Navigation Links
Gene discovery made easier with powerful new networking technique
Date:1/29/2008

twork, Lee, a postdoctoral researcher in Marcottes group, synthesized data from about 20 million experiments from around the world. A visual representation of the networkwhich has the appeal of a work of modern artis a complex web of lines interconnecting the worms 16,000 genes.

In one set of studies, the researchers looked for genes that cause tumors in the worms. The tumors are a model for human eye cancer (retinoblastoma) and appear as growths along the length of the worms bodies.

By searching the network, they found about 170 new genes that could have been involved in the development of tumors.

Then Marcottes colleagues at the Wellcome Trust Sanger Institute in Cambridge in the United Kingdom tested the function of the new genes by inactivating them with a technique known as RNAi. The technique mimics the action of a potential drug by knocking out the function of individual genes.

They found that inactivating 16 of the 170 genes reversed tumors in the worms.

In similar studies, the researchers identified genes that regulate life span in the worms and manipulated the genes to extend the worms lives by 55 percent.

This sets the stage for making equivalent networks for the mouse and human genome, Marcotte says. Then we hope we can discover genes that are causal for disease conditions in humans.


'/>"/>

Contact: Edward Marcotte
marcotte@icmb.utexas.edu
512-471-5435
University of Texas at Austin
Source:Eurekalert

Page: 1 2

Related biology news :

1. Weird water: Discovery challenges long-held beliefs about waters special properties
2. UBC discovery unlocks tree genetics, gives new hope for pine beetle defense
3. Leading researchers and experts gather to discuss latest advancements in drug discovery
4. New discovery could reduce the health risk of high-fat foods
5. Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
6. Profound immune system discovery opens door to halting destruction of lupus
7. Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration
8. Yale discovery suggests protein may play a role in severe asthma
9. Researchers discovery may lead to hypertension treatment
10. Natural product discovery by Cleveland medical researchers blocks tissue destruction
11. Emory paleontologist reports discovery of carnivorous dinosaur tracks in Australia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... Wallerian degeneration is a subject of major interest ... differentially regulated during the distinct stages of Wallerian ... differentiation and dedifferentiation. Although gene expression responses in ... peripheral nerve injury are known, differences in gene ... unclear. Dr. Dengbing Yao and co-workers from Nantong ...
(Date:7/30/2014)... the roughly 3,000 pieces is still in its infant ... will be of major significance. "Amazingly often, we are ... Fushun amber that we found in Baltic amber," explained ... Baltic amber comes from the Baltic Sea region, which ... finds are, e.g., the coastal regions of Mecklenburg, Poland ...
(Date:7/29/2014)... of Bristol,s Nutrition and Behaviour Unit (NBU) has looked ... planning meals. , The research, to be presented at ... (SSIB 2014) in Seattle, USA this week [29 July ... team was led by Professor Jeff Brunstrom, and is ... part of a Biotechnology and Biological Sciences Research Council ...
Breaking Biology News(10 mins):Chinese mosquitos on the Baltic Sea 2
... continues to reduce its carbon footprint through enhanced sustainability ... efforts have been crucial to the university,s recent recognition ... Colleges." UH has been recognized as a green university ... "UH is thrilled to be recognized again by The ...
... Botanic Gardens, Kew (RBG Kew), the Royal Botanic Garden ... the Missouri Botanical Garden (MBG), have announced plans to ... the world,s plantsto be made available by the year ... information on up to 400,000 plant species worldwide. It ...
... they were the ultimate survivors. They successfully negotiated three ... end of the Cretaceous along with the dinosaurs: Ammonoids, ... cephalopods believed to be related to today,s squid and ... the course of evolution. However, what was once a ...
Cached Biology News:UH makes Princeton Review's Green List 3 years in a row 2Botanical institutions announce plans to create first online World Flora 2Botanical institutions announce plans to create first online World Flora 3First fruitful, then futile: Ammonites or the boon and bane of many offspring 2
(Date:7/30/2014)... (PRWEB) July 30, 2014 Adding to ... weighing boat special – Buy 2 of ... This promotion will benefit lab technicians looking for durable ... boats are ideal for multiple applications including weighing liquids, ... variety of choices including diamond-shaped, hexagonal, square, aluminum weighing, ...
(Date:7/29/2014)... SoundConnect , an award ... proud to announce the strategic additions of implementation, ... Boston, Charleston and Atlanta offices. SoundConnect’s organizational ... for hosted solutions, collaboration and mobility that improve ... , SoundConnect was founded in 2004, with the ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 The advanced ... the brain that are driving a revolution in the ... new peer-reviewed journal published by SPIE, the international ... issue coincides with the launch of the BRAIN Initiative ... articles that lay out a vision for and provide ...
(Date:7/29/2014)... particle be separated from its properties? On July 29, ... results of the first Cheshire Cat experiment, separating a ... in Orange, CA, and Vienna University of Technology. , ... grin," thought Alice in Wonderland, "but a grin without ... saw in my life!" Alice,s surprise stems from her ...
Breaking Biology Technology:Weighing Boat Promotion Now Available at Pipette.com, Major Pipette Distributor 2SoundConnect Organization and Culture is Evolving 2SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 2SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 3SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 4The quantum Cheshire cat: Scientists separate a particle from its properties 2The quantum Cheshire cat: Scientists separate a particle from its properties 3The quantum Cheshire cat: Scientists separate a particle from its properties 4
... Formulation and CHO cGMP Media Library for Cell Culture ... a business segment within SAFC(R), a member of the ... that it has expanded its portfolio of products and ... line applications with the introduction of EX-CELL(TM) CD ...
... 8 Advanced Life Sciences Holdings, Inc. (Nasdaq: ... novel once-a-day antibiotic, to treat respiratory tract infections and ... filed a shelf registration statement on Form S-3 with ... and when the shelf registration statement is declared effective ...
... guide designed to help consulting engineers and ... environmentsBUFFALO GROVE, Ill., April 8 Siemens ... Life Science Solutions Design Guide written expressly ... are looking to design and specify effective ...
Cached Biology Technology:SAFC Biosciences(R) Expands Media Capability for Chinese Hamster Ovary (CHO) Cell Lines 2SAFC Biosciences(R) Expands Media Capability for Chinese Hamster Ovary (CHO) Cell Lines 3SAFC Biosciences(R) Expands Media Capability for Chinese Hamster Ovary (CHO) Cell Lines 4Advanced Life Sciences Announces Filing of Shelf Registration Statement 2Advanced Life Sciences Announces Filing of Shelf Registration Statement 3Siemens Offers Life Science Solutions Design Guide for Consulting Engineers 2
Mouse monoclonal antibody raised against a full length recombinant GPT. NCBI Entrez Gene ID = GPT...
Mouse monoclonal antibody raised against a partial recombinant TPR. NCBI Entrez Gene ID = TPR...
... Each kit contains sufficient materials for 1,464 array sample ... Membrane: 4 each , Blocker BSA in PBS (10X): ... BupH Phosphate Buffered Saline: 8 packs , 10% Tween-20: ... Luminol Enhancer: 2 x 25 ml , SuperSignal West ...
... 100-120 V, is used for biolistic particle ... device employs an adjustable helium pulse to ... microcarriers from the inner wall of a ... This system has a 2 square-centimeter target ...
Biology Products: