Navigation Links
Gene discovery reveals a critical protein's function in hearing
Date:8/21/2009

Discovery of a deafness-causing gene defect in mice has helped identify a new protein that protects sensory cells in the ear, according to a study by University of Iowa and Kansas State University researchers. The findings appear in the August 21 issue of the open-access journal PLoS Genetics.

In humans, hereditary deafness is one of the most common birth defects, yet most genes involved in hearing are unidentified. Mice are used as research models because mouse and human auditory genetics are very similar.

Using a deaf mouse model generated at The Jackson Laboratory, the team identified the deafness-causing defect in the claudin-9 gene. The mutated gene fails to produce normal claudin-9 protein, which, the UI team showed, is needed to maintain the proper distribution of potassium in the inner ear.

"Genes in the claudin family number at least 24 and produce proteins that prevent ions, including potassium, from moving between cells," said senior author Botond Banfi. "Sensory cells in the hearing organ are bathed in a high potassium solution on one side and in a low potassium solution on the other side. We found that claudin-9 is very important in keeping the amount of potassium on the two sides separate. This separation protects sensory cells from potassium intoxication."

When claudin-9 is mutated, potassium floods the wrong part of the sensory cells, killing most and leaving the remaining ones functionally defective.

In follow-up efforts, Banfi and colleagues are screening people with hearing impairment to see if some of them have a mutation in claudin-9.


'/>"/>

Contact: Tamsin Eldred
press@plos.org
44-122-346-3339
Public Library of Science
Source:Eurekalert

Page: 1

Related biology news :

1. Discovery of genetic mutation in Leigh syndrome
2. Discovery to aid in future treatments of third-world parasites
3. New discovery suggests trees evolved camouflage defense against long extinct predator
4. Down Under dinosaur burrow discovery provides climate change clues
5. GUMC discovery highlights new direction for drug discovery
6. Discovery may provide new treatments for alcohol dependence
7. New nanoparticles could revolutionize therapeutic drug discovery
8. Discovery of a water snake that startles fish in a way that makes them flee into its jaws
9. New discovery suggests mammoths survived in Britain until 14,000 years ago
10. Discovery of the cells water gate may lead to new cancer drugs
11. Aussie and Kiwi researchers make double MS genetic discovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015 Infinisource has launched its new NXG series of ... G2 sets a higher standard for collecting attendance and labor ... With plug-and-play installation, touch screen interface and seamless connection to ... time collection solution for the small to mid-size employer. ...
(Date:12/19/2014)... 18, 2014 Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ... 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - ... http://photos.prnewswire.com/prnh/20130307/600769 Following the ... fingerprint reading feature with the iPhone 5S. It is ...
(Date:12/17/2014)... FORT BELVOIR, Va. , Dec. 15, 2014 ... make it easier to detect and prevent counterfeit microcircuits ... the agency started performing an in-house microcircuit anti-counterfeit initiative ... of purchased microcircuits while increasing their reliability throughout the ...
Breaking Biology News(10 mins):Infinisource's NXG series sets new time clock standard 2iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3
... SANTA BARBARA, Calif., August 14, 2011 Newly diagnosed ... common: obesity. Exactly how diet and obesity trigger diabetes ... A new study led by Jamey D. Marth, Ph.D., ... the University of California, Santa Barbara and Sanford-Burnham Medical ...
... 6, 2011 Neurotechnology , a provider ... VeriSpeak , the company,s new voice identification technology. ... Development Kit (SDK) and as a new voice ... SDK, also announced today. VeriSpeak combines voiceprint identification ...
... Healthcare, Inc. (GNS) is collaborating with the National ... a supercomputing platform that can rapidly uncover cause-and-effect mechanisms ... pathology, and other areas. The results could help predict ... GNS will analyze NCI data from the laboratory ...
Cached Biology News:How fatty diets cause diabetes 2Neurotechnology Introduces VeriSpeak Voice Identification Technology 2Neurotechnology Introduces VeriSpeak Voice Identification Technology 3Neurotechnology Introduces VeriSpeak Voice Identification Technology 4GNS Healthcare Collaborates with NCI in New Approach to Lung Cancer; Supercomputer Analysis to Aid in Matching Targeted Drugs to Patients 2GNS Healthcare Collaborates with NCI in New Approach to Lung Cancer; Supercomputer Analysis to Aid in Matching Targeted Drugs to Patients 3
(Date:1/22/2015)... RBJ today announces the firm brokered a long-term lease totaling ... biopharmaceutical company, at Two Ledgemont Center in Lexington, ... president, and Brian Cohen , senior vice president, represented ... 95 Hayden Ave. Photo - http://photos.prnewswire.com/prnh/20150122/170765 ...
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart data solutions driven ... record-breaking year across the board for the company. , ... and our Smart Data solutions, our customers were able to ... to record growth for the company in 2014,” said Alok ...
(Date:1/22/2015)... Rootstown, OH (PRWEB) January 22, 2015 Crystal ... announced today that it has received AOAC-PTM Certifications for the ... O111, O121, and O145; collectively referred to as STEC or ... at 1 colony forming unit (cfu) per 325 g of ...
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently was ... Pre-Conference seminar on probiotics in San Diego, CA. , ... conference for health care professionals. This year’s pre-conference seminar was ... in health. Dr. Leyer spoke about the emerging topics and ...
Breaking Biology Technology:Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Cambridge Semantics Announces Record Results for 2014 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2
... June 24 CV Therapeutics,Inc. (Nasdaq: CVTX ... commercial,launch of Lexiscan(TM) by Astellas Pharma US, Inc., ... million from TPG-Axon Capital, through an,affiliated entity (TPG-Axon). ... in the second quarter of 2008., The ...
... Md., June 24 Pinnacle Biologics, a private,full-service ... entered into an agreement with Chiltern International, Inc. ... for Western Europe., James R. Miller, President ... the Chiltern agreement represents a significant step in ...
... Lawrence Livermore National Laboratory researchers have captured time-series ... the ultra-fast timescale. , Using femtosecond X-ray free ... Anton Barty, is able to observe condensed phase ... fluctuations in the liquid state or in biologically ...
Cached Biology Technology:Commercial Launch of Lexiscan(TM) (Regadenoson) Injection Triggers $10 Million Milestone Payment from TPG-Axon Capital to CV Therapeutics 2Commercial Launch of Lexiscan(TM) (Regadenoson) Injection Triggers $10 Million Milestone Payment from TPG-Axon Capital to CV Therapeutics 3Commercial Launch of Lexiscan(TM) (Regadenoson) Injection Triggers $10 Million Milestone Payment from TPG-Axon Capital to CV Therapeutics 4Pinnacle Biologics Announces Contract With Chiltern 2A look into the nanoscale 2
... The PowerPac HV high-voltage power supply, with ... increased output of 5,000 V, 500 mA, and ... monitor gel temperature between 0 and 90 degrees ... wireless data transfer. Power cord and instructions are ...
... IEF cell is an apparatus dedicated to ... or agarose slab gels. The cell includes ... casting tray, 5 glass plates, 50 sheets ... sample templates, and instructions. Dimensions are 21 ...
... Biomek FX provides complete solutions ... With 96-, 384-, and ... in either single or dual ... offers maximum speed and flexibility ...
BD Falcon, microtest ELISA plate 96 well flat-bottom, clear. Polystyrene, nonsterile, no lid (25/sp, 100/ca) Packaging: 25 / pack, 100 / case ...
Biology Products: