Navigation Links
Gamma interferon a wake-up call for stem cell response to infection
Date:6/8/2010

HOUSTON -- (June 10, 2010) Most of the time, the body's blood-forming (hematopoietic) stem cells remain dormant, with just a few producing blood cells and maintaining a balance among the different types.

However, invading bacteria can be a call-to-arms, awaking the sleeping stem cells and prompting them to produce immune system cells that fight the foreign organisms. The "bugler" that awakes the stem cells in this battle is gamma interferon, a front-line protein defender against bacterial infection, said researchers from Baylor College of Medicine (www.bcm.edu) in a report that appears in the current issue of the journal Nature (www.nature.com).

"We are looking at the normal function of stem cells," said Dr. Margaret Goodell (www.bcm.edu/star/index.cfm?pmid=2947), professor of molecular and human genetics at BCM and director of the Stem Cells and Regenerative Medicine (STaR) (www.bcm.edu/star/index.cfm?PMID=0) Center. She is the report's senior author. "One of those is to respond to an infection."

Goodell and her colleagues knew that cells farther along in the differentiation process responded to infection, increasing the production of immune cells.

"We were sure there was a mechanism by which hematopoietic stem cells respond to infection, but it was not obvious," she said. They started their work with gamma interferon because they knew it played an important role in bacterial infection.

The collaboration and talents of two researchers in her laboratory first co-authors Drs. Megan T. Baldridge and Katherine Y. King facilitated the work with mice that led to this finding, said Goodell. Both are at BCM.

"I think our findings represent an exciting new avenue for studying hematopoiesis," said King. "By viewing the hematopoietic stem cell as the source
'/>"/>

Contact: Glenna Picton
picton@gmail.com
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Gamma interferon could aid fight against fungal infections
2. Gamma globulin effective in treating eye infections caused by adenoviruses
3. The right response to every pathogen
4. Bacterioplankton responses to desert dust in the (sub)tropical northeast Atlantic
5. Receptor variant influences dopamine response to alcohol
6. Cheese found to improve the immune response of the elderly
7. NASA deploys planes, targets satellites to aid in oil spill response
8. Study links 1976 swine flu shot to stronger immune response to 21st century pandemic flu
9. Chronix Biomedicals serum DNA assays monitor disease activity and treatment response in MS
10. Rapid response team investigates coral disease outbreak in Kaneohe Bay, Oahu
11. Discovery that PARP protein exists in all breast tumors will help target chemo and predict response
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... normal circumstances, astrocytes participate in normal physiological ... exhibit therapeutic and repairing effects on brain ... found that nerve cells differentiated from adipose-derived ... viability, which produces influences on subsequent studies ... Hospital, Hebei United University, China demonstrated that ...
(Date:7/11/2014)... Research and Markets has announced ... - Industry Analysis Size Share Growth Trends and Forecast ... http://photos.prnewswire.com/prnh/20130307/600769 The rising ... need for high level security in both private and ... as username and passwords, tokens etc. are vulnerable to ...
(Date:7/11/2014)... brains of all vertebrates, information is transmitted through ... chemical signal to be passed from one brain ... most abundant type of synapse, can be either ... learning, memory, perception and cognition, and the balance ... function. For instance, every time we learn ...
Breaking Biology News(10 mins):International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2Blame it on the astrocytes 2
... ROCKVILLE, Md. -- The American Society of ... America COMPETES Act. Originally enacted in 2007, ... in Technology, Education, and Science (COMPETES) Act underscored ... technology, engineering, and mathematics education. Among other ...
... surprise to many that quails are able to distinguish one ... quails. Nevertheless, it has long been known that disruption ... group within the UMR 6552 at the CNRS-Universit de Rennes ... on the behavioural development of their offspring. Together with ...
... high quality chocolate, and the farmers who grow it, will ... tree genome, according to an international team led by Claire ... and including scientists from 18 other institutions. The team ... , considered to produce the world,s finest chocolate. The Maya ...
Cached Biology News:Parents' social problems affect their children -- even in birds 2'Food of the gods' genome sequence could make finest chocolate better 2'Food of the gods' genome sequence could make finest chocolate better 3
(Date:7/10/2014)... research may help in the fight against terrorism with ... quantities of explosives with the use of light and ... Sensors and Actuators B: Chemical , the researchers describe ... in concentrations as low as 6.3 ppm (parts per ... few minutes. , "Traditionally explosives detection has involved looking ...
(Date:7/10/2014)... published today in the journal PNAS (Proceedings of ... time of day and sleep deprivation have a significant ... when looking at the best time of day to ... and for administering medicines effectively. , Researchers from the ... London, investigated the links between sleep deprivation, body clock ...
(Date:7/10/2014)... quantum Hall effect in bilayer graphene and shown that ... an electric field. , The fractional quantum Hall ... sheets are exposed to large magnetic fields, is a ... electrons behave as a single system. However, while the ... details of this collective behavior remain not well understood, ...
(Date:7/10/2014)... upside down forever. Nanophysics makes sure of that. Mechanics researchers ... published in Physical Review E . Knowledge that can ... seem to be able to sit still forever, and walk ... We will soon be able to buy smart new fasteners ... the fact is, sooner or later the grip is lost, ...
Breaking Biology Technology:Detecting trace amounts of explosives with light 2Time of day crucial to accurately test for diseases, new research finds 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3Even geckos can lose their grip 2
... Mass., April 2, 2008 Joseph F. Finn,Jr., CPA, ... today the completion of the sale of ActivBiotics intellectual,property ... Rifalazil, a,Phase II antibiotic, 2) a library of novel ... (SODm) and a library of SODm,small molecules., Mr. ...
... Company to Seek Buyer for Marketed Product Ganite(R), Lloyd ... BERKELEY HEIGHTS, N.J., April 2, 2008 Genta,Incorporated ... has,restructured certain of its operations to conserve cash and ... the Company,received notice that its appeal of an adverse ...
... 2008 Pharmaceutical,companies currently challenged with replacing the ... patent in the next four years must dramatically,rethink ... a new report,released by Deloitte today., According ... R&D in the Future,Pharmaceutical Landscape (http://www.deloitte.com/us/FuturePharma ), ...
Cached Biology Technology:Genta Restructures Operations to Focus on Priority Initiatives 2Genta Restructures Operations to Focus on Priority Initiatives 3Genta Restructures Operations to Focus on Priority Initiatives 4As Billions in Blockbuster Drug Revenue Goes Off Patent, Life Sciences Companies are Challenged to Fundamentally Change Future R&D Strategies, According to New Deloitte Report 2As Billions in Blockbuster Drug Revenue Goes Off Patent, Life Sciences Companies are Challenged to Fundamentally Change Future R&D Strategies, According to New Deloitte Report 3
...
... AgarACE Enzyme(a) is a unique agarose-digesting ... quantitative recovery of intact DNA or RNA ... thermostable that low melting point (LMP) agarose ... be equilibrated to the reaction temperature before ...
... Terminal deoxynucleotidyl transferase (TdT) is an ... in cortical thymocytes and minor subpopulation of ... enzyme and increased numbers of TdT cells ... lymphoblastic leukaemias and lymphomas. Presence of TdT ...
Request Info...
Biology Products: