WASHINGTON (July 24, 2014)The link between autism and disrupted brain development is an essential part of the puzzle of the disease, and is largely unknown. However, thanks to funding from the Simons Foundation Autism Research Initiative (SFARI), George Washington University (GW) researcher Anthony-Samuel LaMantia, Ph.D. may be able to offer truly integrative and in-depth answers to these key questions in the field of autism research.
LaMantia, professor of pharmacology and physiology at the GW School of Medicine and Health Sciences (SMHS), was awarded $739K from SFARI for his promising research on a key class of nerve cells found in the cerebral cortex, which is the part of the brain that performs many key functions disrupted in autism, particularly social interaction, communication, and cognition.
SFARI is a leading funder of autism research in the U.S. The prestigious SFARI research grants support cutting edge research at several research institutions. The SFARI research grant received by LaMantia and colleagues is the first such award at GW.
LaMantia and his research team, which includes interdisciplinary collaborators from GW and the University of Pennsylvania School of Medicine, will first look at how these nerve cells are generated from cortical stem cells during prenatal development. They will then look at connections made between these nerve cells in one cortical area with nerve cells in other cortical areas. The connections between these nerve cells have been suggested to be either diminished or increased based on imaging studies in patients with autism spectrum disorders (ASD). There is no clear indication, however, what cortical neurons make the abnormal connections, and whether under- or over-connectivity is related to autism pathology.
"Everybody agrees that sometime during development, the way the cerebral cortex is wired gets disrupted in autistic patients and that this is a key reason for the difficulties i
|Contact: Lisa Anderson|
George Washington University