Navigation Links
Gamma interferon a wake-up call for stem cell response to infection
Date:6/8/2010

of the immune system, we are finding fundamental ways in which the immune response affects bone marrow. This is the first time that anyone has extensively studied hematopoietic stem cells in the context of an in vivo model (a living organism) of infection."

"As a specialist in infectious diseases, I see many patients whose bone marrow no longer produces sufficient blood cells as a consequence of their infection. This is particularly relevant in chronic infections such as mycobacterial diseases (that include tuberculosis) and AIDS," said King. "Our studies lend insight into the causes of this decrease in bone marrow function during such infections, and I hope the work will someday lead to new therapies."

Studies in mice with a chronic or long-term infection called Mycobacterium avium show that a greater proportion of a particular subset of their cells called long-term hematopoietic (blood-forming) stem cells are active. Gamma interferon prompts this activity. Mice that lack gamma interferon have fewer of these stem cells active during infection.

These findings show that gamma interferon not only activates stem cells during infection, but also regulate stem cells in normal times, enabling them to maintain the types of blood cells that exist in proportion or homeostasis.

"Our model predicts that bacterial infection detected by sentinel immune cells stimulates the increased release of gamma interferon, which then travels through the blood stream to activate HSCs (hematopoietic stem cells) in the bone marrow, leading to expansion and mobilization of the immune progenitor pool (the cells that ultimately produce immune system cells)," the researchers wrote.

They found that sustained activity by the hematopoietic stem cells can lead to at least transient problems with the quality of the stem cells and their abilities to stimulate production of more immune system cells.

"One of the most important things we found is th
'/>"/>

Contact: Glenna Picton
picton@gmail.com
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Gamma interferon could aid fight against fungal infections
2. Gamma globulin effective in treating eye infections caused by adenoviruses
3. The right response to every pathogen
4. Bacterioplankton responses to desert dust in the (sub)tropical northeast Atlantic
5. Receptor variant influences dopamine response to alcohol
6. Cheese found to improve the immune response of the elderly
7. NASA deploys planes, targets satellites to aid in oil spill response
8. Study links 1976 swine flu shot to stronger immune response to 21st century pandemic flu
9. Chronix Biomedicals serum DNA assays monitor disease activity and treatment response in MS
10. Rapid response team investigates coral disease outbreak in Kaneohe Bay, Oahu
11. Discovery that PARP protein exists in all breast tumors will help target chemo and predict response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... A leading U.S. Ebola researcher from the University of Texas ... a blend of three monoclonal antibodies can completely protect monkeys ... days after infection, at a time when the disease is ... written an editorial for Nature discussing advances in ... Marburg virus are among the most deadly of pathogens, with ...
(Date:8/29/2014)... German . ... considered the oldest form of communication. Acting as messenger ... the sexual attraction between males and females. Fish rely ... reproductive behavior in males and females. Scientists at the ... in Faro, Portugal, and at the Max Planck Institute ...
(Date:8/29/2014)... of the Tibetan plateau -- the largest topographic anomaly ... both its profound effect on climate and its reflection ... GSA Bulletin , Katharine Huntington and colleagues employ a ... modern and fossil snail shells to investigate the uplift ... , Views range widely on the timing of surface ...
Breaking Biology News(10 mins):Leading Ebola researcher at UTMB says there's an effective treatment for Ebola 2Ready for mating at the right time 2Ready for mating at the right time 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7
... of researchers from the Hawai,i Institute of Marine Biology ... and zooxanthellae as part of a hybrid web application ... and ecosystem information on symbiotic zooxanthellae called Symbiodinium ... the cells of other marine organisms like anemones, jellyfish, ...
... safe to say Northern Illinois University Biological Sciences Professor Virginia ... at her Hampshire, Ill. home. She also has focused her ... -- the prehistoric saber-tooths. Naples and two colleagues -- ... John Babiarz -- are editors of a new book on ...
... City Physicians preparing to deliver a baby look at ... or not to perform a C- section. But a new ... that those heart rate patterns may not be a good ... to unnecessary interventions and higher costs. "We,re trying to ...
Cached Biology News:An online global map of coral and zooxanthellae data for climate change study is released 2An online global map of coral and zooxanthellae data for climate change study is released 3NIU biologist Virginia Naples is helping put new face on ferocious saber-tooth cats 2NIU biologist Virginia Naples is helping put new face on ferocious saber-tooth cats 3New study finds fetal heart rate not a good indicator of a baby's health 2New study finds fetal heart rate not a good indicator of a baby's health 3
(Date:8/29/2014)... New York (PRWEB) August 29, 2014 ... valued at $5.6 billion in 2019. It is ... from 2013 to 2019, and was valued at ... report published by Transparency Market Research. , For ... visit: http://www.transparencymarketresearch.com/companion-diagnostics-market.html . , The research report, ...
(Date:8/29/2014)... Three Lawrence Livermore researchers have received ... R&D Award for their research in producing ... , Shared with collaborators from the National Renewable ... Las Vegas (UNLV), the award recognizes the team ... production and corrosion processes. , These models have ...
(Date:8/28/2014)... 2014 Best Sanitizers, Inc., a leader ... processing industry, is asking industry professionals to prepare for ... the E2 soap they’re currently using to the Best ... Hand hygiene is critical to fighting cross-contamination and ... Six key criteria are identified to evaluate the effectiveness ...
(Date:8/28/2014)... Aug. 28, 2014 ... market research report is available ... Whole Exome Sequencing Market by ... Target Enrichment), by Services (Sequencing), ... by Application (Cancer, Monogenic disorders) ...
Breaking Biology Technology:Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3Livermore Team Awarded for Hydrogen Production Research 2Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 3Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 4Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 5Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 6Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 7Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 8Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 9Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 10Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 11Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 12Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 13
... SolvayCARES Thriving Student ... -, MARIETTA, Ga., Sept. 15 Solvay Pharmaceuticals, ... with,cystic fibrosis (CF) through its SolvayCARES Scholarship program. Each,student ... finance,post-secondary education. This fall, one SolvayCARES Scholarship winner,will go ...
... Modigene Inc.,(OTC Bulletin Board: MODG), a biopharmaceutical ... of already approved,therapeutic proteins, today announced that President ... Life Sciences Conference at 2:00 PM EDT,on September ... company,s presentation will be webcast live.,It can be ...
... QC, Sept. 15 /PRNewswire-FirstCall/ - Neptune Technologies ... today,that its distributor Schiff Nutrition International Inc. ... (NKO(R)) in Walgreens,which represents the largest retail ... 6,400 drug stores nationwide. Schiff(R) MegaRed(TM) has ...
Cached Biology Technology:40 High-Achieving Students with Cystic Fibrosis Receive $100,000 Total in Higher Education Scholarships From SolvayCARES(SM) 240 High-Achieving Students with Cystic Fibrosis Receive $100,000 Total in Higher Education Scholarships From SolvayCARES(SM) 340 High-Achieving Students with Cystic Fibrosis Receive $100,000 Total in Higher Education Scholarships From SolvayCARES(SM) 4Neptune Krill Oil, NKO(R), enters WALGREENS, the largest U.S. retail pharmacy chain, under the brand name Schiff(R) MegaRed(TM) 2Neptune Krill Oil, NKO(R), enters WALGREENS, the largest U.S. retail pharmacy chain, under the brand name Schiff(R) MegaRed(TM) 3
... Label Transfer Sulfo SBED Protein:Protein Interaction Reagent ... Label Transfer has rapidly gained traction as ... discovery. A growing number of publications feature ... Transfer Reagent to study a variety of ...
... is a compact benchtop and stackable ... controller with a large display screen ... speed. Air circulation inside to evenly ... can be easily calibrated from the ...
... siTrio siRNA --- a cocktail of 3 ... of interestis our most popular product. The ... 75% knockdown of your target gene when ... for transfection and confirmation of optimal transfection ...
... siTrio siRNA --- a cocktail of 3 ... of interestis our most popular product. The ... 75% knockdown of your target gene when ... for transfection and confirmation of optimal transfection ...
Biology Products: