Navigation Links
Game of two halves leads to brain asymmetry
Date:1/14/2009

A tug-of-war between the two sides of the brain causes it to become asymmetrical, according to research published today in the journal Neuron. Asymmetry in the brain is thought to be important to enable the two hemispheres to specialise and operate more efficiently.

Left-right asymmetry is present in the brains of most animals and is first evident at the time of early brain development. However, until now, scientists did not know the mechanisms that bring it about. Now, in a study funded primarily by the Wellcome Trust, researchers have shown that a competition between the two sides causes this asymmetry.

By studying brain development in zebrafish, PhD student Jenny Regan and her colleagues in Professor Stephen Wilson's team at UCL (University College London) have shown that a protein known as Fgf8 acts as a magnet to attract nerve cells to one side of the brain. .

"Fgf8 is found in both sides of the brain, leading to a 'tug-of-war' competition between the two sides to attract the migrating group of nerve cells," says Dr Regan. "This isn't a fair fight, however Fgf8 on the left-hand side has an ally to help it win the battle."

A second protein, known as Nodal, is present only on the left and teams up with Fgf8 to attract the group of nerve cells, triggering a cascade of events that lead to asymmetric development of the brain, with neurons on the left making different connections to those on the right. The combined action of Fgf8 and Nodal ensures that when the asymmetry develops, it is usually in the same direction this helps to explain why there is consistent handedness between individuals. Nodal is known to also play a role in other areas of the body where asymmetry occurs, such as the heart and positioning of internal organs.

If Nodal is inhibited, the competition is fairer and the group of nerve cells has an equal probability of migrating to the right or left side, but a bias in the direction of migrat
'/>"/>

Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study of placenta unexpectedly leads to cancer gene
2. Mayo Clinic research on tamoxifen leads to recommendation for CYP2D6 gene test
3. Personalized medicine: Innovative online journal leads the way
4. TECNALIA leads five projects within the VII Framework Program
5. Exposing chicks to maternal stress leads to long-term reproductive success
6. How neuronal activity leads to Alzheimers protein cleavage
7. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
8. Childrens national co-leads nationwide study of landmark sickle cell treatment
9. USC researchers identify alternate pathway that leads to palate development
10. Small research at MSU leads to advances in energy, electronics
11. 1 missing gene leads to fruitless mating rituals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... UK 19 August 2014: An engineer at the ... despite not having a brain to communicate with the ... Harvard, Professor L Mahadevan, has developed a mathematical model ... view of how these soft bodied animals get around. ... the central pattern generator (CPG) which states that the ...
(Date:8/19/2014)... to treat pain, but its effect on pain ... a recent study reported on the Neural ... rat models of an avulsion injury to the ... neuropathic pain) were given electroacupuncture stimulation at bilateral ... (GB34). After electroacupuncture therapy, chronic neuropathic pain in ...
(Date:8/19/2014)... exist in different forms, they have not been widely ... Now researchers from the University of Surrey and Trinity ... elastic bands with graphene, to create a flexible sensor ... be made cheaply. , Once treated, the rubber ... graphene - which imparts an electromechanical response on movement ...
Breaking Biology News(10 mins):Secrets of how worms wriggle uncovered 2
... by Professor Hans-Georg Kräusslich at Heidelberg University Hospitals, ... Tumor Virology of the Deutsches Krebsforschungszentrum (German Cancer ... label Human Immunodeficiency Viruses (HIV) for visual investigations ... , The labeling permits scientists to observe the ...
... bugs, according to Gilbert Waldbauer, whose book "Insights From Insects: ... (Prometheus Books). , "We know a lot about pests, because ... professor emeritus of entomology at the University of Illinois at ... 2 percent are considered pests. Just as some plants growing ...
... synthesis of QS-21A, a medicinally important molecule that helps ... at the University of Illinois at Urbana-Champaign. , In ... the body's immune response in vaccine therapies against aggressive ... prostate cancer, HIV-1 and malaria. An extract from the ...
Cached Biology News:Virologists make major step towards understanding the process of HIV infection 2Bugs, even 'bad' ones, can be educationally beneficial, new book says 2Bugs, even 'bad' ones, can be educationally beneficial, new book says 3
(Date:8/19/2014)... Aug. 19, 2014 Research and Markets  has ... (SOFCs) - Global Strategic Business Report" report to their ... for Solid Oxide Fuel Cells (SOFCs) in US$ Thousands. The ... Canada , Europe , ... forecasts are provided for the period 2012 through 2020. Market ...
(Date:8/19/2014)... 2012, the European Union (EU) mandated use of the ICH-recommended ... – responding to the increasing need to understand and manage ... many regions, the main objectives of the PBRER are to:, ... of new or emerging information on the risks of a ... potential benefits of a drug; and , Allow ...
(Date:8/18/2014)... new therapy developed by researchers at the University ... and Columbia University Medical Center (CUMC) may help ... treatment. , The researchers demonstrated in a ... selectively inhibit blood vessel re-narrowing and simultaneously promote ... balloon catheter to open narrowed or blocked arteries. ...
(Date:8/18/2014)... August 18, 2014 Global HIV Infection ... report announced by Reportstack. The rate of HIV infection and ... a declining note at a positive rate across the globe. ... 2.3 million in 2005 to 1.5 in 2013, with the ... for such drastic changes in the infection rates has been ...
Breaking Biology Technology:Global Solid Oxide Fuel Cells (SOFCs) - Strategic Business Report 2014 2Top Five Best Practices for Developing Your Periodic Benefit Risk Evaluation Report (PBRER), New Webinar Hosted by Xtalks 2Selective therapy may improve artery repair after interventional cardiovascular procedures 2Selective therapy may improve artery repair after interventional cardiovascular procedures 3Global HIV Infection Drug Market Overview 2Global HIV Infection Drug Market Overview 3Global HIV Infection Drug Market Overview 4
... are continually reaching new lows as they reduce the temperatures ... low enough to overcome the entropy (a measure of the ... discovery of exotic states of ultra-cold matter. Now physicists at ... out of a collection of atoms in much the same ...
... Oncolytics Biotech Inc. (TSX: ONC, NASDAQ: ONCY ... Hardev Pandha of the Royal Surrey County Hospital, U.K., ... of Clinical Cancer Research. The paper is entitled "Synergistic ... Malignant Melanoma." , The research demonstrated that the innate ...
... , CAMBRIDGE, Mass., Sept. 24 Peptimmune, Inc. ... has formed a research and development collaboration with the Walter ... Research Center (NMRC), Silver Spring, MD to evaluate the Company,s ... dengue vaccines and point-of-care diagnostics. , , ...
Cached Biology Technology:Oncolytics Biotech(R) Inc. Announces Reovirus and Cisplatin Research Supports U.S. Phase 2 Metastatic Melanoma Trial 2Peptimmune to Collaborate on Dengue Virus Vaccine and Point-Of-Care Diagnostic With Two DOD Biomedical Research Facilities 2
Negative Control, eluted and packaged aseptically in 20l of 10mM Tris-HCL, pH 8.0, 1 mM EDTA, 5 years at either 4°C or -20°C...
AdestaTM Tissue/Cell Preservation Medium Sterile / Non-sterile: Sterility Tested Endotoxin: ...
...
... Clone/PAD: ZMD.440. Immunogen: Synthetic peptide derived ... PDGF-D (platelet derived growth factor D iris-expressed ... which differs from mouse and rat by ... with the ~50 kDa human mouse and ...
Biology Products: