Navigation Links
GOLFIG increased progression-free survival in colorectal cancer patients
Date:4/6/2011

ORLANDO, Fla. Oncologists can use colorectal cancer patients' own immune system to boost the effects of chemotherapy and increase progression-free survival, according to Phase III study results presented at the AACR 102nd Annual Meeting 2011, held here April 2-6.

Patients with advanced colorectal cancer are typically treated with combination chemotherapy with fluorouracil or the derivative product, capecitabine with or without levofolinic acid with irinotecan (FOLFIRI) or oxaliplatin (FOLFOX) given alone, or with the monoclonal antibodies bevacizumab, cetuximab or panitumumab.

"These combinations have been successful in inducing tumor regression, retarding disease progression and increasing overall survival. However, the average progression-free survival and overall survival are still no more than eight to 10 months and 20 to 22 months, respectively," said Pierpaolo Correale, M.D., Ph.D., an oncologist at the Siena University School of Medicine in Italy.

This study was started in 2005, before monoclonal antibodies were routinely used. Correale and colleagues added gemcitabine to FOLFOX followed by granulocyte-macrophage colony stimulating factor and low-dose aldesleukine (GOLFIG) to boost the immune system in an effort to fight cancer.

The researchers randomized 130 patients to receive GOLFIG or FOLFOX for a maximum of 12 cycles and then receive maintenance treatment until disease progression. The study was designed to follow the patients in both arms until death, but was ended early due to significantly better results seen with the GOLFIG regimen.

So far, the patients who received GOLFIG had a progression-free survival of 16.5 months compared with the 7.5 months recorded in those patients who received FOLFOX.

"Based on our experience and results to date, we believe that the GOLFIG regimen is superior to FOLFOX chemotherapy in terms of efficacy and comparable in terms of toxicity and cost," said Correa
'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Mayo: Variants in gene on X chromosome associated with increased susceptibility to Alzheimers
2. Reproductive life of male mice is increased by living with females
3. Swimmers at public beaches show increased risk of exposure to contagious staph bacteria
4. How increased UV exposure impacts plants
5. Mothers of multiple births at increased odds of postpartum depression
6. Vitamin D deficiency related to increased inflammation in healthy women
7. Purple sweet potato means increased amount of anti-cancer components
8. Severe breathing disorders during sleep are associated with an increased risk of dying
9. Increased climate volatility expected to worsen poverty vulnerability in developing countries
10. Insufficient levels of vitamin D puts elderly at increased risk of dying from heart disease
11. Global warming may spur increased growth in Pacific Northwest forests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... For AWI geologist Juliane Mller the Fram Strait is a ... side of this passage between Greenland and Svalbard warm Atlantic ... on the west side cold Arctic water masses and sea ... North Atlantic. A considerable portion of the Atlantic water cools ... deeper layers. The circulation of the water caused in this ...
(Date:8/21/2014)... RUSTON, La. A team of researchers ... innovative method for using affordable, consumer-grade 3D ... implants that can contain antibacterial and chemotherapeutic ... team comprised of doctoral students and research ... nanosystems engineering programs collaborated to create filament ...
(Date:8/20/2014)... study of 158 pregnant teenagers in Rochester, NY, nearly ... consumption of ice, cornstarch, vacuum dust, baby powder and ... study. , Moreover, such teens had significantly lower iron ... nonfood substances. , Pregnant teens, regardless of pica, are ... to iron deficiency and anemia. Low iron in pregnant ...
Breaking Biology News(10 mins):Arctic sea ice influenced force of the Gulf Stream 2Arctic sea ice influenced force of the Gulf Stream 3Louisiana Tech University researchers use 3D printers to create custom medical implants 2Louisiana Tech University researchers use 3D printers to create custom medical implants 3Pica in pregnant teens linked to low iron 2
... 17th, 2011, Shenzhen, China The South China Center ... world,s largest genomic organization, announced that they were among ... an international research group that completed the genome sequence ... Chinese rhesus macaque and cynomolgus. The study is published ...
... (UC Santa Barbara) Making waves as the ... a single layer of Carbon atoms has nonetheless ... be practical for innovative electronics applications. Researchers at UC ... quality graphene in a controlled manner that may pave ...
... 2011-- In a paper published today in Diabetologia , ... PhD, has identified the enzyme AMP kinase (AMPK) as key to ... defects such as spina bifida and some heart defects among babies ... diabetes -- either type 1 or type 2 -- work vigilantly ...
Cached Biology News:Genomic sequence and comparison of 2 macaques reveal new insights into biomedical research 2Genomic sequence and comparison of 2 macaques reveal new insights into biomedical research 3Genomic sequence and comparison of 2 macaques reveal new insights into biomedical research 4New method of growing high-quality graphene promising for next-gen technology 2New method of growing high-quality graphene promising for next-gen technology 3Joslin study finds clue to birth defects in babies of mothers with diabetes 2
(Date:8/21/2014)... 2014 SoundConnect , a ... as one of the nation’s Fastest Growing Private ... the 2nd consecutive year. Inc. magazine today ranked ... 500|5000, an exclusive ranking of the nation's fastest-growing ... look at the most important segment of the ...
(Date:8/20/2014)... often have it that American Indians largely were wiped ... influenza and tuberculosis brought to the New World by ... 20 million people lived in the Americas shortly before ... killed by European diseases., But new research led by ... Johannes Krause of the University of Tubingen in Germany ...
(Date:8/20/2014)... Group finds that the vascular access device market in ... and China (BRIC) was valued ... of the United States market that year. ... as a result of strong economic expansion, improving access to healthcare ... Resources Group,s coverage of the BRIC vascular access device market: ...
(Date:8/20/2014)... 20, 2014 /PRNewswire-iReach/ -- A case study from ... the school,s bioengineering department and the Intel® Internet ... Software Academic Program, UCSD,s research focuses on exploring ... body.  Photo - http://photos.prnewswire.com/prnh/20140819/137540 ... work of Dr. Todd P. Coleman , ...
Breaking Biology Technology:SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 3Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 2BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 3Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2
... (OTCBB: GNLK.OB, "the Company," or "GeneLink"), a ... the quarter ended September 30th, 2011. Bernard ... a business development potential, the third quarter has been ... Company.  The Company continues to make progress towards the ...
... New Report Added in ResearchMoz Reports Database - Ophthalmic ... Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market ... . GBI Researchs report, Ophthalmic ... Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic ...
... Phase I Single Dose Study Data Demonstrate Ideal ... Convergence Pharmaceuticals Limited ("Convergence"), the company focused on the ... announces that the multiple ascending dose Phase I study ... CNV2197944, for the treatment of chronic pain has been ...
Cached Biology Technology:GeneLink Marketing Efforts Poised to Show Results 2GeneLink Marketing Efforts Poised to Show Results 3ResearchMoz: Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market 2ResearchMoz: Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market 3ResearchMoz: Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market 4Convergence Pharmaceuticals Initiates Phase I Multiple Ascending Dose Study for CNV2197944 2Convergence Pharmaceuticals Initiates Phase I Multiple Ascending Dose Study for CNV2197944 3Convergence Pharmaceuticals Initiates Phase I Multiple Ascending Dose Study for CNV2197944 4
Antibody specific for trimethyl-Lys27 of histone H3. Mouse monoclonal. Antigen: Synthetic peptide derived from histone H3, trimethylated at lysine 27...
DL-Dithiothreitol (Clelands Reagent) ,PROTEASE FREE!! ,Molecular Biology Grade ,PRODUCT MUST SHIP NEXT DAY DURING HOT SUMMER MONTHS. ,C 4 H 10 O 2 S 2 ,Molecular Weight: 154.25 ,CAS RN: [27565-...
DTT 50 l...
...
Biology Products: