Navigation Links
GW professor receives grant to study the role of genes in drug addiction
Date:8/29/2012

WASHINGTON (Aug 29, 2012) Norman H. Lee, Ph.D., professor of pharmacology at the George Washington University School of Medicine and Health Sciences (SMHS), received a total of $405,001 in grant funding from the National Institute on Drug Abuse (NIDA) to continue to study the correlation between genetics and susceptibility to drug abuse. The award will fund Lee's continuing research on drug addiction, titled "Conditional Dicer1 Manipulation to Study miRNA Involvement in Oploids Addiction," for the next two years.

Lee will act as co-principal investigator of the grant, using his expertise in genomics to collaborate with Gregory Elmer, Ph.D., behavioral geneticist at the University of Maryland School of Medicine. Their research will focus primarily on morphine addiction in mouse models. In previous research, the researchers placed mice in a self-administration chamber and taught them to press a lever a certain number of times to receive an injection of morphine, which stimulates the reward center of the brain. While one group of mice eventually stopped pressing the lever, another group continued to work harder and pressed the lever many more times in order to receive an injection of morphine. They found that in this group of mice, there was a significant change in the expression of genes involved in the architecture of neurons in the brain, leading this group to abuse the drug.

"We are asking the question, 'What is it about the brain in certain individuals that's changing and leading them to become more susceptible to abusing drugs, despite the adverse consequences?'" said Lee.

The researchers discovered that the changes occurring in the brain are due in large part to an enzyme being turned on, called Dicer. This enzyme then turns on the expression of small RNA molecules, called micro-RNA (miRNA), which are important for gene regulation. The miRNAs in turn dampen or turn off genes, which Lee believes leads the mice to continue to self-administer and abuse morphine. With this grant, they will be able to determine which genes the miRNAs are dampening or turning off and which are important for drug addiction.

By combining their expertise to study drug addiction, Lee and Elmer hope to find a way to therapeutically target the genes being turned off in an effort to treat drug addiction.

Lee's grant application was chosen during a review process at NIDA, which is an organization under the National Institute of Health.


'/>"/>
Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert  

Related biology news :

1. Professors Antarctica research shows potential king crab invasion
2. UA engineering professor uses aerospace materials to build endless pipeline
3. University of Tennessee professor releases weight management product
4. University of Illinois professor develops tool that helps dietitians deliver info clients need and can understand
5. Salk Professor Terrence Sejnowski receives IEEE Frank Rosenblatt Award
6. Professors essay is 1 of 10 in special issue of Daedalus
7. University of Tennessee professor wins worlds top prize for ecology, environmental science
8. Notre Dame establishes professorships in adult stem cell research
9. University of Tennessee professor receives funding for clean coal research
10. Normal bacterial makeup has huge implications for health, says CU professor
11. Purdue professor to speak before Congress about nanotechnology in brain treatment research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
GW professor receives grant to study the role of genes in drug addiction
(Date:6/23/2017)... ARMONK, N.Y. and ITHACA, N.Y. ... IBM ) and Cornell University, a leader in dairy ... combined with bioinformatics designed to help reduce the chances ... breaches. With the onset of this dairy project, Cornell ... the Consortium for Sequencing the Food Supply Chain, a ...
(Date:5/23/2017)... , May 23, 2017  Hunova, the first robotic gym for ... has been officially launched in Genoa, Italy . The ... and the USA . The technology was ... the market by the IIT spin-off Movendo Technology thanks to a 10 ... Multimedia News Release, please click: ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
Breaking Biology News(10 mins):
(Date:7/18/2017)... New Jersey (PRWEB) , ... July 18, 2017 , ... ... that aligns with your needs and has the capabilities to properly execute your job ... site customglassparts.com is a sourcing portal designed to showcase the company’s ...
(Date:7/18/2017)... ... July 18, 2017 , ... ... and has released the first phase of the Allotrope Framework for commercial use. ... Awards were created to “not only elevate the critical role of information technology ...
(Date:7/17/2017)... ... July 17, 2017 , ... ... software company AB Cube has joined its eHealth App xChange ™, ... innovation across life sciences and healthcare. Under the partnership, AB Cube’s comprehensive, ...
(Date:7/17/2017)... (PRWEB) , ... July 17, 2017 , ... ... diagnostics company that has developed and intends both to manufacture and sell reagents ... on the NASDAQ Capital Market. , Headquartered in Sandy, Utah, Co-Diagnostics’ intellectual property ...
Breaking Biology Technology: