Navigation Links
Gene discovery reveals a critical protein's function in hearing
Date:8/21/2009

Discovery of a deafness-causing gene defect in mice has helped identify a new protein that protects sensory cells in the ear, according to a study by University of Iowa and Kansas State University researchers. The findings appear in the August 21 issue of the open-access journal PLoS Genetics.

In humans, hereditary deafness is one of the most common birth defects, yet most genes involved in hearing are unidentified. Mice are used as research models because mouse and human auditory genetics are very similar.

Using a deaf mouse model generated at The Jackson Laboratory, the team identified the deafness-causing defect in the claudin-9 gene. The mutated gene fails to produce normal claudin-9 protein, which, the UI team showed, is needed to maintain the proper distribution of potassium in the inner ear.

"Genes in the claudin family number at least 24 and produce proteins that prevent ions, including potassium, from moving between cells," said senior author Botond Banfi. "Sensory cells in the hearing organ are bathed in a high potassium solution on one side and in a low potassium solution on the other side. We found that claudin-9 is very important in keeping the amount of potassium on the two sides separate. This separation protects sensory cells from potassium intoxication."

When claudin-9 is mutated, potassium floods the wrong part of the sensory cells, killing most and leaving the remaining ones functionally defective.

In follow-up efforts, Banfi and colleagues are screening people with hearing impairment to see if some of them have a mutation in claudin-9.


'/>"/>

Contact: Tamsin Eldred
press@plos.org
44-122-346-3339
Public Library of Science
Source:Eurekalert

Page: 1

Related biology news :

1. Discovery of genetic mutation in Leigh syndrome
2. Discovery to aid in future treatments of third-world parasites
3. New discovery suggests trees evolved camouflage defense against long extinct predator
4. Down Under dinosaur burrow discovery provides climate change clues
5. GUMC discovery highlights new direction for drug discovery
6. Discovery may provide new treatments for alcohol dependence
7. New nanoparticles could revolutionize therapeutic drug discovery
8. Discovery of a water snake that startles fish in a way that makes them flee into its jaws
9. New discovery suggests mammoths survived in Britain until 14,000 years ago
10. Discovery of the cells water gate may lead to new cancer drugs
11. Aussie and Kiwi researchers make double MS genetic discovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... PUNE, India , March 28, 2017 ... (Analog, IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), ... Maintenance), Vertical, and Region - Global Forecast to 2022", ... 30.37 Billion in 2016 and is projected to reach ... 15.4% between 2017 and 2022. The base year considered ...
(Date:3/24/2017)... , March 24, 2017 The Controller General of ... Mr. Abdulla Algeen have received the prestigious international IAIR Award ... Continue Reading ... ... and Deputy Controller Abdulla Algeen (small picture on the right) have received ...
(Date:3/23/2017)... 2017 The report "Gesture Recognition and Touchless Sensing Market ... - Global Forecast to 2022", published by MarketsandMarkets, the market is expected to ... between 2017 and 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... , Aug. 16, 2017  This year,s edition of the Inc. ... in life sciences workforce solutions, has made the list for the third ... recognizes the nation,s fastest-growing private companies based on a set of quantitative ... which includes the fastest-growing companies in the Bay State ... Inc. 5000 ...
(Date:8/15/2017)... NC (PRWEB) , ... August 15, 2017 , ... ... 2017, celebrating 10 years of successes helping medical technology companies and inventors develop and ... to a renowned full-service national engineering firm with a portfolio of clients in the ...
(Date:8/15/2017)... , ... August 15, 2017 , ... Any expert in ... has compromised these disciplines for more than half a century. Despite their essential ... It is widely known that molecular tags developed for this purpose also tag ...
(Date:8/15/2017)... (PRWEB) , ... August 15, 2017 , ... ... and is threatened by various biotic and abiotic factors. During this educational webinar, ... history of coffee, as well as gain a better understanding of how genomics ...
Breaking Biology Technology: