Navigation Links
Gene, stem cell therapy only needs to be 50 percent effective to create a healthy heart
Date:10/31/2007

COLUMBIA, Mo. Heart disease is the leading cause of death in the United States and greatly affects the quality and length of life for individuals with specific forms of muscular dystrophy. Recent discoveries have demonstrated that gene and/or stem cell therapy could help a variety of organs in the body, but until now scientists have been unsure whether the heart could benefit from these treatments. According to a new study, recently published in Circulation Research, a journal of the American Heart Association, University of Missouri-Columbia researchers have demonstrated that a muscular dystrophy patient should be able to maintain a normal lifestyle if only 50 percent of the cells of the heart are healthy.

Patients with Duchenne muscular dystrophy and Becker muscular dystrophy have a gene mutation that disrupts the production of a protein known as dystrophin. Absence of this protein starts a chain reaction that eventually leads to muscle cell degeneration and death. Eventually, the damaged muscle tissue is replaced by fibrous, bony or fatty tissue and loses function. In the heart, this leads to severe heart disease and can place severe limitations on individuals afflicted with the disease.

In the past, scientists believed that the only way to have a healthy heart was to rid the heart of all damaged tissue. The heart is considered to be a synchronized organ; therefore, it was believed that the heart needed to maintain 100 percent normal cells in order to stay healthy.

In gene therapy, mutated genes are replaced with healthy genes. In stem cell therapy, diseased cells are replaced with healthy cells. However, in these gene and stem cell therapies, it is not feasible to fix every cell in the heart. Previously, scientists were uncertain whether partial correction could benefit patients.

In our study, we found that a heart with 50 percent normal cells looks like a normal heart, said Dongsheng Duan, an associate professor of mo
'/>"/>

Contact: Christian Basi
BasiC@missouri.edu
573-882-4430
University of Missouri-Columbia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Silence the gene, save the cell: RNA interference as promising therapy for ALS
2. Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers
3. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
4. Columbia research lifts major hurdle to gene therapy for cancer
5. Combination therapy boosts effectiveness of telomere-directed cancer cell death
6. Gene therapy converts dead bone graft to new, living tissue
7. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
8. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
9. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
10. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
11. Gene Therapy For Parkinsons Disease Moves Forward In Animals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... simple spheres of fluid, not normally considered capable of ... made droplets of alcohol move through water. In the ... able to move on your own to be ... organisms. But also non-living entities can be self-moving, report ... Chemical Technology in Prague, Czech Republic. , The researchers ...
(Date:9/29/2014)... This news release is available in French . ... 29th, 2014 - The number of days an expectant ... (1998) predicts the epigenetic profile of her child, a ... University Institute and McGill University have detected a distinctive ... aftermath of the massive Quebec ice storm. Five months ...
(Date:9/29/2014)... with Multiple Sclerosis (MS) were able to safely tolerate ... to a study published today in the journal ... is the first of its kind, was conducted by ... Celgene Corporation and collaborators at several other institutions. ... early signals in the data also suggested that a ...
Breaking Biology News(10 mins):Scientists make droplets move on their own 2Cells from placentas safe for patients with multiple sclerosis 2
... (Santa Barbara, Calif.) New research at UC Santa Barbara ... develop. The study is part of the campus,s expanding vision ... versions of The Proceedings of the National Academy of ... (IOVS). The scientists document how they used mice ...
... the collaboration of the Spanish Foundation for Biodiversity, the Charter ... the AZTI-Tecnalia R+D Centre will be studying the re-stocking of ... the months of May, June and July, respectively, in three ... gather the information needed to be able to manage the ...
... This release is available in German . ... research in Germany, the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) ... was taken by the appropriate Grants Committee in Bonn. The ... four and half years, during which time they will receive ...
Cached Biology News:UCSB scientists make strides in vision research 2A study will enable the survival and growth of the 3 development phases of the European eel 2DFG establishes 18 new research training groups 2DFG establishes 18 new research training groups 3DFG establishes 18 new research training groups 4DFG establishes 18 new research training groups 5DFG establishes 18 new research training groups 6DFG establishes 18 new research training groups 7DFG establishes 18 new research training groups 8DFG establishes 18 new research training groups 9DFG establishes 18 new research training groups 10
(Date:9/30/2014)... On September 11, Pharma IQ conducted an interview with ... session that he will lead on “Stem Cells” at the ... 2015 in London. In the interview posted online ... respond to several questions on the current state of technologies ... toxicity, and future trends in the use of stem cells ...
(Date:9/29/2014)... 2014 Each year in the ... medical attention. In the military, burn injury is ... battlefield medical care. More than 800 service members ... wounds heal slowly, remain inflamed and often become ... debilitating and functionally damaging. While developments in supportive ...
(Date:9/29/2014)... /PRNewswire/ - Portage Biotech Inc. ("Portage" or "the Company") (OTC: ... that its three Promissory Note holders, two of whom ... each in July 2014 for a total of $ ... converted into 3,500,001 restricted common shares. Notes were repayable ... Note and the coupon were convertible into common shares ...
(Date:9/29/2014)... Transparency Market Research, in its report ... HPPS, by Application - Cancer, Metabolic, CVS, CNS & ... Delivery) - Global Industry Analysis, Size, Share, Growth, Trends ... peptide therapeutics market was worth US$14.1 billion in 2011 ... at an 8.7% CAGR. , The two main types ...
Breaking Biology Technology:Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 2Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 3Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 4Faster Healing with Fewer Scars 2Portage announces conversion of its debt into equity 2Portage announces conversion of its debt into equity 3Global Peptide Therapeutics Market to be Worth US$25.4 Billion by 2018: Transparency Market Research 2Global Peptide Therapeutics Market to be Worth US$25.4 Billion by 2018: Transparency Market Research 3
... MILWAUKEEThe growing popularity of digital music recorders, digital ... Brady Corporation 's recent acquisition of ID ... manufacturer and supplier of pressure sensitive die-cut components ... Brady Asia-Pacific Allan Klotsche, this acquisition, along with ...
... In order to surpass its original goal for life-long learning ... (ADL) Co-Laboratory has plans to move from University Research Park ... will make the move Sept. 1, a bit behind ... While delays in the approval processes are to blame for ...
... recently announced it received a Phase I small business ... Cancer Institute . , ,The grant, according to chief executive ... rapidly measure the activity of enzymes that are relevant to ... could develop a way to quickly quantify enzyme activity that ...
Cached Biology Technology:Brady continues growth through Asian acquisition 2Academic ADL Co-Lab moving to downtown Madison 2Academic ADL Co-Lab moving to downtown Madison 3
... were designed for full-length gene cloning and ... identify the desired cDNA clone. The first ... "Master Plate," where each well contains plasmid ... positive well(s) by gel electrophoresis of the ...
... Panels were designed for full-length gene cloning ... to identify the desired cDNA clone. The ... 96-well "Master Plate," where each well contains ... the positive well(s) by gel electrophoresis of ...
... Prepared by a modification of the ... Biotechnol. Bioeng., 11 , ... will yield an A 260 ... water (1 cm light path). Physical ...
... Dithiothreitol DTT White solid.. PACKAGED UNDER ... thiols, so reaction is "driven" to completion. A ... waxy surfactant found in many other preparations. Blocks ... Purity: ≥97% by titration. Contaminants: Heavy ...
Biology Products: