Navigation Links
GUMC discovery highlights new direction for drug discovery
Date:7/5/2009

Washington, DC In a discovery that rebuffs conventional scientific thinking, researchers at Georgetown University Medical Center (GUMC) have discovered a novel way to block the activity of the fusion protein responsible for Ewing's sarcoma, a rare cancer found in children and young adults.

In the paper published online July 5 in Nature Medicine, they report discovering and successfully testing a small molecule that keeps the fusion protein from sticking to another protein that is critical for tumor formation. The researchers say this interaction is unique and is especially surprising since the Ewing's sarcoma fusion protein is extremely flexible, which allows it to change shape constantly.

"Most targeted small molecule cancer drugs inhibit the intrinsic activity of a single protein, but our agent stops two proteins from interacting. This has never been shown before with a cancer-causing fusion protein and represents a potentially novel medical therapy in the future," says the study's lead investigator, Jeffrey Toretsky, MD, a pediatric oncology physician and researcher at GUMC's Lombardi Comprehensive Cancer Center.

The study could provide a model upon which to design treatment for other disorders caused by the interaction between two proteins, and may be especially useful in cancers caused by translocations of genes, such as sarcomas and leukemias, the researchers say. Agents in use now that work against fusion proteins inhibit a single protein to stop intrinsic enzymatic activity; one example is Gleevec, used for chronic myelogenous leukemia (CML). The Ewing's sarcoma fusion protein, known as EWS-FLI1, lacks enzymatic activity, "and this difference is why our work is significant," Toretsky says.

In the United States, about 500 patients annually are diagnosed with the cancer, and they are treated with a combination of five different chemotherapy drugs. Between 60-70 percent of patients survive over time, but with
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Discovery may provide new treatments for alcohol dependence
2. New nanoparticles could revolutionize therapeutic drug discovery
3. Discovery of a water snake that startles fish in a way that makes them flee into its jaws
4. New discovery suggests mammoths survived in Britain until 14,000 years ago
5. Discovery of the cells water gate may lead to new cancer drugs
6. Aussie and Kiwi researchers make double MS genetic discovery
7. Discovery raises new doubts about dinosaur-bird links
8. NAU discovery could help feed millions
9. Voyages of discovery or necessity?
10. NASA Earth system science meeting celebrates 20 years of discovery
11. Cells split personality is a major discovery into neurological diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... to species, selection for traits that are attractive to ... enhances opportunities to mate, the tail of male peacocks ... of California, Riverside have now found that sexual selection ... are linked. Describing the life histories of more than ... researchers found that species with placentas tend to have ...
(Date:7/9/2014)... critically ill children with traumatic injuries have identified ... likely to develop a hospital-acquired infection. The study, ... published online in June in the journal ... that could lead to the clinical implementation of ... or reverse immune system damage following critical illness ...
(Date:7/9/2014)... 100 diseases that can attack soybean crops, why would ... wanted list? University of Illinois scientists cite the earth,s ... needed on the fungus that causes charcoal rot. , ... conditions but Macrophomina phaseolina , the fungus that ... , "As the climate continues to change and we ...
Breaking Biology News(10 mins):Biologists link sexual selection and placenta formation 2Biologists link sexual selection and placenta formation 3Biologists link sexual selection and placenta formation 4Immune function predicts infection risk among child trauma patients 2Immune function predicts infection risk among child trauma patients 3Climate change provides good growing conditions for charcoal rot in soybeans 2Climate change provides good growing conditions for charcoal rot in soybeans 3
... of proteins and other chemicals that underlies most ... molecules that accelerate chemical reactions between molecules. The ... the synthesis of chemicals and pharmaceuticals, devise new ... therapies. In the August 16 issue of ...
... has journeyed to this section of Antarcticas Amundsen Sea, but ... researchers and a Boerne High School science teacher will join ... sail on a two month expedition. The trip, ... to UTSA, is designed to study the relationship of sea ...
... evidence reported in the August issue of Cell Stem Cell, ... how the HIV/AIDS virus leads to learning and memory deficits, ... the surface of the virus not only kills some mature ... prevents the birth of new brain cells by crippling adult ...
Cached Biology News:MGH researchers describe new way to identify, evolve novel enzymes 2Texas researchers and educators head for Antarctica 2HIV is a 'double hit' to the brain 2
(Date:1/15/2014)... 15, 2014 More than 5 million ... 1 in 3 seniors will die with Alzheimer’s or ... jaw-dropping figures have shocked many Americans into looking for ... prevent these tragic age-related cognitive disorders. Jonathan Weisman, president ...
(Date:1/15/2014)... January 15, 2014 The Microcompetition with Foreign ... disease. One of these latent viruses is the Epstein Barr ... (RA). Rheumatoid arthritis (RA) is a chronic inflammatory disease that ... study found that RA patients have high concentrations of EBV ...
(Date:1/15/2014)... 2013 was a banner year of continued innovation ... continued independent research led by the team at Wake ... million grant from the Susanne Marcus Collins Foundation, had ... reviewed journal, Amy Grant highlighted Brainwave Optimization® in First ...
(Date:1/15/2014)... ON (PRWEB) January 15, 2014 AudioNotch ... experimental new therapy for the treatment of tinnitus. Patients ... tinnitus frequency, and over a period of weeks to months, ... Sound Therapy in two forms: Notched Music and Notched White ...
Breaking Biology Technology:Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... lend materials new characteristics are generally complicated and therefore ... to astonishment when scientists report on new methods which ... they use economically priced starting materials but also do ... framework made of polystyrene This is exactly ...
... BioSpace added Kansas to its annual promotional campaign of biotechnological, ... , , ... , , (Logo:   ... The leading employment Web site for the ...
... , July 29 Omeros Corporation (Nasdaq: ... equity financing facility under which it may sell up to ... to Azimuth Opportunity, Ltd. (the "investor") over a 24-month period. ... free to enter into and consummate other equity, debt and ...
Cached Biology Technology:Empa grows 'sea urchin'-shaped structures 2BioSpace Showcases the Midwest's Growing Life Science Region 2BioSpace Showcases the Midwest's Growing Life Science Region 3Omeros Secures $40 Million Committed Equity Financing Facility 2Omeros Secures $40 Million Committed Equity Financing Facility 3Omeros Secures $40 Million Committed Equity Financing Facility 4
The Econo gradient pump rack is a preassembled rack that is used to hold the components of the Econo gradient pump kits....
... with SR-101 Labeled Substrates (red fluorescence; ... measure serine protease activation • No ... FLISP Kits utilize cell-permeable, fluorescently labeled ... measure chymotrypsin-like activity in whole living ...
... Spacer Leu DAP FLISP Assay ... nm, Em=530 nm) • Accurately measure ... fixing, or permeabilization • B-Bridge's FLISP ... of serine proteases (FLISPs) to measure ...
... Spacer Leu-CMK FLISP Assay with FAM-Labeled ... nm) • Accurately measure serine protease ... permeabilization • B-Bridge's FLISP Kits utilize ... proteases (FLISPs) to measure chymotrypsin-like activity ...
Biology Products: