Navigation Links
Gene discovery reveals a critical protein's function in hearing
Date:8/21/2009

Discovery of a deafness-causing gene defect in mice has helped identify a new protein that protects sensory cells in the ear, according to a study by University of Iowa and Kansas State University researchers. The findings appear in the August 21 issue of the open-access journal PLoS Genetics.

In humans, hereditary deafness is one of the most common birth defects, yet most genes involved in hearing are unidentified. Mice are used as research models because mouse and human auditory genetics are very similar.

Using a deaf mouse model generated at The Jackson Laboratory, the team identified the deafness-causing defect in the claudin-9 gene. The mutated gene fails to produce normal claudin-9 protein, which, the UI team showed, is needed to maintain the proper distribution of potassium in the inner ear.

"Genes in the claudin family number at least 24 and produce proteins that prevent ions, including potassium, from moving between cells," said senior author Botond Banfi. "Sensory cells in the hearing organ are bathed in a high potassium solution on one side and in a low potassium solution on the other side. We found that claudin-9 is very important in keeping the amount of potassium on the two sides separate. This separation protects sensory cells from potassium intoxication."

When claudin-9 is mutated, potassium floods the wrong part of the sensory cells, killing most and leaving the remaining ones functionally defective.

In follow-up efforts, Banfi and colleagues are screening people with hearing impairment to see if some of them have a mutation in claudin-9.


'/>"/>

Contact: Tamsin Eldred
press@plos.org
44-122-346-3339
Public Library of Science
Source:Eurekalert

Page: 1

Related biology news :

1. Discovery of genetic mutation in Leigh syndrome
2. Discovery to aid in future treatments of third-world parasites
3. New discovery suggests trees evolved camouflage defense against long extinct predator
4. Down Under dinosaur burrow discovery provides climate change clues
5. GUMC discovery highlights new direction for drug discovery
6. Discovery may provide new treatments for alcohol dependence
7. New nanoparticles could revolutionize therapeutic drug discovery
8. Discovery of a water snake that startles fish in a way that makes them flee into its jaws
9. New discovery suggests mammoths survived in Britain until 14,000 years ago
10. Discovery of the cells water gate may lead to new cancer drugs
11. Aussie and Kiwi researchers make double MS genetic discovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... March 31, 2016   ... or the "Company") LegacyXChange is excited to ... its soon to be launched online site for trading ... ) will also provide potential shareholders a sense ... technology to an industry that is notorious for fraud. ...
(Date:3/29/2016)... 2016 LegacyXChange, Inc. (OTC: ... SelectaDNA/CSI Protect are pleased to announce our successful effort ... variety of writing instruments, ensuring athletes signatures against counterfeiting ... from athletes on LegacyXChange will be assured of ongoing ... Bill Bollander , CEO states, "By ...
(Date:3/22/2016)... 22, 2016 According ... Market for Consumer Industry by Type (Image, Motion, ... (Communication & IT, Entertainment, Home Appliances, & ... to 2022", published by MarketsandMarkets, the market ... reach USD 26.76 Billion by 2022, at ...
Breaking Biology News(10 mins):
(Date:5/3/2016)... , ... May 03, 2016 , ... According to world ... for definitive prostate cancer treatment, patients traditionally had two main treatment options: surgery or ... would be made. , New technology has enabled doctors to administer higher doses ...
(Date:5/2/2016)... , May 2, 2016 Q ... its technology partner Mannin Research Inc. will be attending ... which takes place from May 1-5, 2016 in ... be meeting with its vendors and research partners. The ... development goals and other collaborative opportunities for the MAN-01 ...
(Date:5/2/2016)... CA (PRWEB) , ... May 02, 2016 , ... StarNet ... solutions today announced the addition of three Secure Remote Desktop modules to its flagship ... remote desktops from Linux and Unix servers to the user’s PC over encrypted SSH. ...
(Date:4/29/2016)... Como, Italy (PRWEB) , ... April 30, 2016 , ... ... their extraordinary textile design, the bioLogic team explored how bacterial properties can be applied ... ways of using Natto bacteria, which move in response to humidity change. The team ...
Breaking Biology Technology: