Navigation Links
GW researcher unlocks next step in creating HIV-1 immunotherapy using fossil virus
Date:7/17/2014

WASHINGTON (July 17, 2014) The road to finding a cure for HIV-1 is not without obstacles. However, thanks to cutting-edge research by Douglas Nixon, M.D., Ph.D., and colleagues, performed at the George Washington University (GW), Oregon Health & Science University, the University of Rochester, and UC San Francisco, the scientific community is one step closer to finding a viable immunotherapy option for HIV-1, using an immune attack against a fossil virus buried in the genome.

A major hurdle in eradicating HIV-1 has been outsmarting the frequent mutations, or changing coats of the virus caused by its high rate of replication. Researchers have focused on neutralizing antibodies directed against the HIV-1 envelope in order to stop the virus, but the antibodies haven't been able to keep up with this constant change. Nixon's research team found that the right antibody directed against an ancestral fossil virus buried within everyone's genomes might be able to target HIV-1 and neutralize it.

"What we've found is an antibody that recognizes these fossil viruses within all our genomes, which can neutralize HIV-1 in a way that has never been seen before," said Nixon, chair of the Department of Microbiology, Immunology, and Tropical Medicine at the GW School of Medicine and Health Sciences. "We have found in vitro, in the test tube, that you can actually have an antibody work against HIV-1, which is not directed against the HIV-1 virus itself."

In his research, Nixon and colleagues found that by targeting the fossil virus an ancestral version of a retrovirus that has become a largely useless part of our DNA that these antibodies could focus on a single fixed envelope, as it does not change like the constant changes of HIV-1's envelope outer coat. This discovery provides a new, therapeutic target to beat this particular coat, or variation.


'/>"/>

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert

Related biology news :

1. Duck migration study reveals importance of conserving wetlands, MU researchers find
2. Researchers advance understanding in immune response to infectious disease
3. Researchers find organic pollutants not factor in turtle tumor disease
4. Largest International Meeting for the Study of Reproductive Biology Attracts Researchers from 36 Countries in Grand Rapids, Michigan
5. Little too late: Researchers identify disease that may have plagued 700-year-old skeleton
6. MUHC researcher unveils novel treatment for a form of childhood blindness
7. Researchers declassify dinosaurs as being the great-great-grandparents of birds
8. IPCC must consider alternate policy views, researchers say
9. Science and cookies: Researchers tap into citizen science to shed light on ant diversity
10. Researchers receive $12.6 million NIH grant to study genetics of Alzheimers
11. Researchers uncover new knowledge about our intestines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... , April 15, 2016 ... "Global Gait Biometrics Market 2016-2020,"  report to their ... ) , ,The global gait biometrics market ... 13.98% during the period 2016-2020. Gait ... which can be used to compute factors that ...
(Date:4/13/2016)... physicians supporting Medicaid patients in Central Florida ... telehealth thanks to a new partnership with higi.   ... can routinely track key health measurements, such as blood ... they opt in, share them with IMPOWER clinicians through ... location at no cost. By leveraging this data, IMPOWER ...
(Date:3/31/2016)... 31, 2016  Genomics firm Nabsys has completed a ... Barrett Bready , M.D., who returned to the company ... technical leadership team, including Chief Technology Officer, John ... Steve Nurnberg and Vice President of Software and Informatics, ... Dr. Bready served as CEO of Nabsys ...
Breaking Biology News(10 mins):
(Date:5/19/2016)... , May 19, 2016  AdvancedFlow Systems ... Inc. (AGI), based out of Maple ... Biogas Ltd. to its existing portfolio of contract ... agreement. AFS along with its sister companies Surround ... a vertically integrated industrial group that specializes in ...
(Date:5/19/2016)... - I dati saranno presentati nel ... ° Congresso della Società Americana di Oncologia ... conclusioni dello studio indicano un tasso di risposta del 56% ... presenta una d urata della risposta (Duration Of Response, ... dei pazienti ha riscontrato un beneficio clinico.      ...
(Date:5/18/2016)... , ... May 18, 2016 , ... STACS DNA Inc., ... to easily track and report sexual assault kit processing to help them save time ... as pressure escalates for kits to be processed and victims informed of results. Due ...
(Date:5/17/2016)... 2016 Haselmeier announces the launch ... approval by EMA, the European Medicines Agency. Originally launched ... company, the new pen version includes enhancements to further ... confidence to patients during use. Its enhanced ... to handle with a larger display window that improves ...
Breaking Biology Technology: