Navigation Links
Functioning of aged brains and muscles in mice made younger
Date:5/4/2014

Cambridge, MA, May 4 - Harvard Stem Cell Institute (HSCI) researchers have shown that a protein they previously demonstrated can make the failing hearts in aging mice appear more like those of young health mice, similarly improves brain and skeletal muscle function in aging mice.

In two separate papers given early online release today by the journal Science which is publishing the papers this coming Friday, Professors Amy Wagers and Lee Rubin, of Harvard's Department of Stem Cell and Regenerative Biology (HSCRB), report that injections of a protein known as GDF11, which is found in humans as well as mice, improved the exercise capability of mice equivalent in age to that of about a 70-year-old human, and also improved the function of the olfactory region of the brains of the older mice they could detect smell as younger mice do.

Rubin and Wagers each said that, baring unexpected developments, they expect to have GDF11 in initial human clinical trials within three to five years. Postdoctoral fellow Lida Katsimpardi is the lead author on the Rubin group's paper, and postdocs Manisha Sinha and Young Jang are the lead authors on the paper from the Wagers group.

Both studies examined the effect of GDF11 in two ways. First, by using what is called a parabiotic system, in which two mice are surgically joined and the blood of the younger mouse circulates through the older mouse. And second, by injecting the older mice with GDF11, which in an earlier study by Wagers and Richard Lee, of Brigham and Women's Hospital who is also an author on the two papers released today, was shown to be sufficient to reverse characteristics of aging in the heart.

Doug Melton, co-chair of HSCRB and co-director of HSCI, reacted to the two papers by saying that he couldn't "recall a more exciting finding to come from stem cell science and clever experiments. This should give us all hope for a healthier future. We all wonder why we were stronger and mentally more
'/>"/>

Contact: B. D. Colen
bd_colen@harvard.edu
617-413-1224
Harvard University
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Heart Damage Repaired By Reprogramming Resident Fibroblasts into Functioning Heart Cells
2. Scientists transform skin cells into functioning liver cells
3. University of Alberta led research may have discovered how memories are encoded in our brains
4. Mice with big brains provide insight into brain regeneration and developmental disorders
5. Preemies brains reap long-term benefits from Kangaroo Mother Care
6. Primates brains make visual maps using triangular grids
7. Musical duets lock brains as well as rhythms
8. Big brains are pricey, guppy study shows
9. Rain Man-like brains mapped at UCSF
10. Exercise for stroke patients brains
11. Human brains are hardwired for empathy, friendship, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Functioning of aged brains and muscles in mice made younger
(Date:7/25/2014)... from 25 countries and 35 states will attend ... Genetics Society of America (GSA) next week at ... will feature close to 500 presentations (including 70 ... gene expression and regulation, functional genomics, chemical biology ... a variety of diseases. , Of special ...
(Date:7/25/2014)... (SB) is a complex congenital central nervous system ... of the neural tubes during the embryonic phase. ... and fecal incontinence and neurocognitive retardation. Such problems ... of life. Researchers at Ankara Physical Medicine and ... functional performance in children with SB, using the ...
(Date:7/25/2014)... Spanish researchers have detected an unknown interaction between microorganisms ... introduced into a droplet of salt water and is ... to create biomineralogical biosaline 3D morphologically complex formations, where ... are revived. The discovery was made by chance with ... the Astrobiology journal and may help to ...
Breaking Biology News(10 mins):Yeast meeting to showcase latest breakthroughs in genetics and molecular biology 2Bacteria manipulate salt to build shelters to hibernate 2
... say geoscientists Kyle Nichols of Skidmore College in Saratoga Springs, ... Burlington, Vt. Nichols and Bierman should know. They,re just ... sparsely populated African country. Usually, western Namibia is a ... "lakes" are nothing more than flats of dried mud. ...
... 2011In a letter to Maine,s two Senators, Susan Collins and ... MS, RD., said, "I would like to thank you for ... particularly important to our statethe amount of potatoes and other ... program. Broihier wrote, "First, there is no question that ...
... and colleagues report that snails successfully crossed Central America, ... in the past million yearsboth times probably by flying ... the bellies of shorebirds and introducing new genes that ... "Just as people use airplanes to fly overseas, marine ...
Cached Biology News:Something odd is happening with Namibia's weather 2Something odd is happening with Namibia's weather 3Hitchhiking snails fly from ocean to ocean 2Hitchhiking snails fly from ocean to ocean 3
(Date:7/25/2014)... -- Research and Markets  has announced the ... report to their offering. ... Metabonomics is the scientific study of chemical processes ... technique that is being widely used in biology, ... molecules that are present in blood, urine, and ...
(Date:7/25/2014)... Lawrence Livermore scientists Charles Westbrook and William ... " The World's Most Influential Scientific Minds ." , ... who were identified by analyzing citation data over the ... highest-impact work (2002-2012 and 2012-2013). The two were selected ... . , "This recognition is a great honor for ...
(Date:7/25/2014)... Sinovac Biotech Ltd. (Nasdaq: SVA ), ... , today announced that it will release its unaudited ... after market close on Thursday, August 14, 2014 EDT. The ... opening on Friday, August 15, 2014, at 8:00 a.m. EDT ... to review the Company,s financial results and provide an update ...
(Date:7/24/2014)... July 24, 2014  Now available is a stem ... Rehealth Regenerative Therapies , located in Guadalajara, ... active people a new health option: stem cell ... age, countless patients suffer from joint and muscle injuries ... muscle tears, torn rotator cuff, tennis elbow, and knee ...
Breaking Biology Technology:Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4Sinovac to Host Conference Call to Report Second Quarter 2014 Unaudited Financial Results 2Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3
... to accelerate commercialization,of personal care ingredients with its proprietary oleosome-based technology ... ... ... Inc. (,Botaneco,), a wholly-owned subsidiary of SemBioSys,Genetics Inc. (,SemBioSys,), today announced that it has ...
... June 30 Exiqon A/S today,received information from Danske ... Livsforsikring and Danske Fund FCP - through,acquisition today of ... of each DKK 1 corresponding to 5,99% of the ... A/S., About Exiqon, Exiqon,s corporate mission is ...
... funding over 10-year ... life of competition, PITTSBURGH, June 27 ... Park Prime,Steakhouse on Pittsburgh,s North Shore Olive earlier this week marking an,end ... total,of $82,500 was awarded throughout all phases this year., The competition ...
Cached Biology Technology:Botaneco announces $4,000,000 financing 2Botaneco announces $4,000,000 financing 3Botaneco announces $4,000,000 financing 4EnterPrize Business Plan Competition Announces Final Phase Winners of Cash Awards Totaling $45,000 2
in vitro Translation, Accessory Products...
... host strains are K-12 derivatives that have ... and glutathione reductase (gor) genes, which greatly ... Studies have shown that expression in Origami(DE3) ... another host even though overall expression levels ...
... ULTROSPEC 6300 (YELLOW), 1 EA. ... the demanding requirements of the Pharmacopoeia in ... with the benefits of being able to ... of 1.0 nm and excellent scanning capability., ...
PHOTOMAN DIRECT COPY CAMERA, 1 EA. Category: Nucleid Acid Detection Systems....
Biology Products: