Navigation Links
GEN reports on strategies to overcome blood-brain barrier
Date:2/5/2009

New Rochelle, NY, February 5, 2009The blood-brain barrier (BBB) remains a major obstacle to the successful delivery of drugs to treat central nervous system (CNS) disorders, reports Genetic Engineering and Biotechnology News (GEN). Researchers are exploring a variety of approaches to preserve the ability of the BBB to block harmful and toxic substances from entering the brain and to permit the passage of effective medicines for the treatment of CNS diseases, according to the February 1 issue of GEN (http://www.genengnews.com/articles/chitem.aspx?aid=2778).

"The blood-brain barrier issue probably serves as the most significant roadblock to the treatment of central nervous system diseases," says John Sterling, Editor in Chief of GEN. "The key challenge is to treat people suffering from CNS disorders while trying to stay true to the physician's oath, 'First do no harm'."

One technology for enabling active transport of small molecule drugs across the BBB involves targeting endogenous nutrient transporters. These transporters are members of the solute carrier (SLC) transporter superfamily. Transport of small molecules across the BBB by these membrane proteins is known as carrier-mediated transport (CMT).

In order to design drugs that utilize CMT to cross the BBB, researchers modify their chemical structures so that they resemble nutrients that are transported across the BBB by specific SLCs. The prototypical drug that uses this strategy (which was developed long before mechanisms of CMT were known) is L-DOPA, the major current drug for Parkinson's disease. L-DOPA is used to replace dopamine that is lost due to degeneration of dopaminergic neurons in the substantia nigra of the brain.

Another major system that is used in normal mammalian physiology to enable needed molecules to cross the BBB is receptor-mediated transport (RMT). The b
'/>"/>

Contact: John Sterling
jsterling@genengnews.com
914-740-2196
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert

Page: 1 2

Related biology news :

1. GEN reports on growing reliance on microfluidics technology
2. Cytori reports benefit of adipose-derived regenerative cells in spinal disc model
3. GEN reports growing focus on PI3-kinase pathway in cancer research
4. Genetic Engineering & Biotechnology News reports on the trend toward predictive toxicogenomics
5. Orchid Cellmark Reports Third Quarter 2008 Financial Results
6. Communication Intelligence Corporation Reports Third Quarter 2008 Financial Results
7. Synaptics Reports Record Results for First Quarter of Fiscal 2009
8. GEN reports on novel tools for deciphering biological networks
9. Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
10. LSUHSC research reports new method to protect brain cells from diseases like Alzheimers
11. Communication Intelligence Corporation Reports Second Quarter 2008 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2015)... According to a new ... Area), Technology, Material (Optical Prism, Piezoelectric, Capacitive & ... Others) & Geography - Global Forecast to 2014 ... is expected to reach $14,500.07 Million by 2020, ... Browse 76 market Tables and 109 Figures spread ...
(Date:6/24/2015)... 24, 2015 The biologics safety testing market ... for the market include growth of the pharmaceutical and ... launches. Over the years, the number of drug approvals ... 2010, the FDA approved 225 drug applications and Health ... Europe accounted for 3,822 of the ...
(Date:6/24/2015)... DUBLIN , June 22, 2015 ... has announced the addition of the "Huawei ... Analysis" report to their offering. ... going to the opposite direction than Apple,s and ... innovative fingerprint sensor developed by Fingerprint Cards, a ...
Breaking Biology News(10 mins):Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2
... and Research Center report in the March issue of ... as fibulins 3 and 5, slow the growth of ... sprouting. The proteins are promising candidates for use in ... which regulate cell proliferation, migration and invasion. In the ...
... imaging study shows that age-related breakdown of myelin, the ... with the presence of a key genetic risk factor ... the January edition of the peer-reviewed journal Archives of ... evidence that myelin breakdown is a key contributor to ...
... home, but the presence of gas stresses out plants too. ... University of Nottingham have found that changes in the physical ... leaks in natural gas pipelines. "Our study was about ... leaks via the spectrum of reflected light from plants, which ...
Cached Biology News:Proteins stop blood-vessel and tumor growth in mice 2Imaging study links key genetic risk for Alzheimer's disease to myelin breakdown 2Plants used to detect gas leaks, from outer space! 2
(Date:7/30/2015)... France and Dallas, TX, USA (PRWEB) , ... ... ... of innovative nano and microsystems, has appointed Francois Vieillard as Sales & Marketing ... Marketing at executive positions, Francois Vieillard will be responsible for reinforcing Tronics’ business ...
(Date:7/30/2015)... San Diego , CA (PRWEB) , ... July ... ... Biopharma, announced the successful completion of a field clinical study of its canine ... being developed together with Aratana Therapeutics (Kansas City, KS) and will be marketed ...
(Date:7/30/2015)... July 30, 2015  With over 60,000 customers across the globe, ISN improves the ... hiring organizations with more than 60,000 safe and reliable contractors in over 80 countries. ... ... Over 60,000 ... Headquartered in Dallas, TX , ...
(Date:7/30/2015)...  Discovery Laboratories, Inc. (Nasdaq: DSCO ) ... $1.0M tranche under a previously awarded Phase II ... up to $3.0 million to support continued development ... potential medical countermeasure to mitigate acute and chronic/late-phase ... initial $1.0 million under this grant in October ...
Breaking Biology Technology:Tronics appoints Francois Vieillard as Sales and Marketing Director 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3
... week from his position as director of the nonpartisan ... on the reasons for his ouster. , ,And while ... results of an audit of the bureaus performance as ... Speaker John Gard (R-Peshtigo) said the move was simple ...
... WI. - A business Internet Service Provider (ISP) in ... getting ready to launch a virus protection service ... FirstBridge, McAfee and Postini. , , Cyberlynk Network Inc. ... to add virus protection to the service offering in ...
... , ,MADISON-WI. - The Wisconsin Technology Network recently ... researcher about his work in games and education, and ... used in academics. , ,Kurt Squire, Ph.D., was ... his research on games and learning. A former elementary ...
Cached Biology Technology:Wahl Mute on Firing from Legislative IT Bureau -- but politics could be to blame 2Franklin Firm to Pick Fight with Postini? 2Franklin Firm to Pick Fight with Postini? 3Franklin Firm to Pick Fight with Postini? 4GameBased Learning Strategies 2GameBased Learning Strategies 3
Sequencing and primer design rolled into one. Just give us your clone and a reference sequence, and we'll do the rest. Single-strand or double-strand coverage. Guaranteed results....
... Rabbit polyclonal antibody to human XAB2 (amino ... first identified through its interaction with XPA. ... fraction of XAB2 interacts with the transcription-coupled ... as with RNA polymerase II. Microinjection experiments ...
... coating using advanced automated high throughput microplate processing equipment that ... also accommodate virtually any lot size of the following formats ... 8 and 12 well strips, ... 384 well microplate, ...
...
Biology Products: