Navigation Links
Fused genes tackle deadly Pierce's disease in grapevines
Date:2/21/2012

A gene fusion research project led by a University of California, Davis, plant scientist delivers a one-two punch to Pierce's disease, a deadly threat to California's world-renowned wine industry.

The study is set for publication the week of Feb. 20 in the early edition of the Proceedings of the National Academy of Sciences.

"Many disease-causing microbes can evade one defensive action by a host plant, but we believe that most microbes would have difficulty overcoming a combination of two immune-system defenses," said UC Davis plant sciences professor Abhaya Dandekar, the lead researcher.

He and his colleagues tested this hypothesis on Xylella fastidiosa, the bacteria responsible for Pierce's disease in grapevines. Strains of the bacteria also attack and damage other host plants, including citrus, stone fruits, almonds, oleander, and certain shade trees, such as oaks, elms, maples and sycamores.

The findings further strengthen UC Davis' standing as a world leader in the science of plant improvement through advances in genetics, genomics, plant breeding and biodiversity.

First noted in California near Anaheim around 1884, Pierce's disease in grapevines is now known to exist in 28 California counties. From 1994 to 2000, the disease destroyed more than 1,000 acres of northern California grapevines, causing $30 million in damages. There is currently no known cure for Pierce's disease.

In grapevines, Xylella fastidiosa is carried from plant to plant by half-inch-long insects known as sharpshooters. The bacteria infect and clog the plant's water-transporting tissue, or xylem. Grapevines with Pierce's disease develop yellow and brown leaves and die within a few years.

To block such infections, the researchers engineered a hybrid gene by fusing together two genes that are responsible for two key functions of the plant's innate immune response: recognizing Xylella fastidiosa as a bacterial invader and destroying its outer membranes, causing the bacteria to die.

The researchers then inserted this hybrid gene into grapevines.

They found that sap from plants genetically engineered with the hybrid gene effectively killed Xylella fastidiosa in the laboratory. And grapevines engineered to carry the hybrid gene had significantly less leaf scorching and xylem clogging, indicating resistance to Pierce's disease.


'/>"/>

Contact: Patricia Bailey
pjbailey@ucdavis.edu
530-752-9843
University of California - Davis
Source:Eurekalert

Related biology news :

1. INCOM Inc. Marks 40th Anniversary as Market Leader in Fused Fiber Optics
2. Electrons get confused
3. Pure fructose frequently confused with high fructose corn syrup
4. Genes may travel from plant to plant to fuel evolution
5. Synthetic protein amplifies genes needed for stem cells
6. Using plants to silence insect genes in a high-throughput manner
7. Same genes linked to early- and late-onset Alzheimers
8. UCSF shares $25-million grant to find epilepsy genes
9. Research team discovers genes and disease mechanisms behind a common form of muscular dystrophy
10. 2 genes affect anxiety, behavior in mice with too much MeCP2
11. Study of skates and sharks questions assumptions about essential genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2017)... 6, 2017 Forecasts by Product ... Readers, by End-Use (Transportation & Logistics, Government & Public ... & Fossil Generation Facility, Nuclear Power), Industrial, Retail, Business ... Are you looking for a definitive report on ... ...
(Date:4/5/2017)... April 4, 2017 KEY FINDINGS ... expand at a CAGR of 25.76% during the forecast ... the primary factor for the growth of the stem ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem cell ... application, and geography. The stem cell market of the ...
(Date:3/30/2017)... March 30, 2017  On April 6-7, 2017, Sequencing.com ... Genome hackathon at Microsoft,s headquarters in ... will focus on developing health and wellness apps that ... Hack the Genome is the first hackathon for ... world,s largest companies in the genomics, tech and health ...
Breaking Biology News(10 mins):
(Date:9/14/2017)... ... , ... Boston Strategic Partners, Inc. (BSP), a life-sciences and ... Research (HEOR) and ‘big data’ to provide in-depth analysis of pneumonia patients characteristics, ... trillion with nearly 1/3 spent on hospitalizations. BSP has access to real-world data ...
(Date:9/14/2017)... ... September 14, 2017 , ... ... analytics solutions, today announced that its Anzo Smart Data Lake has been named ... includes technologies and solutions that help organizations succeed in surpassing their knowledge management ...
(Date:9/12/2017)... ... September 12, 2017 , ... Avomeen.com, ... product testing and development companies will be exhibiting at the 16th annual Contract ... Contract Pharma is an educational conference for pharma and bio-pharma professionals ...
(Date:9/12/2017)... ... September 12, 2017 , ... September ... announce that Jeremy Nicholson, Head of the Department of Surgery and Cancer and ... 2018 Wallace H. Coulter Lecture. His presentation, “Analytical Science in Precision Medicine: ...
Breaking Biology Technology: