Navigation Links
G protein-coupled receptor mediates the action of castor oil
Date:5/21/2012

icinoleic acid on various cell cultures. Following this, the researchers at Bad Nauheim began a more detailed investigation. Hundreds of receptors were systematically turned off, and then the reaction of the cells to ricinoleic acid tested. Ultimately, they succeeded in identifying the key receptor with the name EP3.

"Experiments with mice in which the EP3 receptor had previously been specifically turned off by a genetic operation provided us with convincing proof", explains Sorin Tunaru. "Unlike their genetically unchanged fellow species, after being given castor oil or even just ricinoleic acid, the mice without the EP3 receptor exhibited no increased defecation." And in pregnant animals, no increased labour was found, which suggests that in both cases the EP3 receptor is responsible.

The Max Planck scientists concluded from this that after being released from the castor oil, the ricinoleic acid is first of all absorbed by the body via the intestinal mucosa; the EP3 receptor then becomes active on the muscle cells of the intestine and uterus, which in turn stimulates intestinal activity and labour.

In Stefan Offermanns' opinion, the light shed on the action mechanism of this old drug could lead to a reassessment of its clinical use. "Castor oil is still widely used in alternative and folk medicine. However, in conventional medicine it has been decreasingly propagated in the last few decades, not least because the action mechanism was unclear. The results of our study could be a factor in this changing again."

There is also the hope that for the synthetic active ingredients already used today new areas of application will open up. For example, today, substances are also used which we have identified for the ricinoleic acid that activate the responsible receptor to in-crease labour. It is conceivable that mild-action drugs could be developed from these substances to cleanse the intestine or promote intestinal activity. At any ra
'/>"/>

Contact: Professor Dr. Stefan Offermanns
stefan.offermanns@mpi-bn.mpg.de
49-603-270-51202
Max-Planck-Gesellschaft
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Measuring progesterone receptor expression to improve hormone-receptor-positive cancer management
2. Clinical guide on selective estrogen receptor modulators for postmenopausal osteoporosis
3. Body clock receptor linked to diabetes in new genetic study
4. Researchers identify possible receptor for key breast cancer regulator
5. Receptor for tasting fat identified in humans
6. Addex scientists discover GLP-1 induced interaction between GLP-1 and GIP receptors
7. Gene switch for odorant receptors
8. Novel technique switches triple-negative breast cancer cells to hormone-receptor positive cells
9. Rogue receptor opens door for rare kidney disease
10. Small molecule receptor detects lipids telltale sign of cell death
11. USC scientists generate first detailed map of human neuroreceptor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
G protein-coupled receptor mediates the action of castor oil
(Date:6/30/2015)... , June 30, 2015 To bolster its efforts ... HYPR Corp. announced today the addition of two new team ... as board advisor and David Raviv will act ... underscore HYPR Corp.,s commitment to providing the most secure solutions ... Sirota co-founded Layer 7 Technologies, a provider of security ...
(Date:6/30/2015)... Pa. , June 30, 2015 ... the company as CEO to help further develop Genisphere,s ... wealth of partnering experience, having spent much of the ... including Therakine, Amgen, Baxter Bioscience, and Johnson & Johnson. ... focus on Technology and Biotech Corporate Finance. He graduated ...
(Date:6/29/2015)... 24, 2015 Research and ... "Latin America Biomedical Sensors Market - Growth, Trends ... The Latin America Biomedical Sensors market is estimated ... 2.04% over the period 2014-2020 The near ... the genetic formulation of each individual. These sensors can ...
Breaking Biology News(10 mins):HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 3Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3Latin America Biomedical Sensors Market Report 2015-2020 2
... ARBOR, Mich. An early laboratory success is taking ... gland transplants that could one day prevent a currently ... The scientists were able to induce embryonic stem ... hormone essential to maintaining bone density. The laboratory results ...
... ANN ARBOR, Mich.---Brain implants that can more clearly record ... at the University of Michigan. The findings could eventually ... as Parkinson,s disease and paralysis. Neural electrodes must ... When the electrodes are implanted, the brain first reacts ...
... calling on Congress to support the Consistency, Accuracy, Responsibility ... (CARE bill), which would ensure that states set minimum ... bill (H.R. 3652) was introduced Sept. 28 in the ... "The introduction of the CARE bill ...
Cached Biology News:Stem cell success points to way to regenerate parathyroid glands 2A step toward better brain implants using conducting polymer nanotubes 2A step toward better brain implants using conducting polymer nanotubes 3SNM urges Congress to support CARE bill 2
(Date:6/30/2015)... ... June 30, 2015 , ... ... She has accepted the position of vice president of instruction at Chippewa Valley ... , “I greatly appreciated the opportunity to lead SIUE during the past three ...
(Date:6/29/2015)... ... June 29, 2015 , ... ... Under the terms of the agreement, MediVet will acquire the rights to a ... MB-007 is currently in pre-clinical development as a potential next-generation treatment for various ...
(Date:6/29/2015)...  Neuralstem, Inc. (NYSE MKT: CUR), a biopharmaceutical company ... and cell therapy treatments for central nervous system diseases, ... on the NASDAQ Capital Market under the symbol "CUR." ... the NYSE MKT until the market close on July ... expected to commence on July 13, 2015. ...
(Date:6/29/2015)... Elsevier , a world-leading ... services, today announced the highlights of its journal Impact ... Citation Reports® (JCR) published by Thomson Reuters, Elsevier saw ... to 2014, ahead of the aggregate across other journals. ... 62 subject categories, up from 61 in 2013. ...
Breaking Biology Technology:SIUE’s Furst-Bowe Accepts VP of Instruction at CVTC 2SIUE’s Furst-Bowe Accepts VP of Instruction at CVTC 3MediVet Biologics Acquires Exclusive Patent License from Kansas State University 2MediVet Biologics Acquires Exclusive Patent License from Kansas State University 3Neuralstem, Inc. Announces Approval for Listing on the NASDAQ Capital Market 2Neuralstem, Inc. Announces Approval for Listing on the NASDAQ Capital Market 3Elsevier Announces 2014 Citation Impact Highlights 2Elsevier Announces 2014 Citation Impact Highlights 3
... Multiporator / Electroporator 2510 , , , , , , , ... Protocol No. 4308 915.521 02/2002 , , , ... , Microorganism , ... Cell type , Bacteria, gram positive, , ...
... , , , , Multiporator / Electroporator 2510 , , , ... Transformation Protocol , Protocol No. 4308 915.514 04/2002 , ... , , , , ... , Cell type , Bacteria, ...
... , , , , Multiporator / Electroporator 2510 , , , ... Transformation Protocol , Protocol No. 4308 915.511 04/2002 , ... , , , , ... , Cell type , Bacteria, gram ...
Cached Biology Technology:Mycobacterium intracellulare 2Escherichia coli K12 2Escherichia coli K12 3Escherichia coli C600 2Escherichia coli C600 3
Mouse monoclonal antibody raised against a partial recombinant STAU2. NCBI Entrez Gene ID = STAU2...
...
Mouse polyclonal antibody to NR2F2 - nuclear receptor subfamily 2, group F, member 2...
... Pack provides optimized blocking and wash ... Clarifier: Ready-to-use wash solutions have been ... Coated Slides for Microarrays (Product Code ... Buffer: 1L • Microarray Post Hybridization ...
Biology Products: