Navigation Links
Gallbladder cancer may be linked to estrogens, says UH team
Date:8/16/2010

HOUSTON, Aug. 16, 2010 A very aggressive disease with a poor prognosis, gallbladder cancer may be connected to higher exposure to estrogens, according to a group of researchers at the University of Houston (UH).

Dr. Jan-ke Gustafsson, Robert A. Welch Professor in UH's biology and biochemistry department, described his team's findings in a paper titled "Estrogen-dependent gallbladder carcinogenesis in LXRβ-/- female mice" appearing in a recent issue of the journal Proceedings of the National Academy of Sciences, one of the world's most-cited multidisciplinary scientific serials.

"For the first time, we show in this paper that the absence of liver X beta receptors, or LXRβ, in a complex interplay with estrogens, induces gallbladder cancer exclusively in female mice," Gustafsson said. "Interestingly, the elimination of estrogens prevents the development of tumors in this animal model."

In the study, the team found that chronic inflammatory gall bladder disease characteristic of LXRβ-/- mice, led to gallbladder lesions that developed and evolved into cancer in older female mice. It is known that metabolic and hormonal alterations have been associated with this invasive disease, and LXRβ is a sensor for cholesterol derivatives. By removing the ovaries and reducing estrogen levels, the researchers were able to prevent the development of tumors in LXRβ-/- mice.

There are many crucial clinical implications resulting from these findings. First, drugs that decrease the level of estrogens might be added to the conventional treatment of gallbladder cancer. And, in the long term, pharmacological activators of LXRβ could become potential new anti-cancer drugs that may reduce or regulate the proliferation of gallbladder cells.

Additionally, in looking at families affected by hereditary gallbladder cancers, this research could shed light upon mutations in the sequence of LXRβ that may be responsible for this particular cancer, indicating a higher risk for this disease. This, in turn, could one day be used to determine individual risks.

"Going forward, we need to estimate exactly the levels of LXRβ and its activators in human gallbladder cancers, particularly in female patients," Gustafsson said. "Once the presence and the function of LXRβ in the human gallbladder are clear, we are going to test the potential effects of LXRβ molecules on human gallbladder cancer cells."

In addition to Gustafsson, the UH team on this project consists of post-doctoral students Drs. Chiara Gabbi, who made the discovery, Hyun-Jin Kim and Rodrigo Barros, as well as biology and biochemistry professor Margaret Warner, who has worked with the Gustafsson group since 1986. Marion Korach-Andre' from the Center for Biosciences at the Karolinska Institute in Sweden also contributed to this study.


'/>"/>

Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

Related biology news :

1. Robo-surgery: As safe and capable as a human assistant in key-hole gallbladder removal
2. Breast cancer treatment resistance linked to signaling pathway
3. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
4. The dietary supplement genistein can undermine breast cancer treatment
5. Saliva proteins could help detection of oral cancer
6. Vitamin C supplements may reduce benefit from wide range of anti-cancer drugs
7. Breakthrough optical technology to assess colon cancer risk, accuracy
8. Breast cancer cells recycle to escape death by hormonal therapy
9. Nanodiamond drug device could transform cancer treatment
10. Second lumpectomy for breast cancer reduces survival rates
11. Study looks at psychological impact of gene test for breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gallbladder cancer may be linked to estrogens, says UH team
(Date:12/8/2016)... Dec. 8, 2016 Market Research Future published a half ... global Mobile Biometric Security and Service Market is expected to grow ... Market Highlights: ... , Mobile Biometric Security and ... the increasing need of authentication and security from unwanted cyber threats. ...
(Date:12/7/2016)... According to a new market research report "Emotion Detection and Recognition Market by ... Area, End User, And Region - Global Forecast to 2021", published by MarketsandMarkets, ... to USD 36.07 Billion by 2021, at a Compound Annual Growth Rate (CAGR) ... ... MarketsandMarkets Logo ...
(Date:12/7/2016)...   Avanade is helping Williams Martini Racing, ... history, exploit biometric data in order to critically analyse ... competitive edge against their rivals after their impressive, record-breaking ... has worked with Williams during the 2016 season to ... rate, breathing rate, temperature and peak acceleration) for key ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... HOUSTON , Jan. 19, 2017 ... announced the formation of its Medical/Clinical Advisory Board. ... industry veterans who enhance the range and depth ... development of its novel prenatal diagnostic tests.  These ... and strategic guidance for the company,s product development ...
(Date:1/19/2017)... ... January 19, 2017 , ... November Research ... leading biopharmaceutical and medical device manufacturers and regulators, is proud to announce the ... 11-compliant email client designed to provide product vigilance departments with the flexibility and ...
(Date:1/19/2017)... ... January 18, 2017 , ... The American ... to update its Data Sharing Policy. Specifically, the nation’s leading informatics experts, said ... to the existing policy. AMIA recommended that NIH earmark funding for researchers to ...
(Date:1/19/2017)... 18, 2017 The global biotechnology services ... billion by 2025, according to a new report ... been adaptive of the function of outsourcing certain ... Among the services outsourced, clinical trial management and ... & Johnson was the first pharmaceutical company to ...
Breaking Biology Technology: