Navigation Links
GW and Peking University awarded funding to understand common blood coagulation disorder
Date:7/15/2014

WASHINGTON -- The George Washington University (GW) School of Medicine and Health Sciences (SMHS) and The Peking University Medical College in Beijing, China are pleased to announce the award of significant funding for an international co-operative project to understand the molecular mechanisms of a very common blood coagulation disorder affecting both Americans and Chinese.

Research and medical teams from GW and Peking University Medical College will work together to apply the most sophisticated next-generation DNA/RNA sequencing to the problem of aspirin-insensitive thrombophilia. While aspirin is the most commonly used preventative therapy for heart disease, a certain fraction of subjects do not benefit from treatment, sometimes called aspirin resistance (AR).

In prior studies, GW scientists Drs. Tim McCaffrey, Sidney Fu, and Ian Toma in the Division of Genomic Medicine, worked closely with GW physicians Drs. Richard Katz, Jonathon Reiner, and Ramesh Mazhari, to identify RNA transcripts in blood that might help to explain this dangerous disease. It was known that patients with AR are up to 10 times more likely to have a heart attack than patients who respond normally to aspirin. That danger could be further increased when the patients undergo coronary stenting, which places a polymer coated wire mesh into the coronary arteries.

"This is a very important study that will improve the safety of many patients. By studying patients with AR, doctors will eventually be able identify a different course of treatment or prevention to be used for those with the disease," said McCaffrey, Ph.D., director of the Division of Genomic Medicine at SMHS.

Using sophisticated genomic microarrays, the GW team identified an interesting pattern of gene expression that suggested the coagulation disorder could be due to some type of autoimmune disease, in which the patient's own antibodies are attacking their blood platelets.

The GW team will work with physicians and scientists at Peking University, headed by Dr. Meilin Liu, a prominent cardiologist in the Department of Geriatrics of Peking University First Hospital, and an expert on cardiovascular complications in the elderly. In previous studies, a cardiovascular disease database has been initially established, which mainly collects the clinical information in the aging population. A proportion of patients exhibit insensitivity to long-term use of aspirin, giving them a higher risk of vascular events and stent restenosis, often requiring a second coronary angiogram.

Together, the U.S.-China teams will identify patients with AR and then analyze the mRNA expression patterns in blood using the most sophisticated RNA sequencing techniques available, providing a 'high resolution' view of the disease at the RNA level. The collaboration will take this research into the next phase of validating the RNA transcripts in a larger group of patients and analyzing additional medical parameters to help understand and diagnosis this dangerous condition.


'/>"/>
Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert

Related biology news :

1. Marshall University to partner with international company in drug development venture
2. Scorpions are master architects, according to new research from Ben-Gurion University
3. University of Strathclyde and NYU join in landmark research and academic partnership
4. Washington Universitys Joseph Jez is one of 15 million dollar professors
5. University of Tennessee discoveries could help neutralize chemical weapons
6. US housing policies increase carbon output, Georgia State University research finds
7. Mountain ecosystems scientists to convene at University of Nevada, Reno
8. University of Toronto biologists pave the way for improved epilepsy treatments
9. Chapman University partners with the Center for Autism and Related Disorders
10. Global health grant from the Bill & Melinda Gates Foundation awarded to the University of Surrey
11. Wayne State University licenses technology to new start-up, Detroit Materials, Inc.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... --  Bridge Patient Portal , an enterprise patient ... Systems , an electronic medical record solutions developer ... a partnership to build an interface between the ... products, including Centricity Practice Solution (CPS), Centricity Business ... integrations will allow healthcare delivery networks using GE ...
(Date:4/17/2017)... 17, 2017 NXT-ID, Inc. (NASDAQ: NXTD ... filing of its 2016 Annual Report on Form 10-K on Thursday ... ... available in the Investor Relations section of the Company,s website at ... website at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... No two people are believed to ... York University Tandon School of Engineering and Michigan ... partial similarities between prints are common enough that ... and other electronic devices can be more vulnerable ... in the fact that fingerprint-based authentication systems feature ...
Breaking Biology News(10 mins):
(Date:7/18/2017)... NJ (PRWEB) , ... July 18, 2017 , ... ... corporate finance technology, DataForm Software ( https://dataformsoftware.com ) announces the migration of its ... to Microsoft Azure. Planet is a team-centric, enterprise work management system that merges ...
(Date:7/17/2017)... Ca (PRWEB) , ... July 17, 2017 , ... ... and are characterized by a wide range of overlapping clinical features. The advancement ... discovery in the field of NDD research and testing. , However, designing ...
(Date:7/16/2017)... ... July 16, 2017 , ... OHAUS Corporation, a ... launch of its new line of Extreme Environment Shakers today. , Extreme Environment ... and humidity for optimal cell growth such as cell cultures, solubility studies and ...
(Date:7/14/2017)... USA/ Martinsried, Germany (PRWEB) , ... July 14, ... ... newly developed standardized solution for sample preparation of proteins to clean peptides for ... Diagenode Bioruptor® sonication system. , The PreOmics iST Kit is based on ...
Breaking Biology Technology: