Navigation Links
GE Healthcare studies report results of [18F]Flutemetamol research
Date:7/20/2011

Chalfont St. Giles, UK, July 20, 2011 - Recent clinical research data reported that the investigational amyloid imaging agent [18F]Flutemetamol showed highly consistent image interpretation1 and showed comparable in vitro binding to the Pittsburgh Compound-B ([C-11]PiB)) investigational imaging agent3. Flutemetamol is a GE Healthcare Positron Emission Tomography (PET) investigational imaging agent currently in phase III development being studied for the detection of beta amyloid using PET brain scans.

The buildup of beta amyloid in the brain can lead to the degeneration of neurons and is one of several markers implicated in the development of AD. Currently, AD is typically confirmed by identifying the presence of tissue markers, including beta amyloid plaques, in post-mortem brain samples. Use of targeted imaging agents may help physicians detect amyloid deposition in live humans.

"These results should provide encouragement for patients and clinicians about the value of amyloid imaging in diagnosing AD," said Jonathan Allis, MI PET Segment Leader, GE Healthcare Medical Diagnostics. "Use of PET imaging scans to detect AD pathology may enable physicians to make a more accurate and earlier diagnosis of the disease."

Data highlights from three clinical abstracts to be featured at the 2011 Alzheimer's Association International Conference on Alzheimer's Disease (ICAD) in Paris suggest that:

  • Flutemetamol reader training provided a highly consistent method for interpreting PET images. Readers blinded to clinical information demonstrated high inter- and intra-reader agreement rates when interpreting the brain distribution of Flutemetamol as normal and abnormal images.
  • Flutemetamol imaging was consistent with the understanding that normal pressure hydrocephalus (NPH), a progressive condition associated with dementia, gait abnormalities and urinary incontinence, represents a heterogeneous population with evidence of AD pathology.
  • 6-CN-Flutemetamol is comparable to 6-CN-Pittsburgh Compound-B (PiB) in its ability to bind to beta amyloid in vitro.

"At GE Healthcare, we are fully committed to developing products and tools that enable physicians to make confident medical decisions, allowing patients to get accurate diagnosis earlier in the process," said Pascale Witz, CEO, GE Healthcare Medical Diagnostics.

[18F]Flutemetamol is one part of a broad portfolio of diagnostic solutions that GE Healthcare is currently developing in the Alzheimer's field. The company is taking a comprehensive approach to understanding AD through its ongoing research to uncover the causes, risks and physical effects of the disease. GE Healthcare's global commitment to advance clinical knowledge and provide a variety of technologies to aid the fight in this epidemic may assist physicians in the acceleration of diagnosis and improvement of treatment decisions in all stages of the disease. The company already offers a range of imaging modalities used by physicians to assist in the detection of AD and dementia (CT, MRI, PET, SPECT) and has been a key contributor to the Alzheimer's Disease Neuroimaging Initiative since its inception. GE Healthcare also plays a key role in PredictAD, an EU-funded research project to develop solutions to enable earlier diagnosis of AD.


'/>"/>

Contact: Aleisia Gibson
Aleisia.gibson@ge.com
609-865-4004
Edelman Public Relations
Source:Eurekalert

Related biology news :

1. TGen, Scottsdale Healthcare, Mayo Clinic study new drug to stimulate immune system of cancer victims
2. Phoenix conference highlights TGens and Scottsdale Healthcares contributions to molecular oncology
3. TGen Clinical Research Services at Scottsdale Healthcare and Mayo Clinic study new cancer drug
4. TGen-Scottsdale Healthcare researchers make breakthrough in lung cancer
5. GE Healthcare President & CEO, Mark Vachon, to Present at BioConference Live
6. GE Healthcare to evaluate and develop novel imaging technology
7. Scott & White Healthcare researcher finds success with new anti-cancer drug
8. Scott & White Healthcare researcher finds success with new anti-cancer drug
9. The Full Yield, Inc. Launches Breakthrough Collaboration to Put Food Back at the Heart of Healthcare
10. Inventor honored for tech improving access to clean water, healthcare, and business development in India
11. Lexicon to Present Clinical Data for Diabetes Drug Candidate, LX4211, at Two Major Healthcare Conferences
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... , April 28, 2016 First quarter 2016: ... up 966% compared with the first quarter of 2015 ... SEK 589.1 M (loss: 18.8) and the operating margin was 40% ... 0.32) Cash flow from operations was SEK 249.9 M ... revenue guidance is unchanged, SEK 7,000-8,500 M. The operating ...
(Date:4/15/2016)... CHICAGO , April 15, 2016  A ... companies make more accurate underwriting decisions in a ... offering timely, competitively priced and high-value life insurance ... health screenings. With Force Diagnostics, rapid ... and lifestyle data readings (blood pressure, weight, pulse, ...
(Date:3/31/2016)...   LegacyXChange, Inc. ... LegacyXChange is excited to release its first ... be launched online site for trading 100% guaranteed authentic ... also provide potential shareholders a sense of the value ... industry that is notorious for fraud. The video is ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016 Andrew D ... http://doi.org/10.17925/OHR.2016.12.01.22 Published recently in ... from touchONCOLOGY, Andrew D Zelenetz , discusses ... care is placing an increasing burden on healthcare ... therapies. With the patents on many biologics expiring, ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... a new line of intelligent tools designed, tuned and optimized exclusively for Okuma ... 12–17 in Chicago. The result of a collaboration among several companies with expertise ...
(Date:6/22/2016)... June 22, 2016 Research and Markets has ... report to their offering. ... 2014 from $29.3 billion in 2013. The market is expected to ... from 2015 to 2020, increasing from $50.6 billion in 2015 to ... forecasts during the forecast period (2015 to 2020) are discussed. As ...
(Date:6/22/2016)... 2016   ViaCyte, Inc. , a privately-held regenerative ... replacement therapy for the treatment of diabetes in clinical-stage ... Meeting.  ISSCR 2016, the Global Stem Cell Event, is ... in San Francisco.    ... follows:Event: , Focus Session: Tools for Basic and Applied ...
Breaking Biology Technology: