Navigation Links
GARP makes the difference
Date:6/15/2009

Scientists from the Helmholtz Center for Infection Research in Braunschweig, Germany and the Medical School Hannover, Germany have succeeded in treating immune cells in a way that enables them to inhibit unwanted immune reactions such as organ rejection. Their results have now been published in the current issue of the scientific journal Journal of Cellular and Molecular Medicine.

The immune system keeps us healthy: day and night it protects us against invading and harmful pathogens. But this fulltime surveillance can also turn into a problem, for example after an organ transplant. The immune system recognizes the new organ as "foreign" and starts fighting it. In the end, the life-saving transplant will be rejected. Until now, only special drugs have managed to keep the immune system silent and thus inhibit organ rejection.

Theoretically, these drugs are not necessary because the immune system has its own unique "peace makers": regulatory T cells (Tregs), a special group of helper T cells, an important cell type of the immune system. Tregs inhibit immune reactions and are thus of special medical interest. Until now, distinguishing between Tregs and helper T cells has represented a problem for scientists. Now, in co-operation with the Medical School Hannover, researchers from the Helmholtz Centre for Infection Research in Braunschweig have identified a molecular factor that plays an essential role in Treg function. This protein constitutes the key difference between Tregs and helper T cells. Furthermore, the scientists have also generated Tregs from helper T cells that permanently maintained their characteristics.

The key to Tregs is called "GARP". Michael Probst-Kepper is a researcher in a junior research group that is financed by the German Volkswagen foundation, he works at both HZI and MHH. He has now deciphered the special role of the GARP protein. Until now, scientists had only little distinguishing features to aid them in
'/>"/>

Contact: Dr. Bastian Dornbach
bastian.dornbach@helmholtz-hzi.de
49-531-618-11407
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. New drug makes weight loss safer
2. How mother of thousands makes plantlets
3. For honey bee queens, multiple mating makes a difference
4. Scientists spy enzyme that makes us unique
5. Thinking makes it so: Science extends reach of prosthetic arms
6. Choosing dry or wet food for cats makes little difference
7. Technique controls nanoparticle size, makes large numbers
8. Decoy makes sitting duck of superbugs
9. Case researcher in RNA biology makes waves by challenging current thinking
10. New process makes nanofibers in complex shapes and unlimited lengths
11. Diabetes makes it hard for blood vessels to relax
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... Research Careers) Program has announced the travel award recipients ... 18 22, 2014 in San Diego, California. ... students, post doctorates and scientists from underrepresented groups into ... encourage the participation of young scientists at the American ... 16 awards totaling $29,600., The FASEB MARC Program is ...
(Date:8/28/2014)... The support of peer groups and clinicians ... programs, according to recent University of Georgia research. ... the Athens-Clarke County area determined that role models ... of mothers of infants. , "Mothers who received ... at breastfeeding," said study co-author Alex Anderson, an ...
(Date:8/28/2014)... FASEB MARC (Maximizing Access to Research Careers) ... the American College of Sports Medicine,s Conference on ... in Miami, Florida. These awards are meant ... and scientists from underrepresented groups into the mainstream ... the participation of young scientists at the American ...
Breaking Biology News(10 mins):Breastfeeding study shows need for effective peer counseling programs 2
... Durham, NC The most toxic, brightly colored members of ... says a new study. So-named because some tribes use ... frogs of the Amazon jungle are well known for their ... forest frogs serve to broadcast their built-in chemical weapons: ...
... project to develop and evaluate new tools to control ... a five year, 12 million project involving sixteen partners ... Seventh Framework programme. Because malaria is transmitted by ... disease. Wide scale use of insecticides on bednets ...
... laboratory discoveries into daily clinical practice is important, but ... to the laboratory, to further explore and explain clinically ... basic researchers to understand and address clinical challenges and ... integrate and use new technologies. The key towards ...
Cached Biology News:Fitness tests for frogs? 2€12 million ($16.9 million) project to develop new tools for malaria control 2
(Date:8/28/2014)... , Aug. 28, 2014  Next month, executives from ... three key industry events beginning with Patient-Centered Clinical Trials ... in Boston , September 4-5. Patient recruitment ... and Aaron Fleishman will share insights on the ... a variety of tactics – from media to mobile apps ...
(Date:8/28/2014)... new work by a Florida State University research team ... take your temperature, emit white light, and convert photon ... looks like a butterfly. , Biwu Ma, associate professor ... the FAMU-FSU College of Engineering, created the molecule in ... to discover that his creation has many other unique ...
(Date:8/28/2014)... PrimeSource Building Products, Inc., a leading ... to support their communication needs with the ... conferencing platform GlobalMeet powered by SoundConnect. The solution ... SoundConnect delivers award winning “results driven” business class ... be utilizing GlobalMeet powered by SoundConnect ...
(Date:8/27/2014)... 2014 Green & Grow Inc. (GGI) ... funding and secured Otter Capital as a significant new ... commercialization of GGI’s Agriplier™ technology, building on recent compelling ... “Since our first meeting, we have been impressed with ... space,” said Alan Sobba, President and CEO of GGI. ...
Breaking Biology Technology:BBK Worldwide Leads Sessions at Key September Events 2Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2PrimeSource Chooses SoundConnect as Collaboration Provider 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3
... LINCOLN, Neb., Aug. 20 LI-COR announces its second,webinar ... in In Vivo Imaging: Near Infrared Optical Imaging of ... CDT., Near-infrared (NIR) fluorescence offers dramatic benefits for ... depth of penetration and,decreased autofluorescence and light scatter that ...
... 20 MedPredict, a global,provider of pharmaceutical competitive ... providing critical strategic insight for pharma,and biotech companies ... sclerosis,(MS) therapies., Biogen/Elan,s Tysabri has been under ... a rare and potentially fatal brain disease,associated with ...
... Joseph F. Finn, Jr.,C.P.A. ("Finn"), Assignee of the assets ... today that all pharmaceutical,intellectual property will be sold at ... of the pieces of intellectual property for sale is ... of a,branded drug that currently has more than $2 ...
Cached Biology Technology:LI-COR August 27th On-Line Webinar Introduces New Approach to Small Animal In Vivo Imaging 2Expert Neurology Panel Weighs Impact of New Reports of PML in Multiple Sclerosis Patients on Tysabri 2Spherics, Inc. Successful Bidder May Make MHRA Submission 2
Eppendorf tube holder, for Tube rack 175 x 12 mm, 100. Category: Chromatography Systems & Accessories, Systems....
... Alkaline Phosphatase, Calf Intestinal (CIAP), catalyzes ... RNA, and ribo- and deoxyribonucleoside triphosphates. This ... religation of linearized cloning vector DNA by ... may also be used for the dephosphorylation ...
Agarose, pulse field, 100 g. Nuclease-free.Gel point (1.5%): 36 1.5 C, EEO (-mr): 1800 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Molecular Biological Resources has extensive abilities cloning and expression of prokaryotic and eukaryotic proteins. Please contact lloconne@molbiores.com to discuss your project. Contact lloconne@...
Biology Products: