Navigation Links
Gene dose affects tumor growth
Date:1/3/2008

Researchers at Johns Hopkins and Ohio State University have found that the number of copies of a particular gene can affect the severity of colon cancer in a mouse model. Publishing in the Jan. 3 issue of Nature, the research team describes how trisomy 21, or Down syndrome in humans, can repress tumor growth.

We took a new approach to a 50-year-old debate about whether people with Down syndrome develop cancer less often than other people, says Roger H. Reeves, Ph.D., professor of physiology in the McKusick-Nathans Institute of Genetic Medicine at Hopkins. Studying the genetic differences associated with Down syndrome has revealed a new way of thinking about repressing cancer growth in everyone.

The research team started with a mouse model that carries, rather than a whole extra copy of chromosome 21 as is seen in trisomy 21, or Down syndrome, a partial copy containing 108 genes. They then mated those trisomic mice to mice that carry a mutation that causes intestinal tumors, similar to those seen in colon cancer in humans. The trisomic, colon cancer mice had 44 percent fewer intestinal tumors compared to the colon cancer mice without the extra 108 genes.

The team then used another mouse model of Down syndrome, one that carries extra copies of only 33 of the genes on chromosome 21, and repeated their genetic crosses. Mice with three copies of the 33 genes developed half the number of tumors as mice with the standard two copies. Mice carrying a deletion that left them with only one copy of these 33 genes developed twice the number of tumors as usual.

Not only does having an extra copy of one or more of these genes repress tumor formation, it turns out that missing a copy enhances tumor growth-this was really surprising, says Reeves.

Taking a closer look at the 33 genes to identify a likely culprit for the dose-specific relationship with tumor growth, the researchers focused on one gene, Ets2, which previously has b
'/>"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gender, coupled with diabetes, affects vascular disease development
2. Restless legs syndrome affects nearly 2 percent of US/UK children
3. Invasion of the brain tumors
4. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
5. Bits of junk RNA aid master tumor-suppressor gene
6. Analysis of breast and colon cancer genes finds many areas of differences between tumors
7. Tumor genome analysis unveils new insights into lung cancer
8. Cell response to stress signals predicts tumors in women with common pre-breast cancer
9. Synthetic compound promotes death of lung-cancer cells, tumors
10. MIT: Remote-control nanoparticles deliver drugs directly into tumors
11. New X-ray technique targets terrorists and tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... as a consequence of chemotherapy will benefit from a ... technology that prevents hair loss. , The research is ... scalp cooling manufacturing company, Paxman Coolers, of Fenay Bridge, ... University of Huddersfield. , The research will be led ... in the pharmacology of cancer treatment, which he will ...
(Date:10/29/2014)... Beaverton, OR) New research presented at the ... in Houston, TX showed for the first time ... in women using a readily available nutritional supplement, ... by Dr. Judith A. Smith, Pharm.D., associate professor ... Sciences at The University of Texas Health Science ...
(Date:10/29/2014)... and environmental, have been blamed for increasing the ... as a family history of schizophrenia, are widely ... gondii , a parasite transmitted by soil, undercooked ... skepticism. , A new study by Gary Smith, ... University of Pennsylvania,s School of Veterinary Medicine, used ...
Breaking Biology News(10 mins):New technology on the way to aid cancer suffers who lose their hair after chemotherapy 2HPV infections in women eradicated by AHCC, Japanese mushroom extract 2Penn vet professor investigates parasite-schizophrenia connection 2Penn vet professor investigates parasite-schizophrenia connection 3
... that died 44,000 years ago in Antarctica have provided ... traditional genetic aging measurements, and suggest those approaches have ... 200 to 600 percent. In other words, a ... 100,000 years old may actually be 200,000 to 600,000 ...
... -- Agricultural soils accumulate trace metals, particularly copper ... wastes (sewage biosolids and manures) and fungicides that are ... for tolerable concentrations of these potentially plant-toxic elements in ... effects of the metals are substantially independent and not ...
... and LAS VEGAS, Nov. 9 CBS Vision, the ... Media Group company, today announced a new research partnership that will ... housed in the MGM Grand Hotel in Las Vegas. , ... one of the county,s leading agencies, will be called Communications ...
Cached Biology News:Ancient penguin DNA raises doubts about accuracy of genetic dating techniques 2Additive copper-zinc interaction affects toxic response in soybean 2CBS and OMD Partner to Provide the Agency With Access to the Network's Television City Research Facility in Las Vegas 2CBS and OMD Partner to Provide the Agency With Access to the Network's Television City Research Facility in Las Vegas 3CBS and OMD Partner to Provide the Agency With Access to the Network's Television City Research Facility in Las Vegas 4
(Date:10/30/2014)... October 29, 2014 Global polyvinyl chloride ... world economic crisis during 2008-2009, especially in North America ... and currently is keeping to a growing trend. , ... is utilized in the construction segment. In 2013, the ... profiles, tubing, sheets and rigid film. Moreover, the PVC ...
(Date:10/30/2014)... 30, 2014 James Sherley says he has ... tissue stem cell technology since his days as a principal ... in the late 1990’s. Sherley founded the ASCTC as ... holds all the intellectual property developed in Sherley’s research over ... Massachusetts Institute of Technology (MIT), and more recently as a ...
(Date:10/30/2014)... CARLSBAD, Calif. , Oct. 30, 2014 Isis ... antisense therapeutics, today announced that management will present a company ... 2014 at 8:30 a.m. ET in Boston, MA. ... will be available on the "Investors & Media" section of ... available on the Isis website within 48 hours and will ...
(Date:10/27/2014)... Ryan Carfley , Managing Partner at ... down with Bryan Hamilton, the publisher of the Triangle Business ... in the Research Triangle region of North Carolina. , Just ... the roundtable include the role of social media in ... balance and the unique role that Millennials play in the ...
Breaking Biology Technology:Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 2Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 2Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 4Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 3
... 2011 Bayer HealthCare,s affiliate MEDRAD, Inc. today ... demonstrated a 59 percent relative reduction in target ... patients with peripheral arterial disease (PAD) treated with ... compared to standard balloon angioplasty (POBA). Additionally, for ...
... SAN DIEGO, Nov. 10, 2011 Verenium Corporation (Nasdaq: ... focused on the development and commercialization of high-performance enzymes, ... financial results for the third quarter and nine months ... strong financial and operational progress in the first nine ...
... GeoVax Labs, Inc. (OTCQB/OTCBB: GOVX), an Atlanta-based biopharmaceutical ... Human Immunodeficiency Virus (HIV) infections, today announced its financial ... GeoVax reported a net loss of $375,852 ... 30, 2011, compared to $644,666 ($0.04 per share) for ...
Cached Biology Technology:Bayer HealthCare's Cotavance® Drug Eluting Balloon With Paccocath® Technology Reduced Five-Year Target Lesion Revascularization Rates by 59 Percent in PAD Patients Compared to Those Treated With Uncoated Balloon 2Bayer HealthCare's Cotavance® Drug Eluting Balloon With Paccocath® Technology Reduced Five-Year Target Lesion Revascularization Rates by 59 Percent in PAD Patients Compared to Those Treated With Uncoated Balloon 3Bayer HealthCare's Cotavance® Drug Eluting Balloon With Paccocath® Technology Reduced Five-Year Target Lesion Revascularization Rates by 59 Percent in PAD Patients Compared to Those Treated With Uncoated Balloon 4Verenium Reports Financial Results for the Third Quarter and Nine Months Ended September 30, 2011 2Verenium Reports Financial Results for the Third Quarter and Nine Months Ended September 30, 2011 3Verenium Reports Financial Results for the Third Quarter and Nine Months Ended September 30, 2011 4Verenium Reports Financial Results for the Third Quarter and Nine Months Ended September 30, 2011 5Verenium Reports Financial Results for the Third Quarter and Nine Months Ended September 30, 2011 6Verenium Reports Financial Results for the Third Quarter and Nine Months Ended September 30, 2011 7Verenium Reports Financial Results for the Third Quarter and Nine Months Ended September 30, 2011 8Verenium Reports Financial Results for the Third Quarter and Nine Months Ended September 30, 2011 9GeoVax Labs, Inc. Announces Nine Month 2011 Financial Results 2GeoVax Labs, Inc. Announces Nine Month 2011 Financial Results 3GeoVax Labs, Inc. Announces Nine Month 2011 Financial Results 4GeoVax Labs, Inc. Announces Nine Month 2011 Financial Results 5
... [RS17 ] to PRKAR2 cAMP is ... of cellular functions. cAMP exerts its effects ... which transduces the signal through phosphorylation of ... AMPK is a tetramer composed of two ...
... Rocking Shaker provides the exact agitation ... The very slow to fast speed ... provide a gentle wave motion that ... blotted membranes to achieve faster, more ...
...
... Have you bought a Perkin Elmer UltraVIEW ... using the Andor iXon and iQ software? No ... that upgrade. You keep your existing microscope, lasers, ... will customise it to work with our precision ...
Biology Products: