Navigation Links
Fruit fly intestine may hold secret to the fountain of youth
Date:11/2/2011

his, they used genetic engineering techniques to boost the activity of the fruit fly equivalent of the PCG-1 gene. The flies (known as Drosophila melanogaster) have a short lifespan, allowing the scientists to study aging and longevity in ways that aren't as feasible in longer-lived organisms such as mice or human.

The researchers found that boosting the activity of dPGC-1, the fruit fly version of the gene, resulted in greater numbers of mitochondria and more energy-production in flies - the same phenomenon seen in organisms on calorie restricted diets. When the activity of the gene was accelerated in stem and progenitor cells of the intestine, which serve to replenish intestinal tissues, these cellular changes correspond with better health and longer lifespan. The flies lived between 20 and 50 percent longer, depending on the method and extent to which the activity of the gene was altered.

"Their intestines were beautiful," says Christopher L. Koehler, a doctoral-student at University of California San Diego who conducts research in Jones' laboratory. "The flies with the modified gene activity were much more active and robust than the other flies."

Part of the reason for this might be that boosting the fruit fly version of PCG-1 stimulates the stem cells that replenish the intestinal tissues, keeping the flies' intestines healthier. The findings suggest that the fruit fly version of PCG-1 can act as a biological dial for slowing the aging process and might serve as a target for drugs or other therapies to put the breaks on aging and age-related diseases.

"Slowing the aging of a single, important organ - in this case the intestine - could have a dramatic effect on overall health and longevity," Jones says. "In a disease that affects multiple tissues, for instance, you might focus on keeping one organ healthy, and to do that you might be able to utilize PGC-1."


'/>"/>
Contact: Andy Hoang
Ahoang@salk.edu
619-861-5811
Salk Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. How eating fruit and vegetables can improve cancer patients response to chemotherapy
2. Women double fruit, veggie intake with switch to Mediterranean diet plan
3. When it comes to sleep research, fruit flies and people make unlikely bedfellows
4. Scientists unlock possible aging secret in genetically altered fruit fly
5. Tuning in on cellular communication in the fruit fly
6. Fruit flies sick from mating
7. Caltech researchers train computers to analyze fruit-fly behavior
8. Drinking 100 percent fruit juice is associated with lower risk of obesity and metabolic syndrome
9. P[acman]-generated fruit fly gene library: A new research tool
10. Sugarcoating fruit fly development
11. Scripps Research scientists observe human neurodegenerative disorder in fruit flies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fruit fly intestine may hold secret to the fountain of youth
(Date:7/11/2014)... new report from the Wildlife Conservation Society shows ... help economically valuable species such as lobster, conch, ... help re-colonize nearby reef areas. , The reporttitled ... systematic review of research literature from no-take areas ... Dr. Craig Dahlgren, a recognized expert in marine ...
(Date:7/11/2014)... fires burning in eastern New South Wales, Australia when ... At 03:35 UTC on July 11 (12:35 p.m. local ... over eastern New South Wales (NSW), the Moderate Resolution ... of the region and spotted smoke (light brown) from ... bands, are outlined in red. , The New South ...
(Date:7/11/2014)... and Mineral Research awarded Michael F. Holick, PhD, MD, ... 2014 Louis V. Avioli Award. Holick, a professor of ... for revolutionizing the understanding of vitamin D and its ... a member of the American Society for Bone and ... mineral basic research. It is named for ASBMR,s first ...
Breaking Biology News(10 mins):Belize's lobster, conch, and fish populations rebuild in no-take zones 2BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2
... H. Blackburn, PhD, 60, of the University of California, San ... in Physiology or Medicine. Blackburn shares the award with ... and Jack W. Szostak of Harvard Medical School. The ... normal cell function, as well as in cell aging and ...
... Upgrade Extends Range to Beyond-Line-of-Sight Communications Through Integration ... Terminals , WASHINGTON, Oct. 5 ... (NYSE: HRS ), an international communications and ... broadband satellite data capability to its JTRS-approved Falcon ...
... WASHINGTON (October 5, 2009) To help draw attention to ... (PCNA) has released findings from a new national consumer survey ... the leading cause of death in the U.S. The ... Americans incorrectly believe that the processes related to heart disease ...
Cached Biology News:UCSF scientist receives Nobel Prize in Physiology or Medicine 2UCSF scientist receives Nobel Prize in Physiology or Medicine 3Harris Corporation Adds Broadband Satellite Data Mode to JTRS-Approved Falcon III(R) AN/PRC-117G Multiband Manpack Radio 2Harris Corporation Adds Broadband Satellite Data Mode to JTRS-Approved Falcon III(R) AN/PRC-117G Multiband Manpack Radio 3Americans concerned about heart health, but not proactive enough to prevent it 2
(Date:7/12/2014)... (PRWEB) July 12, 2014 ... various reagents used in the life science ... the life science reagents market towards remarkable ... manufacturers and providers of life science reagents. ... Report: http://www.transparencymarketresearch.com/life-sciences-reagents-analytical-reagents.html . , The global ...
(Date:7/11/2014)... , July 11, 2014 ... to announce the appointment of John P. Donoghue ... Biotech   in  Geneva . The ... Campus Biotech in Geneva , has ... recognised neuroscientists. John P. Donoghue , founder of ...
(Date:7/10/2014)... Canada (PRWEB) July 10, 2014 ... present in very low abundance and are often ... challenging and time-consuming. , Join presenters Dr. Rowel ... and Dr. John Anders, Head of Quality at ... spectrometer-based approach that can speed detection and quantitation ...
(Date:7/10/2014)... Poway, CA (PRWEB) July 10, 2014 Robert ... Regenerative Veterinary Medicine company, is proud to announce the relaunch ... Pets, launching with a new series called “ What are ... to give an honest and straightforward foundation in the basics ... an educated decision on the right type of treatment when ...
Breaking Biology Technology:Transparency Market Research: Life Science Reagents Market- PCR Reagent Kits, Cell and Tissue Culture, Flow Cytometry, Electrophoresis and Chromatography 2Transparency Market Research: Life Science Reagents Market- PCR Reagent Kits, Cell and Tissue Culture, Flow Cytometry, Electrophoresis and Chromatography 3John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 3Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3
... (NYSE: WAT ) announced today that ... Prof. Alison Ashcroft of the University of Leeds ... Research Publication in the Journal of the American ... titled, Monitoring Copopulated Conformational States During Protein ...
... The Gamida Cell-Teva Joint Venture,announced today that five prestigious cord blood ... joined the Excel study. , , Participating clinical ... of Barcelona, Barcelona, Principal Investigator, Dr. Enric Carreras, ... Principal Investigator, Dr. Cristina Arbona, MD, ...
... NeurogesX, Inc. (Nasdaq: NGSX ), ... pain management therapies, announced today that Anthony DiTonno, President ... the 8th Annual Needham Life Sciences Conference on Wednesday, ... Stephen Ghiglieri, Chief Financial Officer, will also be available ...
Cached Biology Technology:First ASMS Hites Award for Outstanding Research Publication Presented to Prof. Alison Ashcroft for Her Use of Waters Synapt HDMS System to Explore Protein Complexes 2First ASMS Hites Award for Outstanding Research Publication Presented to Prof. Alison Ashcroft for Her Use of Waters Synapt HDMS System to Explore Protein Complexes 3Five Cord Blood Transplant Centers in Catalonia and Valencia Join a Study to Test a New Technique to Treat Leukemia and Lymphoma 2Five Cord Blood Transplant Centers in Catalonia and Valencia Join a Study to Test a New Technique to Treat Leukemia and Lymphoma 3NeurogesX to Present at Needham Life Sciences Conference 2NeurogesX to Present at Needham Life Sciences Conference 3
Ethylene glycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid...
Kit Components: Anti-PARP LumiGLO Chemiluminescent Substrate Immunoblot Blocking Reagent Pyronin Y Reagent Goat Anti-Rabbit IgG, HRP conjugate Double-It Reagent Film Exposure Folders Autor...
ssDNA from PCR DNA in less than 1 hour. No gels, columns, or slurries. Sequence from high quality ssDNA: clearer reads, longer runs....
... Kit, 100 reactions. Prepare circular DNA ... h.Generate microgram quantities of template DNA ... amplified DNA directly for cycle sequencing ... M13 liquid cultures, colonies, plaques, or ...
Biology Products: