Navigation Links
Gene discovery made easier with powerful new networking technique
Date:1/29/2008

AUSTIN, TexasThe identification of disease-causing genes will be much easier and faster using a powerful new gene-networking model developed by researchers at The University of Texas at Austin.

Edward Marcotte and his colleague, postdoctoral researcher Insuk Lee, used the gene network technique to identify new genes that regulate life span and are involved in tumor development in the nematode worm.

In collaboration with Andrew Frasers group at The Wellcome Trust Sanger Institute, the researchers manipulated the newly found genes and were able to extend the lives of the worms by 55 percent and reverse the onset of tumors.

Marcotte hopes to extend the technique to identifying genes for disease and other disorders in humans. The human genome has been sequenced, but very little is known about what more than half of about 20,000 genes do.

This is a big step forward in the rational discovery of disease genes, says Marcotte, a professor in the Institute for Cellular and Molecular Biology. We can use this gene modeling technique to predict the function of new genes and then run experiments to confirm the findings.

The process could greatly improve our ability to pinpoint specific genes involved in disease and aid in the development of drugs.

Marcottes research was published January 27 online in Nature Genetics.

Gene networks are models of the connections between all of the genes within an organism, and Marcotte uses them like an online social network. He learns what new genes do by the genes connections to others in the network, much like people use online social networking systems to connect with friends and others with similar interests.

You can think of it like six degrees of separation or a Facebook.com for genes, says Marcotte. If you know of a few genes and what they do, their friends probably do something similar, and we can find these through the network.

To build the worm gene ne
'/>"/>

Contact: Edward Marcotte
marcotte@icmb.utexas.edu
512-471-5435
University of Texas at Austin
Source:Eurekalert

Page: 1 2

Related biology news :

1. Weird water: Discovery challenges long-held beliefs about waters special properties
2. UBC discovery unlocks tree genetics, gives new hope for pine beetle defense
3. Leading researchers and experts gather to discuss latest advancements in drug discovery
4. New discovery could reduce the health risk of high-fat foods
5. Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
6. Profound immune system discovery opens door to halting destruction of lupus
7. Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration
8. Yale discovery suggests protein may play a role in severe asthma
9. Researchers discovery may lead to hypertension treatment
10. Natural product discovery by Cleveland medical researchers blocks tissue destruction
11. Emory paleontologist reports discovery of carnivorous dinosaur tracks in Australia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... To date, antidotes ... doctors are often limited to supportive therapy such as induced ... of drugs involved. So what can be done if a ... professor Jean-Christophe Leroux from the Institute of Pharmaceutical Sciences at ... "The task was to develop an agent that could eliminate ...
(Date:10/16/2014)... Mary,s Virginia Institute of Marine Science have received ... Agency to identify the streams and wetlands most ... to help local governments and citizens conserve these ... a dataset of tidal-marsh observations first gathered by ... historical baseline can today,s researchers accurately map the ...
(Date:10/16/2014)... challenged conventional thinking on how the bowel lining develops ... how bowel cancer starts. , The researchers produced evidence ... the ,crypts, that are a feature of the bowel ... bowel cancer development, a controversial finding as scientists are ... 3D imaging technologies, Dr Chin Wee Tan and Professor ...
Breaking Biology News(10 mins):Emergency aid for overdoses 2Emergency aid for overdoses 3EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3Cryptic clues drive new theory of bowel cancer development 2
... experiences trauma or disease, such as muscular dystrophy, ... cells" respond to repair and regenerate the muscle. ... such as muscular dystrophy, which affect muscle stability ... used time-lapse photography to document satellite cell movements ...
... PHILADELPHIA Although acute myeloid leukemia (AML) is relatively ... the risk, according to a recent paper published in ... of the American Association for Cancer Research. Julie ... and clinical research at the University of Minnesota, said ...
... to the poles, and you,ll notice that the ... equator. Move from lowland to mountains, and you,ll ... varied. Ecologists have proposed various explanations for these ... processes. New findings by University of ...
Cached Biology News:Caught on tape: Muscle stem cells captured on video by MU researcher 2Climate change and mountain building led to mammal diversity patterns 2
(Date:10/25/2014)... Investor-Edge has initiated coverage on the following ... Pharmaceuticals Inc. (NASDAQ: VRTX ), Alexion Pharmaceuticals ... (NASDAQ: PPHM ), and StemCells Inc. (NASDAQ: ... accessed at: http://investor-edge.com/register . The US ... positive note as the Dow Jones Industrial Average finished ...
(Date:10/22/2014)... DUBLIN , Oct. 22, 2014 ... addition of the "Global DNA Diagnostics Market ... - Size, Share, Global Trends, Company Profiles, Demand, ... 2013 - 2020" report to their offering. ... diagnostics Market (products, applications, techniques, end users and ...
(Date:10/22/2014)... 2014 Shimadzu Scientific Instruments introduces its ... for the pain management and clinical markets. The software ... review by allowing users to highlight and review results ... QuantAnalytics allows analysts to filter results by group or ... by eliminating the need to sift through analytes of ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 Grace Century, ... and healthcare projects, announces the addition of Dr. ... to its advisory team. Dr. Siddiqui will provide further ... , A graduate of University College Medical School ... degreed in medicine in 2001. With further certification as ...
Breaking Biology Technology:Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 2Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 3Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 4Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 5Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 2Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 3Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2Dr. Yousef Siddiqui joins the Grace Century Advisory Team 2
... in a hexagonal, chicken wire structure holds great ... conductive, graphene may one day replace conventional silicon microchips, ... In addition to potential applications in integrated circuits, solar ... material has attracted the attention of physicists for its ...
... Inc. (NYSE Amex: NBS ), an international biopharmaceutical company ... will present on a panel at the 31st Annual Cowen Group ... March 7, 2011 at 1 PM and Dr. Robin Smith, the ... at 10:15 AM. The Conference will be held at the Boston ...
... Corporation (Nasdaq: VOLC ), a leading developer ... enhance the diagnosis and treatment of coronary and peripheral ... market the Eagle Eye® Platinum digital IVUS catheter in ... PCI Live Demonstration Course in Kurashiki, which starts on ...
Cached Biology Technology:Probing atomic chicken wire 2Probing atomic chicken wire 3Probing atomic chicken wire 4NeoStem to Present at Cowen Group 31st Annual Health Care Conference on March 7 and 8 2NeoStem to Present at Cowen Group 31st Annual Health Care Conference on March 7 and 8 3Volcano Announces the Introduction of the Eagle Eye® Platinum Digital IVUS Catheter at the 20th PCI Live Demonstration Course in Kurashiki 2Volcano Announces the Introduction of the Eagle Eye® Platinum Digital IVUS Catheter at the 20th PCI Live Demonstration Course in Kurashiki 3
Recommended for supporting the growth of anchorage-dependent cells including human and mouse stromal cells, mesenchymal cells and cell lines....
... number is a new product ... Cornings product number. If showing ... under the old Sigma-Aldrich number ... for assistance. ID clarifier: cap, ...
Extremely high efficiency packaging extracts useful for transfecting our EpiFOS™ or CopyControl™ Fosmids, or any DNA vector with cos sites. A tremendous value when conpared to the competition...
... General description: Workstation for PCR set-up ... 96 MicroWell format to hold 0.2 ml PCR tubes, ... compatible with automated handling systems Removable tray ... Compatible with V-bottom 0.2 ml tube block thermal ...
Biology Products: