Navigation Links
Fuzzy logic predicts cell aging
Date:6/17/2010

Philadelphia, PA The process of aging disturbs a broad range of cellular mechanisms in a complex fashion and is not well understood. Computer models using fuzzy logic might help to unravel these complexities and predict how aging progresses in cells and organisms, according to a study from Drexel University in Philadelphia and Children's Hospital Boston.

"One important goal of computational approaches in aging is to develop integrated models of a unifying aging theory in order to better understand the progression of aging phenotypes grounded on molecular mechanisms," said Andres Kriete, Associate Professor at Drexel's School of Biomedical Engineering, Science and Health Systems and lead author of the study.

The study, which will appear in the June issue of PLOS Computational Biology (http://www.ploscompbiol.org/doi/pcbi.1000820), relates progressive damage and dysfunction in aging, dubbed a vicious cycle, to inflammatory and metabolic stress response pathways. Interestingly, the activation of these pathways remodels the inner functioning of the cell in a protective and adaptive manner and thus extends lifespan.

This is the first time that scientists have applied fuzzy logic modeling to the field of aging. "Since cellular biodynamics in aging may be considered a complex control system, a fuzzy logic approach seems to be particularly suitable," said Dr. William Bosl, co-author of this study. Dr. Bosl, a staff scientist in the Informatics Program at Children's Hospital Boston, developed a fuzzy logic modeling platform called Bionet together with a cell biologist, Dr. Rong Li of the Stowers Institute for Medical Research in Kansas City, to study the complex interactions that occur in a cell's machinery using the kind of qualitative information gained from laboratory experiments.

Fuzzy logic can handle imprecise input, but makes precise decisions and has wide industrial applications from air conditioning to anti-lock break systems in cars, using predefined rules. In a similar fashion, the aging model relies on sets of rules drawn from experimental data to describe molecular interactions. "Integration of such data is the declared goal of systems biology, which enables simulation of the response of cells to signaling cues, cell cycling and cell death," said Glenn Booker, who is Faculty at the College of Information Science and Technology at Drexel and co-author on the study.

Applications in aging are currently geared towards deciphering the underlying connections and networks. "We have to realize that the real strength of computational systems biology in aging is to be able to predict and develop strategies to control cellular networks better as they may be related to age related diseases," said Dr. Kriete, "and our approach is just a first step in this direction."


'/>"/>

Contact: Keri Stedman
keri.stedman@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Related biology news :

1. Fuzzy logic water quality
2. Improved estrogen reception may sharpen fuzzy memory
3. Keck Foundation funds study of biological interactions with nanomaterials
4. New insight into the mechanisms of voltage sensing and transduction in biological processes
5. Book on weeds and invasive plants discusses how to manage them using ecological approaches
6. Microfossils disclose geologic history of eastern California
7. Entomological Society of America recognizes 2007 fellows and honorary members
8. Biogeochemistry -- A window into the Earths ecological health
9. Mellon awards Carnegie Grant for Ecological Monitoring in South Africa
10. Biological warfare: What do you need to know?
11. Entomological Society announces 2007 award winners
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... 2016 Securus Technologies, a leading provider ... public safety, investigation, corrections and monitoring, and the ... five (5) year funding commitment by Securus to ... rehabilitation and reentry support to more inmates and ... 2004, the Prison Entrepreneurship Program (PEP) is an ...
(Date:11/30/2016)... WARSAW, Poland , Nov. 30, 2016 Not many of us ... most crucial aspects of recovery so we need to do it well. Inadequate sleep ... heart problems, high blood pressure, stroke, diabetes, and even cancer. Maybe now ... a Christmas present that could help them to manage their sleep quality? ... ...
(Date:11/29/2016)... 29, 2016 Nearly one billion matches per second ... ... DERMALOG is Germany's ... efficient Identity Management. (PRNewsFoto/DERMALOG Identification Systems) ... DERMALOG is Germany's largest Multi-Biometric supplier: The company's Fingerprint Identification ...
Breaking Biology News(10 mins):
(Date:12/9/2016)... ... December 09, 2016 , ... Aditya Humad, Acting CFO of AxioMed and Managing ... the United States, Axiomed is now gaining interest from Silicon Valley. “It was satisfying ... Humad went on to say that, “We expect interest to continue to rise as ...
(Date:12/9/2016)... 2016 /PRNewswire/ - Portage Biotech Inc. ("Portage" or "the ... to announce that Biohaven has issued today the following ... (PRWEB) Dec 9, 2016 - Biohaven Pharmaceutical ... that the U.S. Food and Drug Administration ("FDA") has ... drug candidate BHV-0223, an orally dissolving tablet being developed ...
(Date:12/8/2016)... ... , ... Lajollacooks4u, San Diego’s premier team building events and cooking events company, ... offerings and company expansion. , This is largely due to its team ... 30 people. Ever since, Lajollacooks4u has seen significant demand for its services from organizations ...
(Date:12/8/2016)... 8, 2016  Biotheranostics today announced that new ... the Breast Cancer Index (BCI) in identifying which ... most at-risk for disease recurrence and might benefit ... three studies advancing the understanding of the value ... biology and inform decisions related to patient treatment. ...
Breaking Biology Technology: