Navigation Links
Function found for mysterious heart disease gene
Date:4/25/2014

OTTAWA, April 24, 2014 - A new study from researchers at the University of Ottawa Heart Institute (UOHI), published today in Cell Reports, sheds light on a mysterious gene that likely influences cardiovascular health. After five years, UOHI researchers now know how one genetic variant works and suspect that it contributes to the development of heart disease through processes that promote chronic inflammation and cell division.

Researchers at the Ruddy Canadian Cardiovascular Genetics Centre had initially identified a variant in a gene called SPG7 as a potential contributor to coronary artery disease several years ago, but its role in multiple health processes made it difficult to tease out how it affects heart disease.

The gene holds instructions for producing a protein called SPG7. This protein resides in mitochondriathe small power plants of cells that produce the energy cells need to function. SPG7's role is to help break down and recycle other damaged proteins within the mitochondria.

Normally, SPG7 requires a partner protein to activate itself and start this breakdown process. But, in people who carry the genetic variant in question, SPG7 can activate itself in certain circumstances, leading to increased production of free radicals and more rapid cell division. These factors contribute to inflammation and atherosclerosis.

"We think this variant would definitely heighten the state of inflammation, and we know that inflammation affects diabetes and heart disease," said Dr. Stewart, Principal Investigator in the Ruddy Canadian Cardiovascular Genetics Centre and senior author of the study. "Interestingly, the variant also makes people more resistant to the toxic side effects of some chemotherapy drugs."

From an evolutionary perspective, this resistance could help such a genetic variant gain a stable place in the human genome. Between 13 and 15 per cent of people of European descent possess this variant.

"The idea of mitochondria contributing to inflammation isn't new," concluded Dr. Stewart. "But what is new is that we've found one of the switches that regulate this process. We're excited, because once you know where the switches are, you can start looking for ways to turn them on and off."


'/>"/>

Contact: Vincent Lamontagne
vlamontagne@ottawaheart.ca
613-761-4427
University of Ottawa Heart Institute
Source:Eurekalert  

Related biology news :

1. Autologous stem cell therapy improves motor function in chronic stroke victims
2. Amino-functionalized carbon nanotubes act as a carrier for nerve growth factor
3. Proper stem cell function requires hydrogen sulfide
4. Development of new cell models that report circadian clock function
5. Special function of nestin+ neurons in medial septum-diagonal band of Broca in adult rats
6. Scientists uncover startlingly new functional details of common anti-diabetic drugs
7. Light-activated neurons from stem cells restore function to paralyzed muscles
8. Resting-state functional connection during low back pain
9. New functions for junk DNA?
10. Early rehabilitation improves postsurgery neurofunctional outcome in spinal tumor children
11. Aspartic acid in the hippocampus: A biomarker for postoperative cognitive dysfunction
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Function found for mysterious heart disease gene
(Date:1/20/2016)... Jan. 20, 2016  Synaptics Incorporated (NASDAQ: ... solutions, today announced sampling of S1423, its newest ... and small screen applications including smartwatches, fitness trackers, ... round and rectangular shapes, as well as thick ... with moisture on screen, while wearing gloves, and ...
(Date:1/15/2016)... SAN JUAN, Puerto Rico , Jan. 15, 2016 ... forcing companies big and small to find new ways ... data driven culture. iOS and ... their device based on biometrics, transforming it into a ... can request that users swipe their fingerprint on their ...
(Date:1/13/2016)... DUBLIN , January 13, 2016 ... has announced the addition of the  ... - Estimation & Forecast (2015-2020)" ... http://www.researchandmarkets.com/research/7h6hnn/india_biometrics ) has announced the ... & Identification Market - Estimation & ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... , Feb. 8, 2016  CytRx Corporation (NASDAQ: ... company specializing in oncology, today announced that it ... agreement with Hercules Technology Growth Capital, Inc. and ... million in financing. --> ... $25 million of financing under the loan and ...
(Date:2/8/2016)... ... ... Information Management Services ( IMS ) is pleased to announce a major upgrade ... and is so significant it was endowed with a new name, BSI Engage. ... a streamlined layout and a more intuitive format for navigating the system. ...
(Date:2/8/2016)... , Feb. 8, 2016  Diplomat Pharmacy, Inc. (NYSE: DPLO) announced today that its new website ... pharmacy resource–user-centric, story-driven, knowledge-based and mobile-friendly. Visit the ... ... ... "The goal was to ...
(Date:2/5/2016)... N.C. , Feb. 5, 2016  In the ... role for a host of launch activities including the ... of this launch activity is especially high in the ... Best Practices and the Role of Medical ... help companies focused on oncology therapies find better ways ...
Breaking Biology Technology: