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GW researchers receive award from NCI to study cancer from a neglected tropical disease
Date:6/16/2011

ic areas along the Chi River basin in Northeastern Thailand (Isaan), the global epicenter of cholangiocarcinoma, and is currently following over 1,000 individuals identified to be at high risk of developing liver fluke-induced bile duct cancer.

"Cholangiocarcinoma is associated with a late presentation", said Dr. Brindley, "and, therefore, poses great challenges for diagnosis and has a high mortality rate. These features highlight the need for biomarkers than can be measured early and in accessible samples, such as plasma."

This project will be undertaken in cooperation with Dr. Banchob Sripa, head of the Tropical Disease Research Laboratory, Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand and Drs. Jason Mulvenna and Alexander Loukas, Queensland Tropical Health Alliance, James Cook University, Cairns, Australia.

"O. viverrini induced bile duct cancer provides a unique model of human carcinogenesis, with the major risk factor and many of the intermediate stages on the pathway to cancer already well-defined," Dr. Bethony said, "This enables us to track the presence of biomarkers from the initiation of cancer risk to culmination in bile duct cancer."


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Contact: Anne Banner
abanner@gwumc.edu
202-994-2261
George Washington University Medical Center
Source:Eurekalert

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