Navigation Links
Gene discovery could lead to male contraceptive
Date:4/2/2009

ed in male infertility in mice, the researchers found that mutations in both Iranian families occurred in a single gene called CATSPER1. DNA analysis revealed two different mutations -- one in each family -- but both mutations would likely lead to either a very truncated, non-functional version of the protein, or no protein at all. Neither mutation was found in the DNA of 576 Iranian individuals who were screened as controls.

Harvard University studies on mouse models that lack the CATSPER1 gene reveal how sperm is affected when the protein is missing or abnormal. These studies show that CATSPER1 mutations affect sperm motility, specifically the very vigorous hyperactive motion the sperm uses when it is entering the egg during fertilization.

"Our research suggests that the defect in sperm hyperactivity that is seen in mice without CATSPER1 will also occur in humans with the genetic mutation," Hildebrand said. "Identification of targets such as the CATSPER1 gene that are involved in the fertility process and are specific for sperm -- potentially minimizing side effects of a drug targeting the protein's function -- provide new targets for a pharmacological male contraceptive."

Several approaches to male contraception are currently under investigation at other institutions. One approach that could potentially target CATSPER1 is immunocontraception where antibodies are developed that bind to a targeted protein and block its function. Immunocontraception is still in early stages of development and in order to be useful it will need to be proven effective, safe and reversible.


'/>"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-335-9917
University of Iowa
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Bioscience institutions come together to launch Microlife Discovery Center for area students
2. Teeth of Columbus crew flesh out tale of new world discovery
3. Elephant shark genome sequence leads to discovery of color perception in deep-sea fish
4. Cellular discovery may lead to targeted treatment for rare form of anemia
5. New discovery paves the way for new diagnosis of serious lung disease
6. La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery
7. Rett Syndrome Research Trust advisor makes significant discovery
8. Singapore research organisations team up to advance drug discovery using brain tumor stem cells
9. Breaking the barrier: Discovery of anti-resistance factors and novel ocean drugs
10. Major step for drug discovery and diagnostics
11. Cell-building discovery could reduce need for some animal research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene discovery could lead to male contraceptive
(Date:8/29/2014)... 29, 2014) Scientists at the Barshop Institute for ... Medicine at the UT Health Science Center at San ... tissues of the longest-lived rodent, the naked mole rat. ... cells of naked mole rats protects and alters the ... and obsolete proteins. , The factor also protects proteasome ...
(Date:8/29/2014)... release is available in German . ... players in the natural nitrogen cycle on Earth and ... bacteria were thought to depend on nitrite as their ... by Holger Daims, a microbiologist at the University of ... hydrogen as an alternative source of energy. The oxidation ...
(Date:8/29/2014)... Boulder, Colo., USA - The rise of the Tibetan ... on Earth -- is important for both its profound ... In this study published in GSA Bulletin , ... -- "clumped" isotope thermometry -- using modern and fossil ... Zhada basin in southwestern Tibet. , Views range ...
Breaking Biology News(10 mins):Factor in naked mole rat's cells enhances protein integrity 2Hydrogen powers important nitrogen-transforming bacteria 2Hydrogen powers important nitrogen-transforming bacteria 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7
... (UH) executed two license agreements with SuperPower, a ... covers the intellectual property on second generation (2G) ... under the Sponsored Research Agreement (SRA) previously executed ... is led by Venkat Selvamanickam, M.D. Anderson chair ...
... the Ministry of Public Health and Sanitation, together with ... Adolescent Health), unveiled a renewed set of national policy ... by putting proven interventions to work within the country,s ... global progress against diarrhoea has stalled. Contrary to what ...
... with legends of European monarchs, frail heirs and one flamboyant ... the very treatments that can help can also put patients, ... an expensively produced protein that helps the blood to clot. ... and in a subset of those, it sets off an ...
Cached Biology News:SuperPower and UH sign high temperature superconducting wire license agreements 2Policy unveiled to combat diarrheal disease, a killer of Kenyan children 2Policy unveiled to combat diarrheal disease, a killer of Kenyan children 3Researchers harness the power of plants to fight hemophilia 2Researchers harness the power of plants to fight hemophilia 3Researchers harness the power of plants to fight hemophilia 4
(Date:8/29/2014)... Due to a misstatement posted by the ... Stem Cell Technology Center, LLC ( ASCTC ) was reported ... research that might benefit ALS patients. Because of ASCTC's ... cell technologies and therapeutic applications, FRC listed ASCTC as one ... donors who wish not to support research that requires the ...
(Date:8/29/2014)... August 29, 2014 Intrinsic Imaging, ... certified, GAMP® 5 compliant imaging core lab, announced ... Phase II clinical trial to assess a new ... this trial, Intrinsic Imaging will provide comprehensive imaging ... protocol and charter development, site qualification, site training ...
(Date:8/28/2014)... Nevada City, CA (PRWEB) August 28, 2014 ... and sanitation products for the food processing industry, is ... conducting a side-by side comparison of the E2 soap ... Q E2 Sanitizing Foam Soap . Hand hygiene ... pathogens in the food processing environment. Six key criteria ...
(Date:8/28/2014)... Lawrence, MA (PRWEB) August 28, 2014 “This ... single test to screen from 0 to 150 ppb,” said ... test is a significant benefit to plant owners and USDA-GIPSA ... corn and other commodities. Testing can take place in a ... Not only can the plant test the feed and grain ...
Breaking Biology Technology:The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 3Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2
...  A recent Van Andel Research Institute (VARI) study published in ... function of an essential plant hormone could profoundly change our ... to the development of new drugs for a variety of ... by the same team of investigators at VARI that was ...
... 2012  PinneyAssociates, Inc., a health care consulting firm with offices ... the following promotions, effective 1 January 2012: , ... , Lucy Owen, to Vice President, Program Operations and ... President , Joe Gitchell, to President , John ...
... Aethlon Medical, Inc. (OTCBB: AEMD), the ... address infectious disease, cancer and other life-threatening conditions, ... Therapy Scientific Advisory Board to guide the advancement ... from the Aethlon ADAPT™ system.  Aethlon recently established ...
Cached Biology Technology:Van Andel Research Institute Study Provides New Details of Fundamental Cellular Process 2PinneyAssociates Announces Senior Staff Promotions 2Aethlon Medical Establishes Extracorporeal Therapy Scientific Advisory Board 2Aethlon Medical Establishes Extracorporeal Therapy Scientific Advisory Board 3Aethlon Medical Establishes Extracorporeal Therapy Scientific Advisory Board 4Aethlon Medical Establishes Extracorporeal Therapy Scientific Advisory Board 5Aethlon Medical Establishes Extracorporeal Therapy Scientific Advisory Board 6Aethlon Medical Establishes Extracorporeal Therapy Scientific Advisory Board 7
... HERAfreeze ultra low temperature freezers offer ... safe storage of biological samples with ... five separate inner doors ensure excellent ... costs. ,Application oriented accessories simplify ...
...
...
Physical Form: powder Color: white Removes FLAG peptide from N-terminal and Met-N-terminal fusion proteins. Supplied with optimized enterokinase buffer....
Biology Products: