Navigation Links
Gallo Center scientists identify key brain circuits that control compulsive drinking in rats
Date:7/22/2013

hs per year.

The drinking rats showed a notable increase in the NMDA receptor (NMDAR), which lead author Taban Seif, PhD, a Gallo Center researcher, called a molecule that excites the brain. When the rats were injected with an NMDAR blocker, their consumption of quinine-laced alcohol dropped significantly, while regular alcohol use was unaffected. In other words, only the compulsive drinking was affected, said Seif.

The team then focused its research on connections from two specific regions of the rats prefrontal cortex where they had discovered the presence of unusual types of NMDARs: the medial prefrontal cortex, which mediates conflict during decision-making, and the insula, which is critical for self-awareness and feelings. In a non-addict, these brain areas tell you when something is potentially harmful and bad, and to run away as fast as possible, said Hopf. But if youre a compulsive drinker, it seems instead that they give you a comforting pat on the back, in effect telling you its OK to have another drink, nothing to worry about.

Using a technique called optogenetics, the scientists inserted halorhodopsin, a light-sensitive protein, into these areas. They then used fiber-optic cables implanted in the rats brains to send pulses of laser light that activated the halorhodopsin, which in turn inhibited the regions connections to the nucleus accumbens. The researchers found that rats inhibited in this way drank significantly less quinine-laced alcohol, while their intake of regular alcohol solution remained unaffected.

The fact that we reduced the rats compulsive drinking using two different methods an NMDAR blocker and direct inhibition of connections tells us that we have probably identified the right areas, said Hopf.

The next logical step for the research team, said Hopf, would be to work with clinical researchers on an NMDAR blocker trial in human subjects.

What is interesting is t
'/>"/>

Contact: Jeffrey Norris
jeff.norris@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. BGI and Association of Czech genetic centers announce opening of a joint prenatal test facility
2. UChicago Celiac Disease Center to host international symposium
3. MIT and Wilson Center receive NSF grant to develop synthetic biology research agenda
4. Emory, Georgia Tech receive first human exposome center grant in US
5. U-M Water Center awards $570K in Great Lakes restoration grants
6. NSF approves planning grant for Center for Advanced Research in Drying
7. Center for Clinical and Translational Science awards new pilot grants
8. University of Maryland Medical Center launches genetic-testing program for cardiac patients
9. Intermountain Medical Center reseachers develop new 3-D technology to treat atrial fibrillation
10. NYU Langone Medical Center researcher named Howard Hughes Investigator
11. Scientists discover how brains auditory center transmits information for decisions, actions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/14/2014)... LA JOLLA, CA – October 14, 2014 – Scientists ... $6.6 million from the National Institutes of Health (NIH) ... most prevalent virus-induced hemorrhagic fever disease in Africa. The ... disease and why some patients die, while others survive ... researchers to understand the basic mechanism of how Lassa ...
(Date:10/14/2014)... team of researchers, led by the Chinese Academy of ... Nature Genetics a brief genomic history of tomato ... tomato plant. , The C.M. Rick Tomato Genetics Resource ... this study by providing seed of both cultivated tomato ... builds on the first tomato genome sequence completed just ...
(Date:10/14/2014)... October 14, 2014 – Over the past decades, we ... institutions to meet the needs of infants for social ... these infants to thrive. , Infancy and ... of the cortex. A generation of research suggests that ... cortical development and cognitive function. In contrast, deprivation and ...
Breaking Biology News(10 mins):Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2Institutional rearing may increase risk attention-deficit disorder 2
... less be as simple as leaving serving dishes on the stove ... from Cornell University, it can. At this week,s ... director of the Cornell Food and Brand Lab, shared findings of ... "We looked at whether serving foods from the kitchen counter, instead ...
... and CAMBRIDGE (April 26, 2010) Pericytes, the contractile ... angiogenesis, the "sprouting" of new blood vessels, according to ... the Massachusetts Institute of Technology (MIT). The study, published ... among the first to examine mechanical signaling by pericytes ...
... A new study links progression of a lethal type ... immune system genes, suggesting how complex the immune response is ... immune system proteins for treatment. Previous research found ... with this type of brain cancer, called glioblastoma multiforme. However, ...
Cached Biology News:Cellular mechanical forces may initiate angiogenesis 2Brain tumor growth linked to lowered expression of hundreds of immune function genes 2Brain tumor growth linked to lowered expression of hundreds of immune function genes 3
(Date:10/19/2014)... The Asia-Pacific Bromine Market report defines ... analysis and forecast of revenue. , Browse through ... report, to get an idea of the in-depth ... the segmentation in the Asia-Pacific bromine market, and ... , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine is a ...
(Date:10/19/2014)... The report "Chocolate, Cocoa Beans, Lecithin, ... Geography Trend and Forecast (2011 - 2016)," analyzes ... and studies the major market drivers, restraints, and opportunities ... Asia. , The global chocolate market is expected to ... 2016 at an estimated CAGR of 2.7% from 2011 ...
(Date:10/19/2014)... 2014 According to market research ... WLAN Controllers; Wireless gateways)]- Global Advancements, Forecasts and ... global Outdoor Wi-Fi market with analysis and forecasting ... also identifies the drivers and the restrains for ... opportunities and challenges. , Browse 65 market data ...
(Date:10/18/2014)... 2014 The report "1,6-Hexanediol Market ... Forecasts to 2019", analyzes the global market on ... understand the industry details such as the key ... geographic regions. , Browse 81 Market Data Tables ... in-depth TOC on “1,6-Hexanediol Market by Application and ...
Breaking Biology Technology:The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 2Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5
... chooses AMICAS to drive improvements in customer ... service and operational efficiency, ... leader in radiology and medical image and information management,solutions, today ... California,s most influential radiology groups., (Logo: http://www.newscom.com/cgi-bin/prnh/20060202/AMICASLOGO ...
... July 28 Ranbaxy,Pharmaceuticals Inc. (RPI), a ... Gurgaon, India announced today that under an,agreement ... authorized,generic of Omeprazole 40 mg Capsules in ... indicated for the treatment of acid-related disease,including ...
... Pa., July 25 BioTrends Research Group, Inc.,released ... offering comprehensive insight into the management of,renal anemia ... Disease,(CKD) and Dialysis. The report provides information from ... online survey fielded in,June 2008., In the ...
Cached Biology Technology:Arcadia Radiology Medical Group Chooses AMICAS 2Arcadia Radiology Medical Group Chooses AMICAS 3Ranbaxy Launches Omeprazole 40 mg Capsules 2BioTrends Releases Quarterly TreatmentTrends(TM): Nephrology Report Highlighting Market Trends for Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism 2BioTrends Releases Quarterly TreatmentTrends(TM): Nephrology Report Highlighting Market Trends for Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism 3
... 23 years of experience in the development ... antibodies to large and small peptides, proteins, ... plasmid DNA-encoded antigens. We understand and appreciate ... hybridoma development programs are never "cookbook". We ...
... The Rapid-Screen cDNA Library Panels were ... just three sets of PCRs to identify ... analysis is performed in a 96-well "Master ... from 5,000 clones. Having identified the positive ...
... The Rapid-Screen cDNA Library Panels were ... just three sets of PCRs to identify ... analysis is performed in a 96-well "Master ... from 5,000 clones. Having identified the positive ...
... The ProteoSpin CBED Maxi Kit provides ... volumes of dilute protein solutions for buffer exchange, ... protein samples. The kit is based on spin-column ... ion exchanger. Salts such as MgCl 2 , ...
Biology Products: