Navigation Links
GW professor to examine infections in HIV patients with federal grant
Date:11/26/2012

WASHINGTON (Nov. 26, 2012) Imtiaz A. Khan, M.D., professor of microbiology, immunology, and tropical medicine at the George Washington University School of Medicine and Health Sciences, received a $1.6 million federal grant from the National Institute of Allergy and Infectious Diseases to study the effects of microsporidiaopportunistic inter-cellular pathogensthat cause morbidity and mortality in HIV patients.

Fifteen years ago, Khan saw that this type of infection was becoming a major problem in HIV populations. He realized little had been researched about immune response to these pathogens. After looking into the matter further, he saw that CD8+ T cells played a critical role in protecting against these pathogens.

His project, titled "CD8+ T cell effectors against microsporidia," will study how to prevent microsporidia from causing complications in immunocompromised subjects by regulating CD8+ T cells. These highly understudied cells are tolerated and controlled in healthy, immunocompetent individuals. For the elderly or individuals with HIV, these cells can cause problems. In order to stave off infection for the immunocompromised, the cells need to be maintained and regenerated.

"The question is, how can you generate CD8 effectively, so this infection does not harm them?" said Khan. "Because CD8+ T cells are critical, how can you maintain a good CD8 cell population, so this group of pathogens doesn't reemerge?"

Khan and his research team will be using cytokines and other therapeutic methods to generate highly functional CD8+ T cells to create and maintain robust immunity against these pathogens, improving the mortality and quality of life of many HIV patients.

This research may not only benefit those suffering from microspordia, but can be extended to other infections effecting HIV populations, as well.


'/>"/>

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert

Page: 1

Related biology news :

1. Michael Barnett of Boston College named Professor of the Year for Massachusetts
2. NJIT professor promotes building material of millennium: Autoclave aerated concrete
3. The IPCC Report on Climate Change - Swedish professor Thomas Sterner selected as 1 of the experts
4. Louisiana Tech University professor earns national honor from Society of American Foresters
5. New book on physics principles by Wayne State professor explains life as we know it
6. SMU professor Louis Jacobs honored with prestigious award from Texas science teachers
7. Professor publishes on first-ever imaging of cells growing on spherical surfaces
8. UA engineering professor Shane Snyder to speak in Korea on international water quality
9. National herpetology society honors UT Arlington professor for discoveries
10. GW professor receives grant to study the role of genes in drug addiction
11. Professors Antarctica research shows potential king crab invasion
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... First quarter 2016:   , Revenues amounted ... quarter of 2015 The gross margin was 49% (27) ... the operating margin was 40% (-13) Earnings per share ... operations was SEK 249.9 M (21.2) , Outlook   ... M. The operating margin for 2016 is estimated to ...
(Date:4/15/2016)... 2016  A new partnership announced today will ... decisions in a fraction of the time it ... high-value life insurance policies to consumers without requiring ... Force Diagnostics, rapid testing (A1C, Cotinine and HIV) ... pressure, weight, pulse, BMI, and activity data) available ...
(Date:3/31/2016)... 31, 2016   ... the "Company") LegacyXChange is excited to release ... soon to be launched online site for trading 100% ... ) will also provide potential shareholders a sense of ... to an industry that is notorious for fraud. The ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... HOUSTON , June 23, 2016 ... agreement with the Cy-Fair Sports Association to serve ... of the agreement, Houston Methodist Willowbrook will provide ... education and connectivity with association coaches, volunteers, athletes ... partner with the Cy-Fair Sports Association and to ...
(Date:6/23/2016)... FRANCISCO , June 23, 2016   EpiBiome ... has secured $1 million in debt financing from Silicon ... ramp up automation and to advance its drug development ... its new facility. "SVB has been an ... beyond the services a traditional bank would provide," said ...
(Date:6/23/2016)... , June 23, 2016 Apellis Pharmaceuticals, ... 1 clinical trials of its complement C3 inhibitor, ... and multiple ascending dose studies designed to assess ... of subcutaneous injection in healthy adult volunteers. ... either as a single dose (ranging from 45 ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... exhibiting at the Pennsylvania Convention Center and will showcase its product’s latest features ... will also be presenting a scientific poster on Disrupting Clinical Trials in The ...
Breaking Biology Technology: