Navigation Links
Gene defect that predisposes people to leukemia discovered
Date:9/4/2011

those with the syndrome soon develop acute myeloid leukemia, in which abnormal white cells build up in the bone marrow and interfere with normal blood production.

Horwitz's Australian colleagues had described a family with a similarly inherited blood disorder. Eighteen years later, after rifling through many candidate genes, the researchers on both continents were relieved finally to have hit upon the mutated gene responsible for the leukemia that affect these families. They have gone on to identify abnormal GATA2 genes in more than 20 families and individuals.

"It's likely that this inherited error is more common than we had thought," the researchers noted. In some families with a GATA2 mutation, the over-riding concern has been leukemia, while others suffer dangerous infections from bacteria, viruses and fungi because of a lack of white blood cells to fight off germs.

The lab of Dr. Dennis Hickstein, formerly of the UW School of Medicine and the Puget Sound Veterans Affairs Health System and now at the National Institute of Health, in collaboration with NIH colleague Dr. Steven Holland, associated the mutation with mycobacteria infections. Those results were reported in separate study appearing in the journal Blood.

Another paper appearing Sept. 4 in Nature Genetics from a London group found similar mutations of GATA2 in leukemia patients with lymphedema and, in some cases, deafnesss. By blocking the vessels that drain fluid from the body's tissues, lympedema causes swelling of the arms or legs.

Ongoing work in Seattle and Adelaide has identified a congenital syndrome associated with developmental delay and a risk of myelodysplasia. This syndrome results from chromosomal loss of GATA2 and adjacent genes.

Comparable GATA2 mutations also have been found in people with the more common, non-inherited leukemias.

Scientists are trying to figure out why apparently similar gene mutations i
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Sight fails when defective eye cells cripple renewal
2. Study suggests new strategy to prevent infertility, birth defects
3. Vanishing twin explains increased risk of birth defects
4. Large numbers of birth defects seen near mountaintop mining operations
5. Researchers discover precisely how thalidomide causes birth defects
6. Compound useful for studying birth defects may also have anti-tumor properties
7. Common congenital defect a prickly problem for the kidney
8. Study shows rapamycin reverses myocardial defects in mouse model of LEOPARD syndrome
9. Defective cell surface glue is key to tumor invasion
10. Scientists find gene linked to congenital heart defect
11. Children with autism more likely to have mitochondrial defects impacting cellular energy production
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene defect that predisposes people to leukemia discovered
(Date:4/6/2015)... OXFORD, Conn. , Apr. 6, 2015 /PRNewswire/ ... the "Company"), a biometric authentication company focused on ... it has filed provisional patent 62/143028 for ... CLOSE-PROXIMITY COMMUNICATIONS AND ENERGY TRANSFER  NXT-ID introduces ... wireless payments. This patent surrounds the use of ...
(Date:4/2/2015)... At its 2015 ACMG Annual Clinical Genetics ... the American College of Medical Genetics and Genomics (ACMG) ... Board.  Members of the ACMG Board of Directors serve ... advancing its policies and programs. ACMG is the national ... an eventful time in medical genetics and genomics.  We ...
(Date:4/2/2015)... 2015 Fingerprint Cards (FPC) has ... from the distributor World Peace Industrial Group (WPI), part ... although the major part of the shipments will take ... by smartphone manufacturers in China . ... the communicated revenue guidance of + 1 000 MSEK for ...
Breaking Biology News(10 mins):NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2
... promise for significantly reducing vascular aging by inactivating TNFa, ... cell death. The related report by Csiszar et ... in the January issue of The American Journal of ... heart attack and stroke, occur naturally, even in otherwise ...
... Investigators at St. Jude Children's Research Hospital have discovered ... bacteria can cause fatal heart damage; researchers have also ... by increasing the number of cell wall pieces shed ... mouse model how to prevent this from happening. , ...
... Todd Lane and Victoria VanderNoot have been awarded ... can successfully detect deadly toxins from harmful algal ... Cooperative Institute for Coastal and Estuarine Environmental Technology ... Atmospheric Administration (NOAA) and the University of New ...
Cached Biology News:A new jump start for aging blood vessels 2Cell wall of pneumonia bacteria can cause brain and heart damage 2Cell wall of pneumonia bacteria can cause brain and heart damage 3Sandia research to focus on early detection of harmful algal blooms 2Sandia research to focus on early detection of harmful algal blooms 3
(Date:4/16/2015)... 16, 2015 Cambridge Semantics ... driven by Semantic Web technology, and Informa ... and services for the academic and scientific, professional ... joint solution ‘Smart Data Lake for Clinical Trial ... the 2015 Bio-IT ‘Best of Show’ Award. ...
(Date:4/16/2015)... (PRWEB) April 16, 2015 Capillus, ... distribution and physician network in Europe and Asia. ... has appointed Fernando Bermúdez, former Business Development Director ... An industry veteran, Mr. Bermúdez’s professional achievements include ... in Spain, while also penetrating the Portuguese marketplace ...
(Date:4/16/2015)... 16, 2015  Schulman Associates IRB, Inc., the industry-leading ... a long-term lease on Laboratory Drive in the heart ... . The location will house review board and service ... quality reviews and customer service to clients. ... Schulman in the deal, while Capital Associates Management, LLC ...
(Date:4/16/2015)... According to the 2014 Liberty Mutual ... was ranked first among the leading causes of ... pushing, pulling, holding, carrying, or throwing and cost ... Round Company takes statistics like this very seriously. ... develop and design equipment that prevents these injuries ...
Breaking Biology Technology:Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 3Capillus, LLC Extends Laser Hair Therapy Products to Europe and Asia 2Schulman IRB to Open Office in Research Triangle Park, N.C. 2The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2
, , , , back to top...
... Ltd., The Lord Zuckerman,Research Centre, Whiteknights, PO Box 234, Reading RG6 6LA, UK , ... Introduction , One of ... modified organisms (GMOs) in agriculture and food ... Europe, for clear labeling of products , ...
... Keith Hamby, and Larissa Tan, Bio-Rad Laboratories, , ... , , ... for real-time monitoring , of the polymerase chain reaction ... assay (PE Biosystems), which capitalizes on the 5' exonuclease , ...
Cached Biology Technology:The iCycler iQ and Amplifluor Detection Systems for Analysis of Genetically Modified Organisms in Foodstuffs, Rev A 2The iCycler iQ and Amplifluor Detection Systems for Analysis of Genetically Modified Organisms in Foodstuffs, Rev A 3The iCycler iQ and Amplifluor Detection Systems for Analysis of Genetically Modified Organisms in Foodstuffs, Rev A 4The iCycler iQ and Amplifluor Detection Systems for Analysis of Genetically Modified Organisms in Foodstuffs, Rev A 5The iCycler iQ and Amplifluor Detection Systems for Analysis of Genetically Modified Organisms in Foodstuffs, Rev A 6The iCycler iQ Detection System for TaqMan Assays, Rev B 2The iCycler iQ Detection System for TaqMan Assays, Rev B 3The iCycler iQ Detection System for TaqMan Assays, Rev B 4The iCycler iQ Detection System for TaqMan Assays, Rev B 5The iCycler iQ Detection System for TaqMan Assays, Rev B 6
... Convenient platform for tube handling and reagent dispensing ... tubes - 96 x 0.3ml U-bottom ... - Thermo-Fast® 96 Non-Skirted Plate - ... x 0.5ml Thermo-Tubes Multiple workstations can be securely stacked ...
... well Magnetic-Ring Stand is designed for paramagnetic ... microplates. The stand has a plastic base ... plate footprint. The use of 96 extremely ... easy magnetic separation. With this magnetic stand, ...
... • Enzyme concentration - 5 units/µL ,• ... higher yields ,• Leaves an 'A' overhang ... polymerase which exhibits very high activity in ... To ensure the quality of the enzyme, ...
Taq DNA Polymerase (T. aquaticus), 250 units. For PCR and other procedures requiring DNA polymerase activity at elevated temperatures. Category: Nucleotides & Enzymes & Biochemicals, Modifying Enzyme...
Biology Products: