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GUMC and Oak Ridge National Labs announce unique research partnership
Date:10/23/2008

om Mason, PhD.

GUMC is a biomedical research and educational institution with an overall budget of $225 million; GUMC researchers brought in nearly $140 million in sponsored research funding last year. The academic medical center is home to one of only 41 comprehensive cancer centers in the country and the only one in the Washington area: Lombardi Comprehensive Cancer Center.

Several funded projects are already underway among GUMC and ORNL researchers in the areas of cancer and physiology. These include:

A project with Stephen Byers, PhD, professor of oncology at GUMC, and Gary Van Berkel, PhD, ORNL, designed to develop ways to enhance the measurement of bio-molecules that can be used to facilitate cancer diagnosis. Along with ORNL computing capabilities, the researchers are using atmospheric pressure surface sampling and ionization methods in conjunction with mass spectrometry detection to probe paraffin-embedded tissue to map biomarker metabolites in tumor tissue samples. Since many of these tissue samples are linked to clinical records, repositories of these samples contain a vast collection of pathological and potentially molecular data which can be retrospectively analyzed and linked to patient outcome.

A project with Brynn Voy, PhD, ORNL, and Zofia Zukowska, MD, PhD, chair of the department of physiology and biophysics at GUMC, which is further defining the interface between genetic susceptibility to stress and obesity using a systems genetics framework. The overarching goal of the project is to determine genetic and mechanistic interactions between adverse responses to stress and risk for obesity. Genotype data are integrated with physiological, biochemical and molecular stress response phenotypes to identify components of the stress-obesity interface that are sensitive to genetic variation and thus represent potential personalized therapeutic targets for disease intervention.

A project with Ram Datar, PhD, ORNL,
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Contact: Laura Cavender
lsc6@georgetown.edu
202-687-5100
Georgetown University Medical Center
Source:Eurekalert

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