Navigation Links
Gabapentin inhibits central sensitization during migraine

Gabapentin is a gamma-aminobutyric acid derivative, and was approved for the treatment of neuropathic pain by the U.S. Food and Drug Administration in 2002. However, little evidence is available on the effects and me-chanisms of action of gabapentin during the migraine attack period. A recent study by Yanbo Zhang and colleague from Xuanwu Hospital, Capital Medical University in China showed that excitatory amino acids and protein kinase C are involved in the formation and maintenance of central sensitization during migraine. Gabapentin can decrease neuronal excitability in spinal trigeminal nuclei and inhibit the formation of central sensitization during migraine by reducing excitatory amino acid content in the cerebrospinal fluid and by inhibiting protein kinase C activation. These findings were published in the Neural Regeneration Research (Vol. 8, No. 32, 2013).


Contact: Meng Zhao
Neural Regeneration Research

Page: 1

Related biology news :

1. How the Parkin enzyme inhibits neuronal cell death
2. Active component from wine-processed Fructus corni inhibits hippocampal neuron apoptosis
3. Gene transduction inhibits post-epileptic hippocampal synaptic reconstruction
4. New agent inhibits HCV replication in mouse models -- No resistance seen
5. Molecule found that inhibits estrogen, key risk factor for endometrial and breast cancers
6. BGI scientists win BioMed Central Open Data Award
7. Richness mapping and prediction of amphibians in Southern and Central China
8. Research uncovers potential preventive for central line infection
9. New virus discovered in patients with central nervous system infections
10. Snap shots of 1 of lifes central processes
11. New evidence shows PubMed Central undermines journal usage
Post Your Comments:
Related Image:
Gabapentin inhibits central sensitization during migraine
(Date:11/11/2015)... , Nov. 11, 2015   MedNet Solutions , ... spectrum of clinical research, is pleased to announce that it ... Clinical Trials (PCT) event, to be held November 17-19 ... able to view live demonstrations of iMedNet ... learn how iMedNet has been able to deliver ...
(Date:11/4/2015)... , November 4, 2015 ... new market report published by Transparency Market Research "Home Security ... Trends and Forecast 2015 - 2022", the global home security ... 30.3 bn by 2022. The market is estimated to ... period from 2015 to 2022. Rising security needs among ...
(Date:10/29/2015)... , Oct. 29, 2015  Rubicon Genomics, ... for U.S. distribution of its DNA library preparation ... and Rubicon,s new ThruPLEX Plasma-seq kit. ThruPLEX Plasma-seq ... the preparation of NGS libraries for liquid biopsies--the ... diagnostic and prognostic applications in cancer and other ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... 2015 Studies reveal the differences ... and pave the way for more effective treatment for one ...   --> --> ... problems in cats, yet relatively little was understood about the ... have been conducted by researchers from the WALTHAM Centre for ...
(Date:11/25/2015)... DIEGO , Nov. 25, 2015  Neurocrine Biosciences, ... Kevin Gorman , President and CEO of Neurocrine Biosciences, ... Healthcare Conference in New York . ... to visit the website approximately 5 minutes prior to ... A replay of the presentation will be available on ...
(Date:11/25/2015)... IN (PRWEB) , ... November 25, 2015 , ... ... (AMA) and the Organization of Black Aerospace Professionals (OPBAP) has been formalized with ... and other AMA team leaders met with OPBAP leaders Capt. Karl Minter and ...
(Date:11/25/2015)... 2015 The Global Genomics ... professional and in-depth study on the current state ... ) , The report ... definitions, classifications, applications and industry chain structure. The ... markets including development trends, competitive landscape analysis, and ...
Breaking Biology Technology: