Navigation Links
GUMC researchers find gene function 'lost' in melanoma and glioblastoma
Date:12/14/2008

Washington, D.C. Researchers at Georgetown University Medical Center have found a gene they say is inactivated in two aggressive cancers malignant melanoma, a form of skin cancer, and glioblastoma multiforme, a lethal brain tumor. They add that because this gene, known as PTPRD, has recently been found to be inactivated in several other cancers as well, their discovery suggests that PTPRD may play a tumor suppressor role in a wide variety of different cancers.

The findings are published in the December 15 issue of Cancer Research.

"Over the past decade several dozen tumor suppressor genes have been identified, but only a minority of them is important in causing many different tumor types. PTPRD seems to be one of these broad spectrum tumor suppressor genes," says the study's lead investigator, Todd Waldman, MD, PhD, an associate professor of oncology at Georgetown's Lombardi Comprehensive Cancer Center.

If the hypothesis is true and Waldman and his team are now investigating loss of PTPRD in a number of additional cancers then it may be possible to design a therapy that has wide applicability in oncology, he says.

"Most targeted cancer drugs today work by inhibiting gene products that are overactive in cancer cells. In this case, it is loss of the PTPRD gene that leads to cancer," Waldman says. "Therefore, we are trying to discover the molecules that PTPRD's protein controls, and then we plan to target these downstream molecules with a novel agent."

Waldman found that when the researchers restored production of the gene's protein in cancer cells that harbored PTPRD deletions or mutations, these tumors stopped growing and initiated a program of cell suicide.

The researchers also discovered PTPRD mutations in both the blood and in tumors of a patient with multiple different kinds of cancers. "This suggests that the gene could be responsible for an inherited predisposition to cancer," Waldman says


'/>"/>
Contact: Karen Mallet
km463@georgetown.edu
414-312-7085
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... , March 23, 2015  In the 2014 ... fraud case conviction losses. This figure accounts for a ... according to The Nilson Report, exceeds $11 billion globally. ... tool after a crime has occurred. Investor Mark ... polygraph expert Joe Paolella partnered to administer ...
(Date:3/20/2015)... Research and Markets ( http://www.researchandmarkets.com/research/4stcg3/india_sensors ... "India Sensors Market Forecast and Opportunities 2020" ... market is projected to grow at a CAGR ... automotive, industrial and healthcare sectors are the key ... addition, adoption of MEMS technology in sensors is ...
(Date:3/20/2015)... OXFORD, Conn. , March 20, 2015 ... "Company"), a biometric authentication company focused on the growing ... Wocket® smart wallet is one of the products featured ... today, March 20th at 11:00 PM EST on the ... travels to Las Vegas , site ...
Breaking Biology News(10 mins):Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3
... CORVALLIS, Ore. As oceans warm due to climate change, ... plankton that pump carbon out of the atmosphere but ... increase global warming or decrease it. The forces at ... University scientists in an article to be published Friday in ...
... evolutionary history of Antarctic fish and their "anti-freeze" proteins illustrates ... fish adapted to newly formed polar conditions and how ... temperatures. , "A rise of 2 degrees centigrade of water ... fish lineage, which is so well adapted to water at ...
... researchers are taking an historical approach to predict ... Robert van Woesik, professor of biological sciences, the ... into how these corals today may fare through ... past regional extinction events and modern coral vulnerability, ...
Cached Biology News:Ocean microbe communities changing, but long-term environmental impact is unclear 2Ocean microbe communities changing, but long-term environmental impact is unclear 3Fish of Antarctica threatened by climate change 2Coral survival's past is key to its future 2
(Date:4/28/2015)... 2015 The Pistoia Alliance, a global, ... to lower barriers to innovation in R&D, has announced ... , The Ontologies Mapping project has been set up ... ontology management in life sciences R&D. The project will ... guidelines, tools and services to enable the universal application ...
(Date:4/28/2015)... 2015 uBiome, Inc. has announced ... provide clinical tests based on its unique microbial ... startup sparked the era of microbiome-based personalized medicine ... accessible information about their own bodies using the ... microbiome. uBiome has gathered millions of data points ...
(Date:4/28/2015)... More than 50% of patients with ... over the course of their disease, and clinicians are ... the disease progresses. ReachMD , the 24/7 health ... a series dedicated to PD psychosis, featuring interviews and ... and psychiatric conditions. , The new series titled ...
(Date:4/28/2015)... April 28, 2015 IMS is ... bring it to the web and provide greater ... user friendly reporting metrics increase data warehouse’s utility; ... convenient recall and access “on-the-go” makes data analysis ... using client feedback to assist in repository analytics ...
Breaking Biology Technology:Pistoia Alliance Announces Start of Ontologies Mapping Project 2uBiome Launches Clinical Laboratory 2ReachMD Launches Series Focusing on Parkinson’s Disease Psychosis 2
... Directors,of Eli Lilly and Company (NYSE: LLY ) ... December 1, 2008. Oberhelman, 55, currently serves as,a group ... Caterpillar,s,executive office. As a member of Lilly,s board, Oberhelman ... committee. He will stand for,election by Lilly shareholders at ...
... KANNAPOLIS, N.C., Oct. 20 Academia, science, industry,and ... at 10,AM at the Dedication and Open House ... the UNC Nutrition Research Building and the NC,State ... Nutrition,Research Building is home to NC A&T University, ...
... Recruitment, and Employment Branding joins Pierpoint International as Global VP of ... ... (PRWEB) October 20, 2008 -- Pierpoint International is pleased to announce ... and Diversity. Mr. Cantu, most recently served as AVP of Staffing ...
Cached Biology Technology:Douglas Oberhelman Elected to Lilly Board of Directors 2Douglas Oberhelman Elected to Lilly Board of Directors 3Campus Celebrates Historic Milestone 2Campus Celebrates Historic Milestone 3Campus Celebrates Historic Milestone 4Campus Celebrates Historic Milestone 5Robert Cantu Appointed Vice President of Pierpoint International 2
... microarrays are custom designed to meet your ... available: 8,455 features per array (2 arrays/1" ... per array (1 array/slide). Features ... - This extended length delivers higher ...
... Agilent Two-Color RNA Spike-In Kit contains in ... only to complementary control probes on Agilents ... spike-ins serve as a positive microarray control ... NOTE: This kit is a required component ...
... Microarrays Using the New FAST(tm) Frame Multi-Slide ... is designed to hold four, 16-pad FAST ... in a microplate footprint for high throughput ... the standards recommended by the Society of ...
... pump, available in a single and twin head, ... design. With the most compact, lightweight package in ... in portable air and gas applications., Available ... T2-01TH). , Delivers 1.5 and 2.0 liters per ...
Biology Products: