Navigation Links
Gene chips used to distinguish ventilator-associated pneumonia from underlying critical illness
Date:2/12/2008

St. Louis, Feb. 13, 2008 Critically ill patients who need a ventilator to breathe face a high risk of pneumonia. The lung infection, however, is exceedingly difficult to diagnose because a patient's underlying condition often skews laboratory test results and masks pneumonia's symptoms a reality that can delay appropriate antibiotic treatment.

Using gene chip technology, scientists at Washington University School of Medicine in St. Louis demonstrate for the first time they can distinguish pneumonia associated with ventilator use from other serious illnesses. The research, published Feb. 13 in the journal Public Library of Science One, suggests that the method may lead to early, more accurate detection and treatment of ventilator-associated pneumonia.

The team analyzed patterns of expression in more than 8,000 genes as patients on mechanical ventilators developed and recovered from pneumonia. They found changes in the activity of 85 genes could pinpoint early activation of the immune system in response to pneumonia, typically several days before clinical signs of the infection developed. By adding computational tools to their genomic analysis, the researchers also showed they could objectively monitor patients' recovery by graphing changes over time, creating a tool they called the "riboleukogram."

"This is an important step toward the development of a specific molecular test for diagnosing infection in particular pneumonia and predicting patients' recovery," says J. Perren Cobb, M.D., director of Washington University's Center for Critical Illness and Health Engineering and an intensivist at Barnes-Jewish Hospital. "If we could determine which patients are destined to develop pneumonia based on early changes in the activity of genes that regulate immune response, we could give them antibiotics sooner, with the hope that we might be able to prevent or curtail the infection."

As one of the more common and deadly hospital-a
'/>"/>

Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University in St. Louis
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Princeton engineers develop low-cost recipe for patterning microchips
2. Zinc may reduce pneumonia risk in nursing home elderly
3. New thoracic imaging approach can pinpoint underlying venous problems
4. IEEE-USA commends president for asking Congress to double support for critical research
5. Diet and lifestyle critical to recovery, says study
6. Critically endangered porpoise is focus of new research report
7. Rutgers scientists research reveals critical knowledge about the nervous system
8. First-ever study: lack of critical lubricant causes wear in joints
9. Critically endangered Amur leopard captured
10. Research pioneer in the developmental origins of psychiatric illness is awarded the Sackler prize
11. Fresh-cut produce washing practices can minimize food-borne illness risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... July 10, 2014---A team of researchers from The Chinese ... identified a gene of wild soybean linked to salt ... grow in saline soil. This study published online in ... unveil novel genomic information for crop improvement. , Soybean ... domestication and human selection, cultivated soybeans have less genetic ...
(Date:7/11/2014)... July 11, 2014 Researchers have pioneered ... images. The new technology, called Virtual Finger, allows ... structures like neurons and synapses using the flat ... technology makes 3D imaging studies orders of magnitude ... an unprecedented level across many areas of experimental ...
(Date:7/11/2014)... receptor type 1 can inhibit voltage-gated calcium ... neurotransmitter release. However, some scholars demonstrated that ... Ca2+ influx and increase neurotransmitter release. Dr. ... Affiliated to Tongji Medical College, Huazhong University ... cell voltage-clamp and calcium imaging in cultured ...
Breaking Biology News(10 mins):BGI reports a novel gene for salt tolerance found in wild soybean 2Virtual finger enables scientists to navigate and analyze complex 3D images 2
... MURCIA, SPAINSalt can have drastic effects on the ... that salinity renders an about one-third of the world,s ... salinity can cause ion toxicity, osmotic stress, mineral deficiencies, ... stress can even cause plants to adjust their water ...
... of modern humans like more than 50,000 years ago? ... Stone Age engravings are the subjects of a good deal ... journal Science , an international team of researchers report ... could place the use of herbal medicines much earlier than ...
... growing in popularity as more growers turn to strip-till. However, ... worth. A new University of Illinois study revealed ... soybean. However, the results showed no difference in yield between ... corn, not soybean," said Fabian Fernandez, U of I assistant ...
Cached Biology News:Salt-tolerant crops show higher capacity for carbon fixation 2Earliest known bug-repellant plant bedding found at South African rock shelter 2Earliest known bug-repellant plant bedding found at South African rock shelter 3Earliest known bug-repellant plant bedding found at South African rock shelter 4Strip-till improves nutrient uptake and yield 2
(Date:7/10/2014)... Poway, CA (PRWEB) July 10, 2014 Robert ... Regenerative Veterinary Medicine company, is proud to announce the relaunch ... Pets, launching with a new series called “ What are ... to give an honest and straightforward foundation in the basics ... an educated decision on the right type of treatment when ...
(Date:7/10/2014)... CROWN POINT, Ind. , July 10, ... recently expanded its use of capnography for ... a growing group of healthcare leaders in ... Capnography measures how effectively patients are breathing ... respiratory depression occurs. By measuring the amount ...
(Date:7/10/2014)... Research and Markets ( http://www.researchandmarkets.com/research/s3bqj2/photonic ) ... Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module ... to their offering. ... integration traces its roots in the latter half ... integration went unexplored and unfulfilled for several decades ...
(Date:7/10/2014)... Using microscopic polymer light resonators that expand in ... Quantum Photonics Laboratory have developed new optical sensors ... Optical sensors are ideal for detecting trace gas ... lightweight nature, and immunity to electromagnetic interference. , ... before, the MIT team conceived an extremely sensitive, ...
Breaking Biology Technology:Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Swell new sensors 2
... ISELIN, N.J., July 30 SyntheMed, Inc. (OTC ... development and commercialization of anti-adhesion products, announced today that ... its bioresorbable reverse thermal gelation polymer technology. This ... this novel technology and pertains to the application of ...
... , MONMOUTH JUNCTION, N.J., July ... into a cooperative research and development agreement with the National ... National Institutes of Health (NIH), to study ARIKACE(TM) (liposomal amikacin ... , , Transave and NIAID will collaborate ...
... , CHADDS FORD, Pa., July 30 Endo Pharmaceuticals ... quarter of 2009, including a full quarter of results of Indevus Pharmaceuticals, ... Total revenues during the second quarter of 2009 increased 22 percent ... 2008. Net income for the three months ended June 30, 2009, ...
Cached Biology Technology:SyntheMed Receives US Patent on Novel Polymer Technology 2Transave Enters Into Cooperative Research Agreement With NIH To Study ARIKACE(TM) In Nontuberculous Mycobacteria 2Transave Enters Into Cooperative Research Agreement With NIH To Study ARIKACE(TM) In Nontuberculous Mycobacteria 3Transave Enters Into Cooperative Research Agreement With NIH To Study ARIKACE(TM) In Nontuberculous Mycobacteria 4Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 2Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 3Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 4Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 5Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 6Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 7Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 8Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 9Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 10Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 11Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 12Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 13Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 14Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 15Endo Pharmaceuticals Reports Strong Second Quarter 2009 Financial Results 16
SHEEP ANTI BOVINE LACTOPEROXIDASE...
... in utility and flexibility press-to-seal silicone isolators ... of the researcher. They are available either ... sheet material that can be easily trimmed ... autoclavable and non-cytotoxic and can be used ...
Request Info...
... Provides up to 30 minutes of walkaway time. Automatic Calibration. Five minute cooldown ... port. ... ... ...
Biology Products: