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Fruit fly studies guide investigators to misregulated mechanism in human cancers
Date:11/19/2012

MLL3 and undertook a global histone methylation analysis to observe where changes in methylation patterns occurred. They found that H3K4 monomethylation was reduced in enhancer regions.

"MLL3 and MLL4 are mutated in numerous cancers," says Shilatifard. "Researchers have found that many lymphomas have mutations in MLL3 and MLL4."

Herz agrees, noting that mutations in MLL3 and MLL4 are seen in human colorectal cancer, medulloblastoma, breast tumors, and leukemia. "This suggests that activation and deactivation of enhancers could play an important role in cancer pathogenesis," he says. "Understanding which proteins carry out this function or how they control enhancer activity could help us to understand how genes that suppress tumor suppressor genes are deactivated in various cancers."


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Contact: Gina Kirchweger
gxk@stowers.org
816-806-1036
Stowers Institute for Medical Research
Source:Eurekalert  

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