Navigation Links
Funding for animal testing alternative
Date:8/23/2013

A researcher from Plymouth University Peninsula Schools of Medicine and Dentistry has received an award of 94,365 (Sterling) from the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), for a pilot study to develop the lab-based creation of a type of mouse cell which could be used in place of the live animals for research related to infectious and allergic lung conditions.

Macrophages are crucial components of the immune system and play key roles in the body's defence against invading pathogens. Macrophages can be switched to perform different functions by chemical messengers produced by cells and tissues in response to infection. Some are switched to M2 macrophages which play a role in infections and allergic diseases such as asthma.

More needs to be understood about M2 macrophages if they are to play a part in effective therapies for infections. However, the cells acquired from live mice have a limited lifespan and require the repeated use of the animals.

Dr. Gyorgy Fejer will use the award to establish permanently growing, alternatively activated M2 macrophage cell lines in order to reduce the number of animals currently used to provide such cells for study. His work revolves around mouse lung macrophages which can be grown indefinitely and are available in practically unlimited numbers.

Compared with cell harvesting from a live mouse, the difference is striking: approximately 300,000 cells can be obtained from a mouse, whereas Dr. Fejer and his team can obtain 20-30 million cells from a single tissue culture flask.

This means that scientists who research asthma and pulmonary virus and bacterial infections can for the first time have access to almost limitless cells for study, without the need for live mice.

Dr. Fejer's award is one of several presented to scientists across the UK by NC3Rs for smart approaches to reduce animal use in science. It follows the publication by Dr. Fejer of related findings in the prestigious journal, PNAS Plus.


'/>"/>

Contact: Andrew Gould
andrew.gould@plymouth.ac.uk
University of Plymouth
Source:Eurekalert

Related biology news :

1. Research!America says budget negotiations heighten urgency to protect research funding
2. Research!America says house funding levels for FY13 could undermine medical progress
3. Mainz University Medical Center attracts funding of Alexander von Humboldt Professorship
4. University of Tennessee professor receives funding for clean coal research
5. House funding bill will delay research progress and place new burdens on NIH
6. Space research institute awards funding to promising medical products
7. University of Minnesota receives $13.1 million in DOE funding for 2 new nationwide centers
8. 2 pioneering plant genomics efforts given a funding boost by National Science Foundation
9. State stem cell research funding agency awards $37.3 million to aid UC Irvine efforts
10. University spin-out company shares in £7.9 million marine energy funding boost
11. £12 million funding to tackle devastating livestock and poultry viruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/25/2016)...  Glencoe Software, the world-leading supplier of image data ... provide the data management solution OMERO Plus for the ... Photo - http://photos.prnewswire.com/prnh/20160125/325328LOGO ... Phenotypic analysis measures the characteristics and behavior of ... states such as health and disease, the presence or ...
(Date:1/20/2016)... , Jan. 20, 2016 A market ... to directly benefit from the explosion in genomics knowledge. ... Howe Sound Research. A range of dynamic trends are ... - personalized medicine - pharmacogenomics - pathogen evolution ... with large markets - greater understanding of the role ...
(Date:1/15/2016)... , Jan. 15, 2016 Recent publicized breaches ... to find new ways to ensure data security and ... iOS and Android that ties a ... transforming it into a hardware authorization token. Customer service ... their fingerprint on their KodeKey enabled device to verify ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... Md. , Feb. 10, 2016  The Maryland ... Busch , has announced that University of Maryland School ... PhD, MBA and University of Maryland Medical System President ... of the "Speaker,s Medallion," the highest honor given to ... of Delegates. Dean Reece and Mr. ...
(Date:2/10/2016)... 2016  IsoRay, Inc. (NYSE MKT: ISR), a medical ... radioisotope applications for the treatment of prostate, brain, lung, ... financial results for the second quarter and six months ... --> --> Revenue ... 2016, which ended December 31, 2015, a 12% increase ...
(Date:2/10/2016)... Springfield, MO (PRWEB) , ... February 10, 2016 ... ... company, will attend the International Society of Pharmaceutical Engineering (ISPE) Rocky Mountain Chapter ... of ISPE is expecting to fill more than 100 tables for its annual ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... on Microsoft Azure. On Azure, Arvados provides capabilities for managing and processing genomic ... for Microsoft Azure from major institutions collecting and analyzing genomic data,” said Adam ...
Breaking Biology Technology: