Navigation Links
Function found for mysterious heart disease gene
Date:4/25/2014

OTTAWA, April 24, 2014 - A new study from researchers at the University of Ottawa Heart Institute (UOHI), published today in Cell Reports, sheds light on a mysterious gene that likely influences cardiovascular health. After five years, UOHI researchers now know how one genetic variant works and suspect that it contributes to the development of heart disease through processes that promote chronic inflammation and cell division.

Researchers at the Ruddy Canadian Cardiovascular Genetics Centre had initially identified a variant in a gene called SPG7 as a potential contributor to coronary artery disease several years ago, but its role in multiple health processes made it difficult to tease out how it affects heart disease.

The gene holds instructions for producing a protein called SPG7. This protein resides in mitochondriathe small power plants of cells that produce the energy cells need to function. SPG7's role is to help break down and recycle other damaged proteins within the mitochondria.

Normally, SPG7 requires a partner protein to activate itself and start this breakdown process. But, in people who carry the genetic variant in question, SPG7 can activate itself in certain circumstances, leading to increased production of free radicals and more rapid cell division. These factors contribute to inflammation and atherosclerosis.

"We think this variant would definitely heighten the state of inflammation, and we know that inflammation affects diabetes and heart disease," said Dr. Stewart, Principal Investigator in the Ruddy Canadian Cardiovascular Genetics Centre and senior author of the study. "Interestingly, the variant also makes people more resistant to the toxic side effects of some chemotherapy drugs."

From an evolutionary perspective, this resistance could help such a genetic variant gain a stable place in the human genome. Between 13 and 15 per cent of people of European descent possess this variant.

"The idea of mitochondria contributing to inflammation isn't new," concluded Dr. Stewart. "But what is new is that we've found one of the switches that regulate this process. We're excited, because once you know where the switches are, you can start looking for ways to turn them on and off."


'/>"/>

Contact: Vincent Lamontagne
vlamontagne@ottawaheart.ca
613-761-4427
University of Ottawa Heart Institute
Source:Eurekalert  

Related biology news :

1. Autologous stem cell therapy improves motor function in chronic stroke victims
2. Amino-functionalized carbon nanotubes act as a carrier for nerve growth factor
3. Proper stem cell function requires hydrogen sulfide
4. Development of new cell models that report circadian clock function
5. Special function of nestin+ neurons in medial septum-diagonal band of Broca in adult rats
6. Scientists uncover startlingly new functional details of common anti-diabetic drugs
7. Light-activated neurons from stem cells restore function to paralyzed muscles
8. Resting-state functional connection during low back pain
9. New functions for junk DNA?
10. Early rehabilitation improves postsurgery neurofunctional outcome in spinal tumor children
11. Aspartic acid in the hippocampus: A biomarker for postoperative cognitive dysfunction
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Function found for mysterious heart disease gene
(Date:6/2/2016)... --  The Weather Company , an IBM Business (NYSE: ... in which consumers will be able to interact with IBM ... voice or text and receive relevant information about the product ... have long sought an advertising solution that can create a ... and valuable; and can scale across millions of interactions and ...
(Date:6/1/2016)... , June 1, 2016 ... in Election Administration and Criminal Identification to Boost Global ... a recently released TechSci Research report, " Global Biometrics ... Region, Competition Forecast and Opportunities, 2011 - 2021", the ... billion by 2021, on account of growing security concerns ...
(Date:5/20/2016)...  VoiceIt is excited to announce its new ... By working together, VoiceIt and VoicePass will offer ... take slightly different approaches to voice biometrics, collaboration ... usability. Both ... "This marketing and technology partnership allows ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT ... Ontario biotechnology company, Propellon Therapeutics ... development and commercialization of a portfolio of first-in-class ... Epigenetic targets such as WDR5 represent an exciting ... significantly in precision medicine for cancer patients. Substantial ...
(Date:6/23/2016)... -- The Biodesign Challenge (BDC), a university competition that asks ... systems and biotechnology, announced its winning teams at the ... York City . The teams, chosen ... MoMA,s Celeste Bartos Theater during the daylong summit. Keynote ... of architecture and design, and Suzanne Lee , ...
(Date:6/23/2016)... , June 23, 2016 Apellis Pharmaceuticals, ... 1 clinical trials of its complement C3 inhibitor, ... and multiple ascending dose studies designed to assess ... of subcutaneous injection in healthy adult volunteers. ... either as a single dose (ranging from 45 ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance Associates® ... provides a free webinar on Performing Quality Investigations: Getting to Root ... CT at no charge. , Incomplete investigations are still a major concern to ...
Breaking Biology Technology: