Navigation Links
Gamma globulin effective in treating eye infections caused by adenoviruses
Date:8/28/2007

ains of adenovirus, and the same concentration of Ig also neutralized almost 90 percent of the various adenovirus subtypes isolated from patients with eye infections.

In the animal (in vivo) studies using topical Ig, all of the animals tested tolerated the Ig extremely well, without displaying any irritation even at high dosages. More importantly, Ig neutralized adenovirus at least as well as cidofovir, another antiviral drug that proved to be a potent inhibitor of adenovirus eye infections in early trials but was never approved by the FDA due to unacceptable side effects. According to the investigators, Ig was remarkably effective, during the early phase of infection (days 1-5) as demonstrated by the significant reduction in daily levels of virus in eye fluids compared to eye fluids obtained from control animals administered only saline.

Although this is the first study to ever demonstrate Igs ability to block adenoviral-mediated eye infections, Dr. Gambotto is only slightly surprised by the results. We use this compound in our laboratory on a regular basis to block the activity of the adenoviruses that we use in gene therapy experiments. So, we were pretty sure it would have some antiviral effects. We were not prepared, however, for it to be effective against so many strains and to demonstrate almost no toxicity, he explained.

Because conjunctivitis is so contagious, Dr. Gambotto and his investigators believe that topical Ig may be of value in many settings, including ophthalmology units in hospitals, pediatric units, community clinics and in global public health programs. Furthermore, due to its broad spectrum of antimicrobial properties, they believe that topical ocular application of Ig may be effective against other viral and bacterial causes of conjunctivitis.


'/>"/>

Contact: Jim Swyers
SwyersJP@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Combination therapy boosts effectiveness of telomere-directed cancer cell death
2. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
3. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
4. Boosting HIV screening can increase survival and is cost effective
5. Effective Cancer Treatments Follow The Clock
6. Live vaccines more effective against horse herpes virus
7. FDA Works To Speed The Advent Of New, More Effective Personalized Medicines
8. Man-made wetlands effectiveness similar to natural marsh
9. Wake Forest scientists find new combination vaccine effective against plague
10. UCLA study assesses cost-effectiveness of Hepatitis B drugs
11. Fungus Effective Against Winged Termites
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2009)The body is a battle zone. Cells constantly compete with one another for space and dominance. Though the manner in which some cells win this competition is well known to be the survival of the fittest
(Date:12/4/2009)By measuring the total gene activity in organs relevant for coronary artery disease (CAD), scientists at the Swedish medical university Karolinska Institutet have identified a module of genes that is
(Date:12/4/2009)This release is available in German . , A new study of the Max Planck Institute for Biology of Ageing could help to understand the positive effect of dietary restriction on healthy ageing. Previou
Breaking Biology News(10 mins):Stem cells battle for space 2Scientists discover gene module underlying atherosclerosis development 2How nutrition affects healthy aging 2Tumor attacking virus strikes with one two punch 10941 1Tumor attacking virus strikes with one two punch 10941 2North Pole wolf emails locations to researchers 10938 1North Pole wolf emails locations to researchers 10938 2North Pole wolf emails locations to researchers 10938 3Exercise May Lead to a Smarter More Successful You 62353 1Exercise May Lead to a Smarter More Successful You 62353 2Exercise May Lead to a Smarter More Successful You 62353 3
... has found that one of the cell,s largest families... known to regulate the development of nerve cells,...ical chemicals and proteins for learning and memor...ar semaphores to this important nerve cell functio... published in advance at the journal,s website on ...
...ege of Forestry at Oregon State University have de...onize a large portion of the wood products industr...enefits. , The discovery has already resulted in t...ge of new products. But it was originally based on...stant professor, who was harvesting mussels one da...
...day announced the launch of MedScan?Text-to-Knowle... tool for automated extraction of biological facts...d other text sources. A demo version of MedScan is...everages hand-crafted dictionaries of protein and ...rn matching algorithms specifically developed for ...
Other Biology News:Structure-building cell signals also may influence learning and memory 2Structure-building cell signals also may influence learning and memory 3Nature provides inspiration for important new adhesive 2Nature provides inspiration for important new adhesive 3 Software Tool for Converting Scientific Text into a Database of Functional Relationships 2
(Date:12/3/2009)DALLAS, Dec. 3 ACCESS PHARMACEUTICALS, INC. (OTC Bulletin Board: ACCP), today provided an update on its European commercial launch of MuGard, an FDA approved treatment for oral mucositis, a deb
(Date:12/3/2009)WALTHAM, Mass., Dec. 3 Inverness Medical Innovations, Inc. (NYSE: IMA ), a global leader in enabling individuals to take charge of their health at home through the merger of rapid diagnostics and h
(Date:12/2/2009)MANILA, Philippines, Dec. 2 Spectrum Blue Steel is emerging as one of the fastest growing green energy companies on the planet. Through the efforts of True Green Energy Group and True Green Planet,s
(Date:12/2/2009)NEW YORK, Dec. 2 Nearly 600 medical research executives, scientists, policy makers, and funders today convened to explore novel development approaches and innovative funding strategies at the inaugur
Breaking Biology Technology:Access Pharmaceuticals Provides Update on MuGard Commercial Launch in Europe 2Access Pharmaceuticals Provides Update on MuGard Commercial Launch in Europe 3Access Pharmaceuticals Provides Update on MuGard Commercial Launch in Europe 4Spectrum Blue Steel partners with Famous Chemists for Procuring Profitable Applications from Garbage Using the Biosphere MKV and Electrostatic Precipitators 2Spectrum Blue Steel partners with Famous Chemists for Procuring Profitable Applications from Garbage Using the Biosphere MKV and Electrostatic Precipitators 3Medical Research Leaders Explore Novel Strategies to Expedite the Search for Cures 2
...A, Md., Jan. 8 Northwest Biotherapeutics, Inc. (O..."Company" or "NWBT") announced today settlement of...e Northwest Biotherapeutics, Inc. Securities Lit...ed to pay in settlement US$1 million, which is to ...nt must be approved by the Court. Additional deta...
... ALTOS, Calif., Jan. 8 InteKrin Therapeutics, Inc... Healthcare Conference at,9:00 a.m. Pacific Time o...tin,St. Francis in San Francisco, California. Inte... will present at the conference. , About InteK...erapeutics is a privately-held clinical stage biop...
...BRIDGE, Mass., Jan. 8 /PRNewswire/ -- The Nano S...unced that the Nanotech Conference & Expo 2009...own Convention Center, in Houston, Texas. Now in ...technology event is expected to attract a communit...y executives, who will gather to promote advanced ...
Other Biology Technology:Northwest Biotherapeutics Settles Class Action Complaint, and SEC Investigation Closed Without Action 2Northwest Biotherapeutics Settles Class Action Complaint, and SEC Investigation Closed Without Action 3InteKrin Therapeutics to Present at the 27th Annual JP Morgan Healthcare Conference on Tuesday, January 13 2NSTI Announces the 12th Annual Nanotech Conference & Expo 2009 May 3-7, at the George R. Brown Convention Center in Houston, Texas 2NSTI Announces the 12th Annual Nanotech Conference & Expo 2009 May 3-7, at the George R. Brown Convention Center in Houston, Texas 3NSTI Announces the 12th Annual Nanotech Conference & Expo 2009 May 3-7, at the George R. Brown Convention Center in Houston, Texas 4
...ia cardiac puncture from 3 to 4 week old rabbits (...ged and frozen at -70C. The complement is thawed, ...ored at -70C. DIRECT SALES FROM PEL-FREEZ BIOLOGIC... YOU CAN NOW BUY DIRECTLY FROM THE SOURCE! FORMER ...
Thermal Grayscale USB Printer for Imaging Systems; USB Connection from Alpha Innotech
GIBCO Newborn Calf Serum Heat-Inactivated from Invitrogen
Ready-To-Use IHC Bluing Reagent from Bethyl Laboratories
Biology Products: