Navigation Links
GW researcher discovers new regulatory autism gene
Date:7/1/2013

WASHINGTON -- A new study by Valerie Hu, Ph.D., professor of biochemistry and molecular medicine at the George Washington University (GW) School of Medicine and Health Sciences (SMHS), reports that RORA, a novel candidate gene for autism discovered by her group in a 2010 study, regulates a large number of other genes associated with autism.

"We are focusing on this gene, in part, because this gene can act as a master regulator of other genes," said Hu, whose study was published in the journal Molecular Autism.

"Called nuclear hormone receptors, they are capable of activating or suppressing other genes in the genome. The question was which specific genes are regulated by RORA."

Hu and co-author, Tewarit Sarachana, Ph.D., a former doctoral student in the molecular medicine doctoral program at SMHS, found that RORA encodes a protein that can regulate the expression of more than 2,500 other genes. Of these 2,500 genes, many are known to be involved in neuronal development and functions, and 426 of RORA's gene targets are already listed in AutismKB, a database of known autism candidate genes.

To identify genes regulated by RORA, Hu and Sarachana used chromatin immunoprecipitation (ChIP) with an anti-RORA antibody followed by whole-genome promoter array (chip) analysis. This genome-wide ChIP-on-chip analysis of target genes of RORA, as well as additional methods of validation, confirmed that RORA transcriptionally regulates the genes A2BP1, CYP19A1, HSD17B10, ITPR1, NLGN1, and NTRK2, such that when RORA levels are cut in half, all six genes also go down in their expression. The expression levels of these six genes are also reduced in RORA-deficient postmortem brain tissues from individuals with autism relative to that of age-matched unaffected controls.

"We see it as a domino effect, where RORA is a particularly shaky domino," said Hu. "If knocked over, it can also knock down a whole bunch of other genes, except t
'/>"/>

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
4. U of Alberta researcher steps closer to understand autoimmune diseases
5. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
6. UNH researchers find African farmers need better climate change data to improve farming practices
7. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
8. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
9. Researchers print live cells with a standard inkjet printer
10. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
11. Researchers reveal how a single gene mutation leads to uncontrolled obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Most of North America,s megafauna mastodons, short-faced bears, ... horses disappeared close to 13,000 years ago at ... this massive extinction has long been debated by scientists ... , A group of scientists, including UC Santa Barbara,s ... Science, posited that a comet collision with Earth played ...
(Date:8/27/2014)... Orange, NJ. August 27, 2014. Using functional near ... differential brain activation patterns between people with multiple ... first MS study in which brain activation was ... task. The article, "Neuroimaging and cognition using functional ... published online on June 11 by Brain ...
(Date:8/27/2014)... Duke University researchers have identified a gene that could ... encodes a protein in the cell membrane of plants ... plant,s water conservation machinery accordingly. , "It,s similar ... of biology at Duke. , The findings, which ... could make it easier to feed the world,s growing ...
Breaking Biology News(10 mins):Nanodiamonds are forever 2Nanodiamonds are forever 3Kessler Foundation researchers publish first study of brain activation in MS using fNIRS 2Water 'thermostat' could help engineer drought-resistant crops 2
... normally reside on the skin of healthy people can ... researchers at the Swedish medical university Karolinska Institutet have ... of staphylococcus can attach itself to the skin and ... self-adhesive hairballs. Staphylococcus establishes itself on ...
... a seminar at another institution several years ago, ... hostile question: Why bother classifying organisms according to ... dynamics, when molecular techniques had already invalidated that ... in the audience nodding their agreement, Jablonski, the ...
... Israeli start-up company, launched its first "solar farm" near Tel ... developed by Prof. David Faiman of Ben-Gurion University of ... Faiman, who is chairman of the Department of Solar ... Desert Research, believes the new system will harvest more than ...
Cached Biology News:Tufted bacteria cause infection in premature babies 2Analysis finds strong match between molecular, fossil data in evolutionary studies 2Ben-Gurion University research and technology used in new solar energy farm 2
(Date:8/28/2014)... CA (PRWEB) August 28, 2014 ... is offering a promotion for Eppendorf Safe ... customers to purchase the highest quality tubes at ... are ideal for customers doing chemical, medical, pharmaceutical, ... technicians who are not regularly able to afford ...
(Date:8/27/2014)... Austin, TX (PRWEB) August 27, 2014 ... $6 million in Series B funding and secured Otter ... and investment capital will accelerate commercialization of GGI’s Agriplier™ ... multiple crop types. , “Since our first meeting, ... commitment to the biological product space,” said Alan Sobba, ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com ... is available in its catalogue: ... http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html ... materials that are readily decomposed by the ... conventional non-degradable packaging in terms of raw ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 The Global ... in-depth study on the current state of the Trifluoroacetic ... provides a basic overview of the industry, including definitions, ... Chinese domestic market analysis are provided with a focus ... market. A comparison between the international and Chinese situation ...
Breaking Biology Technology:Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7Trifluoroacetic Acid Industry (Asia, Europe, North America, ROW) Analysis Report Now Available at ReportsnReports.com 2
... Ga., March 23 ArunA Biomedical, Inc., ... of Edina, MN, giving Neuromics the right to ... Neural Cells and Neural Culture Medium to support ... )ArunA has an exclusive worldwide license to develop ...
... veteran journalist Bill Scanlon has joined the company to ... addition to the staff marks a significant evolution in ... will aid in the introduction of the public to ... experience in science, medical and business writing to NanoLogix, ...
... Lends Experience To Antimicrobial Leader.SHREVEPORT, La., March 23 ... authorities in the poultry industry, has joined SteriFx ... expertise to SteriFx, a leader in developing non-toxic ... healthcare, defense and other industries. "We,re honored and ...
Cached Biology Technology:ArunA Biomedical, Inc. Announces Alliance with Neuromics for Distribution of Normal Human Neural Cells 2NanoLogix Adds Noted Journalist Bill Scanlon to Provide Media Relations 2Dan Blackshear Joins SteriFx Inc. 2