Navigation Links
GW professor to examine infections in HIV patients with federal grant
Date:11/26/2012

WASHINGTON (Nov. 26, 2012) Imtiaz A. Khan, M.D., professor of microbiology, immunology, and tropical medicine at the George Washington University School of Medicine and Health Sciences, received a $1.6 million federal grant from the National Institute of Allergy and Infectious Diseases to study the effects of microsporidiaopportunistic inter-cellular pathogensthat cause morbidity and mortality in HIV patients.

Fifteen years ago, Khan saw that this type of infection was becoming a major problem in HIV populations. He realized little had been researched about immune response to these pathogens. After looking into the matter further, he saw that CD8+ T cells played a critical role in protecting against these pathogens.

His project, titled "CD8+ T cell effectors against microsporidia," will study how to prevent microsporidia from causing complications in immunocompromised subjects by regulating CD8+ T cells. These highly understudied cells are tolerated and controlled in healthy, immunocompetent individuals. For the elderly or individuals with HIV, these cells can cause problems. In order to stave off infection for the immunocompromised, the cells need to be maintained and regenerated.

"The question is, how can you generate CD8 effectively, so this infection does not harm them?" said Khan. "Because CD8+ T cells are critical, how can you maintain a good CD8 cell population, so this group of pathogens doesn't reemerge?"

Khan and his research team will be using cytokines and other therapeutic methods to generate highly functional CD8+ T cells to create and maintain robust immunity against these pathogens, improving the mortality and quality of life of many HIV patients.

This research may not only benefit those suffering from microspordia, but can be extended to other infections effecting HIV populations, as well.


'/>"/>

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert

Page: 1

Related biology news :

1. Michael Barnett of Boston College named Professor of the Year for Massachusetts
2. NJIT professor promotes building material of millennium: Autoclave aerated concrete
3. The IPCC Report on Climate Change - Swedish professor Thomas Sterner selected as 1 of the experts
4. Louisiana Tech University professor earns national honor from Society of American Foresters
5. New book on physics principles by Wayne State professor explains life as we know it
6. SMU professor Louis Jacobs honored with prestigious award from Texas science teachers
7. Professor publishes on first-ever imaging of cells growing on spherical surfaces
8. UA engineering professor Shane Snyder to speak in Korea on international water quality
9. National herpetology society honors UT Arlington professor for discoveries
10. GW professor receives grant to study the role of genes in drug addiction
11. Professors Antarctica research shows potential king crab invasion
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... -- When we want to listen carefully to someone, ... second thing we do is stop moving altogether. This ... generated by our own movements. , This interplay between ... the brain. Indeed, indirect evidence has long suggested that ... the auditory cortex, which gives rise to our conscious ...
(Date:8/27/2014)... Aug. 27, 2014 /PRNewswire-iReach/ -- The IEEE Engineering in ... th Annual International Conference (EMBC,14), this year being ... Chicago, Illinois , from Tuesday, August ... leaders, students, and industry professionals in science, medicine, and ... http://photos.prnewswire.com/prnh/20140827/140333 This year,s conference ...
(Date:8/27/2014)... deadly disease that exists as five strains, none of ... strains is the Sudan ebolavirus (SUDV). Although not the ... illness, even as recently as 2012. In a new ... , researchers now report a possible therapy that could ... Dye, Sachdev Sidhu, Jonathan Lai and colleagues explain that ...
Breaking Biology News(10 mins):Stop and listen: Study shows how movement affects hearing 2Stop and listen: Study shows how movement affects hearing 3Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 2Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 3Potential therapy for the Sudan strain of Ebola could help contain some future outbreaks 2
... Do you want that in a pill or a shot? ... choice. The problem with administering many medications orally is that ... site in the gastrointestinal tract where the medicine can be ... by Brown University researchers could solve the problem by safely ...
... with common blood pressure medications may cause hypotension ... older patients, requiring hospitalization, according to a study ... Association Journal ) (pre-embargo link only) http://www.cmaj.ca/embargo/cmaj100702.pdf ... are among the most widely prescribed antibiotics, with ...
... Stanford University School of Medicine, in collaboration with BioParadox, ... plasma as a promising biologic treatment for myocardial infarction ... online in Cardiovascular Revascularization Medicine and will ... Therapy for Cardiovascular Disease at Columbia University Medical Center, ...
Cached Biology News:Magnetically controlled pill could boost body's absorption of drugs 2RevaTen platelet-rich plasma shows promise as potential treatment for heart attacks 2
(Date:8/27/2014)... 2014 Research and Markets  has announced ... Mass Spectrometer Industry Report 2014" report to their ... Mass Spectrometer Industry Report 2014 is a professional and ... isotope ratio mass spectrometer industry. The report ... classifications, applications and industry chain structure. The isotope ratio ...
(Date:8/27/2014)... Palm Beach County, Florida (PRWEB) August 27, 2014 ... & Company Inc. (SCI) is announcing the creation ... board’s priority is to take the SCI’s philosophy ... insuring the company’s research and development actions are ... interpretations. , This new Scientific Advisory Board provides ...
(Date:8/27/2014)... According to the 2013 Raw Material and ... and feel of markets for raw materials and ingredient ... push for more branded, science-backed products.” , Natural products ... growth in the last decade as consumers increasingly demand ... to fit a more ‘wellness’ lifestyle approach. Due ...
(Date:8/27/2014)... August 27, 2014 Budding Biomedical ... University School participated in the Scientific ... Reserve University’s School of Medicine . ... an unparalleled professional experience in the sciences and ... Medicine faculty and students for both academic and ...
Breaking Biology Technology:Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2New Sancilio & Company, Inc. Scientific Board 2New Sancilio & Company, Inc. Scientific Board 3Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 2Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 3Students at Cleveland's University School Conduct Biomedical Research at Case Western Reserve University’s School of Medicine 2
... Sept. 23 S*BIO Pte Ltd today announced ... will support the continued development of S*BIO,s clinical ... reflects the international investment community,s strong interest in ... clinical development and the quality of our various ...
... China, Sept. 22 /PRNewswire-Asia-FirstCall/ -- China Pharma Holdings, ... ), which develops, manufactures, and markets specialty pharmaceutical ... has successfully completed Phase I clinical trials of ... Cephalosporin continues to be the most widely prescribed ...
... VANCOUVER, Sept. 22 /PRNewswire-FirstCall/ - OncoGenex Pharmaceuticals, Inc. ... of results from a randomized Phase 2 trial ... results showed a survival benefit with the investigational ... cancer. The median overall survival for patients who ...
Cached Biology Technology:S*BIO Announces US$5 Million Investment by Mitsui Ventures 2S*BIO Announces US$5 Million Investment by Mitsui Ventures 3China Pharma Holdings, Inc. Successfully Completes Phase I Clinical Trials of New Anti-Drug-Resistance Antibiotic 2China Pharma Holdings, Inc. Successfully Completes Phase I Clinical Trials of New Anti-Drug-Resistance Antibiotic 3China Pharma Holdings, Inc. Successfully Completes Phase I Clinical Trials of New Anti-Drug-Resistance Antibiotic 4OncoGenex Pharmaceuticals, Inc. - Journal of Clinical Oncology Publishes Data from Randomized Phase 2 Custirsen Trial 2OncoGenex Pharmaceuticals, Inc. - Journal of Clinical Oncology Publishes Data from Randomized Phase 2 Custirsen Trial 3OncoGenex Pharmaceuticals, Inc. - Journal of Clinical Oncology Publishes Data from Randomized Phase 2 Custirsen Trial 4OncoGenex Pharmaceuticals, Inc. - Journal of Clinical Oncology Publishes Data from Randomized Phase 2 Custirsen Trial 5
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ID clarifier: ...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ID clarifier: ...
ID clarifier: With ethidium bromide (50 μg/ml)...
... in DMEM and harvested at the log phase ... antigens in their native forms, cells were fixed ... a 12-well (5 mm) adhesive coated slide, with ... attachment and to minimize background staining. Each ...
Biology Products: