kruglyak and Erin Smith, of Princeton University, adds is the ability to study thousands of gene expression patterns simultaneously, to understand the general properties of these previously poorly understood interactions.

In this research, the individuals are yeast—one from the lab and one from the vineyard, which differed genetically and the environment varied between two energy sources: glucose and ethanol. The experiment, then, is to measure how the genetic and the environmental differences interact to alter the gene expression of the yeast cells.

The expression of many genes is under the control of other genes. This paper shows that the environment often has a bigger effect on these regulated genes than on ones that are switched on and off by other, more direct mechanisms. Intriguingly, sometimes a control gene that positively affects another gene in one environment may have the opposite effect in another environment.


'/>"/>

Contact: Natalie Bouaravong
press@plos.org
415-568-3445
Public Library of Science
Source:Eurekalert

Page: 1

Related biology news :

1. Novel living system recreates predator-prey interaction
2. ESF conference probes waters mysterious interactions at molecular level
3. Workshop assesses interactions between climate, forests and land use in the Amazon Basin
4. Stowers Proteomics Center devises method for assigning probabilities to human protein interactions
5. New Argonne study may shed light on protein-drug interactions
6. Rong Li Lab reports protein interactions of MAP kinase signaling pathway
7. New technology illuminates protein interactions in living cells
8. Odd protein interaction guides development of olfactory system
9. Keck Foundation funds study of biological interactions with nanomaterials
10. Skin oil -- ozone interactions worsen air quality in airplanes
11. Hidden interactions between predators and prey: evolution causes cryptic dynamics in ecology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/14/2016)... HANOVER , Allemagne, March 14, 2016 /PRNewswire/ ... http://www.apimages.com ) - --> - ... ) - --> ... les solutions biométriques, fournit de nouveaux lecteurs d,empreintes ... lecteur LF10 de DERMALOG sera utilisé pour produire ...
(Date:3/10/2016)... , March 10, 2016   Unisys Corporation ... and Border Protection (CBP) is testing its biometric identity ... San Diego to help identify certain non-U.S. citizens ... . The test, designed to help determine the efficiency and ... began in February and will run until May 2016. ...
(Date:3/8/2016)... RALEIGH, N.C. , March 8, 2016 /PRNewswire/ ... biometric sensor technology, today announced it has secured ... led by GII Tech, a new venture fund ... LLC, with additional participation from existing investors TDF ... use the funds to continue its triple-digit growth ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... April 27, 2016 , ... The Board of Directors ... of John Tilton as Chief Commercial Officer.  Mr. Tilton joined Biohaven from Alexion ... commercial leaders responsible for the commercialization of multiple orphan drug indications. Mr. ...
(Date:4/27/2016)... ... April 27, 2016 , ... Global Stem Cells Group ... Asia-Pacific Symposium as other research and development initiatives for potential stem cell protocol management ... Global Stem Cells Group executives began meeting to establish a working agenda and foster ...
(Date:4/26/2016)... ... April 26, 2016 , ... The European Patent Office (EPO) today ... three finalists for the European Inventor Award 2016 in the category "Non-European countries." The ... at a ceremony in Lisbon on June 9th. , The human capacity to walk ...
(Date:4/26/2016)... ... April 26, 2016 , ... ... of a significant operating grant from 1Plus12 Corporation. The grant will be used ... activities as outlined on the organization's website http://www.ivsci.org , In accounting ...
Breaking Biology Technology: