Navigation Links
GEN reports on expanding NextGen sequencing applications
Date:9/3/2009

New Rochelle, NY, September 3, 2009Next-Generation Sequencing (NGS) technologies are not only beginning to supplant traditional Sanger sequencing methodology but are also giving DNA microarrays a run for the money as well, reports Genetic Engineering & Biotechnology News (GEN). Advantages of NGS include a streamlined workflow that eliminates transformation and colony picking and massive parallelism, according to the September 1 issue of GEN (www.genengnews.com/articles/chitem.aspx?aid=3016).

"De novo and resequencing projects have boosted interest in NGS," says John Sterling, Editor in Chief of GEN. "Other drivers include amplicon, transcriptome, and metagenomics research."

Jin Billy Li, Ph.D., from the Church Laboratory at Harvard Medical School, uses Illumina's Solexa sequencing system to do targeted sequencing of RNA editing sites. Targeted sequencing is an increasingly popular practice to further reduce the costs associated with sequencing. Rather than sequencing a whole genome or a whole library, targeted pieces are selected based on the nature of the study.

Matthew Ferber, Ph.D., codirector of the clinical molecular genetics laboratory at Mayo Clinic, is working on hereditary colon cancer. His team starts with 22 colon cancer genes on a Roche NimbleGen capture array, then elutes the DNA and submits it for second-generation sequencing on the 454 Life Sciences and Solexa platforms.

Nicholas Bergman, Ph.D., assistant professor in the school of biology at Georgia Institute of Technology, studies bacterial gene expression. He utilizes the Solexa platform and the SOLiD system from Applied Biosystems, a part of Life Technologies, to probe the functions and relationships of the Bacillus anthracis transcriptome.

Broad Institute scientists are working on identifying genetic changes that may cause glioblastoma, such as point mutations, structural rearrangements, and other events in the genome. One of the key strategies of their approach is targeting only the coding portion of the genome, which is just 1𔃀% of the overall genome. They utilize a method invented at the institute and work in collaboration with Agilent.


'/>"/>

Contact: John Sterling
jsterling@genengnews.com
914-740-2196
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert

Related biology news :

1. BIO-key Reports Second Quarter 2007 Results
2. Communication Intelligence Corporation Reports Second Quarter 2007 Financial Results
3. Emory paleontologist reports discovery of carnivorous dinosaur tracks in Australia
4. BIO-key Reports Third Quarter 2007 Results
5. WHRC releases 4 key reports
6. Rong Li Lab reports protein interactions of MAP kinase signaling pathway
7. UVA reports surprising findings related to myotonic muscular dystrophy
8. Drug aimed at 2 bioterror agents blocks live viral infection, Weill Cornell team reports
9. MIT reports new twist in microRNA biology
10. Aware, Inc. Reports Fourth Quarter and 2007 Financial Results
11. Genetic Engineering & Biotechnology News reports on advances in miRNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... , June 27, 2016 Research and ... North America 2016-2020" report to their offering. ... North America to grow at a CAGR of ... been prepared based on an in-depth market analysis with inputs from ... prospects over the coming years. The report also includes a discussion ...
(Date:6/22/2016)... -- The American College of Medical Genetics and Genomics was once ... one of the fastest-growing trade shows during the Fastest 50 ... Las Vegas . Winners ... each of the following categories: net square feet of paid ... The 2015 ACMG Annual Meeting was ranked 23 out of ...
(Date:6/22/2016)... LOS ANGELES , June 22, 2016 ... of identity management and verification solutions, has ... cutting edge software solutions for Visitor Management, ... ® provides products that add functional ... The partnership provides corporations and venues with ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... LOUISVILLE, Ky. , June 23, 2016 /PRNewswire/ ... from two Phase 1 clinical trials of its ... double-blind, placebo-controlled, single and multiple ascending dose studies ... and pharmacodynamics (PD) of subcutaneous injection in healthy ... APL-2 subcutaneously (SC) either as a single dose ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... & Hematology Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 ... Review , the peer-reviewed journal from touchONCOLOGY, ... the escalating cost of cancer care is placing ... a result of expensive biologic therapies. With the ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... is exhibiting at the Pennsylvania Convention Center and will showcase its product’s latest ... ClinCapture will also be presenting a scientific poster on Disrupting Clinical Trials in ...
(Date:6/23/2016)... Connecticut (PRWEB) , ... June 23, 2016 , ... ... introduce a new line of intelligent tools designed, tuned and optimized exclusively for ... September 12–17 in Chicago. The result of a collaboration among several companies with ...
Breaking Biology Technology: