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Functioning of aged brains and muscles in mice made younger
Date:5/4/2014

p's experiments independently of the Wagers group, and "she saw an increase in neural stem cells, and saw increased development of blood vessels in the brain." Rubin said that 3D reconstruction of the brain, and magnetic resonance imaging (MRI) of the mouse brain showed "more new blood vessels and more blood flow," both of which are normally associated with younger, healthier brain tissue." Younger mice, Rubin said, "have a keen sense of olfactory discrimination," they can sense fine differences in odor. "When we tested the young mice, they avoided the smell of mint; the old mice didn't. But the old mice exposed to the blood of the young mice, and those treated with GDF11 did.

"We think an effect of GDF 11 is the improved vascularity and blood flow, associated with increased neurogenesis," Rubin said. "This should have other more widespread effect on other areas of the brain. We do think that, at least in principal, there will be a way to reverse some of the decline of aging with a single protein. It could be that a molecule like GDF 11, or GDF 11 itself, could" reverse the damage of aging.

"It isn't out of question that GDF11," or a drug developed from it, "might be worthwhile in Alzheimer's Disease," Rubin said. "You might be able to separate out the issues of treating the plaque and tangles associated with the disease, and the decline in cognition, and perhaps improve cognition." Wagers said that the two research groups are in discussions with a venture capital group to obtain funding to "be able to do the additional pre-clinical work" necessary before moving GDF 11 into human trials.

"I would wager that the results of this work, together with the other work, will translate into a clinical trial and a treatment," said the stem cell biologist. "but of course that's just a wager."

"We think an effect of GDF 11 is the improved vascularity and blood flow, which is associated with increased neurogenesis," Rubin said. "However, the increased blood flo
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Contact: B. D. Colen
bd_colen@harvard.edu
617-413-1224
Harvard University
Source:Eurekalert  

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