Navigation Links
Gene defect that predisposes people to leukemia discovered
Date:9/4/2011

n GATA 2 cause such assorted health problems. Also perplexing is how hard it has been to find genetic errors underlying blood cancers, compared with other cancers.

"While several genes have been discovered and linked to solid, malignant tumors such as breast cancer in families susceptible to those types of cancer, so far very few inherited mutations have been uncovered for blood cancers," Horwitz said.

Previously, other scientists linked mutations in two other genes -- RUNX1 and CEBPA to injerited forms of myelodysplastic syndrome and acute myeloid leukemia. These genes bind to DNA and control the copying of information encoded in this molecule.

Keeping this in mind, researchers looked for mutations in similar genes in families who did not have the RUNX1 and CEBPA mutations and who had no other explanations for their inherited blood cancer. In so doing, the researchers identified the GATA2 mutations. They also observed that these mutations relate to loss of function by making the gene unable to perform the molecular duties necessary to manufacture healthy white blood cells.

According to Horwitz, the GATA2 mutations in DNA occur adjacent to an amino acid mutated in some patients with terminal chronic myeloid leukemia. This proximity suggests a common pathway may be critical for several types of myeloid malignancies, he said.

People at risk because of their pedigree eventually may obtain tests to detect this genetic error before symptoms emerge. Learning that they have the gene mutation might help patients and their doctors decide on appropriate follow-up for early diagnosis and treatment of problems that might arise.

Additional knowledge about how the GATA2 gene and its mutations operate may foster the development of new therapeutic agents.


'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Sight fails when defective eye cells cripple renewal
2. Study suggests new strategy to prevent infertility, birth defects
3. Vanishing twin explains increased risk of birth defects
4. Large numbers of birth defects seen near mountaintop mining operations
5. Researchers discover precisely how thalidomide causes birth defects
6. Compound useful for studying birth defects may also have anti-tumor properties
7. Common congenital defect a prickly problem for the kidney
8. Study shows rapamycin reverses myocardial defects in mouse model of LEOPARD syndrome
9. Defective cell surface glue is key to tumor invasion
10. Scientists find gene linked to congenital heart defect
11. Children with autism more likely to have mitochondrial defects impacting cellular energy production
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene defect that predisposes people to leukemia discovered
(Date:3/24/2015)... ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the addition of the ... report to their offering. This report analyzes the worldwide ... following Segments: Face Biometrics, and Voice Biometrics. The report provides separate ... Japan , Europe , ... Africa , and Latin America . ...
(Date:3/23/2015)... YORK , March 23, 2015   HOYOS ... property management company, today announced that the Company will ... for both enterprise and consumers at Connect:ID on March ... HOYOS Labs will highlight the IEEE Biometric ... TM ; and enterprise access control system. BOPS ...
(Date:3/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ) has announced ... Business Report" report to their offering. This ... Thousands. The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... Annual estimates and forecasts are provided for the ...
Breaking Biology News(10 mins):Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4
... presented Jim Gartland of the Virginia Institute of Marine ... for his outstanding contributions to the field of fisheries ... Atlantic coastal states in 1942 for the conservation and ... covers near-shore waters from Florida to Maine. ASMFC ...
... NYNovember 6, 2013: Decades worth of research shows that teathe ... illnesses, including heart disease, certain types of cancer and type ... help promote weight loss and maintain a healthy weight, improve ... attention, problem solving and mood. The December 2013 issue ...
... suggests that the brain plays a key role in glucose regulation ... Nov. 7 issue of the journal Nature . If the ... ways to prevent and treat this disease, which is projected to ... In the paper, lead author Dr. Michael W. Schwartz, director ...
Cached Biology News:ASMFC honors Gartland with Annual Award of Excellence 2ASMFC honors Gartland with Annual Award of Excellence 3New research shows tea may help promote weight loss, improve heart health and slow progression of prostate cancer 2New research shows tea may help promote weight loss, improve heart health and slow progression of prostate cancer 3New research shows tea may help promote weight loss, improve heart health and slow progression of prostate cancer 4New research shows tea may help promote weight loss, improve heart health and slow progression of prostate cancer 5Brain may play key role in blood sugar metabolism and development of diabetes 2
(Date:4/27/2015)... Diasome Pharmaceuticals, Inc. (“Diasome”) has ... Diabetes Center (“Joslin”) to collaborate on the design ... Hepatocyte Directed Vesicle (“HDV”) targeting system for insulin ... Located in Boston, Massachusetts, Joslin is the world's ... dedicated to the prevention, treatment and cure of ...
(Date:4/27/2015)... Elsevier , a world-leading provider of scientific, technical ... Office   have announced the winners of the Qatar University ... last week at Qatar University, ... guests representing Qatar,s top scientific community. ... Al-Misnad , President of Qatar University. ...
(Date:4/24/2015)... Diego, CA (PRWEB) April 24, 2015 ... Diego and other San Diego area universities, including UCSD ... 28 to judges from prominent local, national and nonprofit ... funding in the 5th Annual Social Innovation Challenge ... have proposed unique social venture ideas addressing a diverse ...
(Date:4/24/2015)... San Diego, California (PRWEB) April 24, 2015 ... Inc., announced key milestones in its allogeneic stem-cell ... VetStem Biopharma to properly reflect the corporate strategic ... that our allogeneic (donor) adipose stem cell development ... the completion of our cGMP manufacturing facility and ...
Breaking Biology Technology:Diasome Pharmaceuticals Announces Clinical Trial Design Collaboration 2Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 2Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 3Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 4Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 55th Annual Social Innovation Challenge at University of San Diego - Students Pitch to Live Judging Panel to Take Home $75K 25th Annual Social Innovation Challenge at University of San Diego - Students Pitch to Live Judging Panel to Take Home $75K 3Vet-Stem, Inc. Meets New Milestones and Changes Name to VetStem Biopharma 2
... and Funding Barriers and Paves Way ... for Affordable and Efficient Approach, KAKAMEGA, Kenya, ... and HIV was launched today in the Western,Kenyan district of ... a basic care package consisting of a,PermaNet(R) long-lasting insecticide-treated bed ...
... Institutional Investors to Attend Conference, MONTREAL, Sept. ... today announced that Mr. Pierre Laurin, President,and Chief ... 5th,annual Investor Summit on September 16, 2008 at ... Mark Hopkins InterContinental Hotel in San Francisco., ...
... Calif., Sept. 12 Acologix, Inc., a privately,held ... studies demonstrating that AC-100, its therapeutic product,candidate derived ... and,dental cells, promotes cartilage regeneration in large animal ... A. Middleton-Hardie on September,13, 2008 at the 30th ...
Cached Biology Technology:Integrated Prevention Demonstration Campaign Launched in Western Kenya to Fight HIV, Malaria and Diarrhoeal Disease 2Integrated Prevention Demonstration Campaign Launched in Western Kenya to Fight HIV, Malaria and Diarrhoeal Disease 3ProMetic to present at Merriman Curhan Ford's Investor Summit 2008 on September 16th 2Acologix Presents Preclinical Data on Cartilage Regeneration by AC-100 at the 30th ASBMR Annual Meeting 2Acologix Presents Preclinical Data on Cartilage Regeneration by AC-100 at the 30th ASBMR Annual Meeting 3
One-step, microplate or cuvet, colorimetric, detection range 0.1 mg/dL to 3 mg/dL. Procedure: 10 min....
Request Info...
Recombinant Mouse Wnt-3a...
... at least 20 structurally and functionally related ... superfamily. BMPs were originally identified as protein ... are also involved in embryogenesis and morphogenesis ... the growth, differentiation, chemotaxis and apoptosis of ...
Biology Products: