Navigation Links
GEN reports on expanding NextGen sequencing applications
Date:9/3/2009

New Rochelle, NY, September 3, 2009Next-Generation Sequencing (NGS) technologies are not only beginning to supplant traditional Sanger sequencing methodology but are also giving DNA microarrays a run for the money as well, reports Genetic Engineering & Biotechnology News (GEN). Advantages of NGS include a streamlined workflow that eliminates transformation and colony picking and massive parallelism, according to the September 1 issue of GEN (www.genengnews.com/articles/chitem.aspx?aid=3016).

"De novo and resequencing projects have boosted interest in NGS," says John Sterling, Editor in Chief of GEN. "Other drivers include amplicon, transcriptome, and metagenomics research."

Jin Billy Li, Ph.D., from the Church Laboratory at Harvard Medical School, uses Illumina's Solexa sequencing system to do targeted sequencing of RNA editing sites. Targeted sequencing is an increasingly popular practice to further reduce the costs associated with sequencing. Rather than sequencing a whole genome or a whole library, targeted pieces are selected based on the nature of the study.

Matthew Ferber, Ph.D., codirector of the clinical molecular genetics laboratory at Mayo Clinic, is working on hereditary colon cancer. His team starts with 22 colon cancer genes on a Roche NimbleGen capture array, then elutes the DNA and submits it for second-generation sequencing on the 454 Life Sciences and Solexa platforms.

Nicholas Bergman, Ph.D., assistant professor in the school of biology at Georgia Institute of Technology, studies bacterial gene expression. He utilizes the Solexa platform and the SOLiD system from Applied Biosystems, a part of Life Technologies, to probe the functions and relationships of the Bacillus anthracis transcriptome.

Broad Institute scientists are working on identifying genetic changes that may cause glioblastoma, such as point mutations, structural rearrangements, and other events in the genome. One of the key strategies of their approach is targeting only the coding portion of the genome, which is just 1𔃀% of the overall genome. They utilize a method invented at the institute and work in collaboration with Agilent.


'/>"/>

Contact: John Sterling
jsterling@genengnews.com
914-740-2196
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert

Related biology news :

1. BIO-key Reports Second Quarter 2007 Results
2. Communication Intelligence Corporation Reports Second Quarter 2007 Financial Results
3. Emory paleontologist reports discovery of carnivorous dinosaur tracks in Australia
4. BIO-key Reports Third Quarter 2007 Results
5. WHRC releases 4 key reports
6. Rong Li Lab reports protein interactions of MAP kinase signaling pathway
7. UVA reports surprising findings related to myotonic muscular dystrophy
8. Drug aimed at 2 bioterror agents blocks live viral infection, Weill Cornell team reports
9. MIT reports new twist in microRNA biology
10. Aware, Inc. Reports Fourth Quarter and 2007 Financial Results
11. Genetic Engineering & Biotechnology News reports on advances in miRNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2017)... SINGAPORE , May 5, 2017 ... has just announced a new breakthrough in biometric ... that exploits quantum mechanical properties to perform ... new smart semiconductor material created by Ram Group ... across finance, entertainment, transportation, supply chains and security. ...
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. ... company, announces the filing of its 2016 Annual Report on Form ... Exchange Commission. ... Form 10-K is available in the Investor Relations section of the ... on the SEC,s website at http://www.sec.gov . 2016 ...
(Date:4/11/2017)... Research and Markets has announced the addition ... their offering. ... tracking market to grow at a CAGR of 30.37% during the ... 2017-2021, has been prepared based on an in-depth market analysis with ... its growth prospects over the coming years. The report also includes ...
Breaking Biology News(10 mins):
(Date:5/16/2017)... Switzerland (PRWEB) , ... May 16, 2017 , ... ... R&D, today announced its global Genedata Screener User Group Meetings, which ... Screener users the opportunity to share best practices in screening data analysis and ...
(Date:5/16/2017)... May 16, 2017 Telehealth has long ... and something that has been kept completely separate ... But according to   Logicalis Healthcare Solutions , ... IT solutions and managed services provider ( www.us.logicalis.com ... overlooked – interrelationship between telehealth, imaging, and EHR ...
(Date:5/15/2017)... ... May 15, 2017 , ... Catalent Pharma Solutions, the ... and consumer health products, today announced that it has signed an agreement with ... preclinical and clinical development of TA-46, a novel protein addressing achondroplasia, which is ...
(Date:5/12/2017)... ARBOR, Mich. , May 12, 2017 ... selected to present at the 36th annual Michigan Growth ... Forum. GreenMark, a Delaware corporation ... be presenting to investors in attendance, including more than ... deliver health benefits to society through biobased targeting technologies. ...
Breaking Biology Technology: