Navigation Links
Fruit flies show how salmonella escapes immune defenses
Date:4/16/2008

Salmonella are wily and obnoxious bacterial invaders--escape artists capable of evading multiple immune responses and causing a harsh and debilitating intestinal infection.

Researchers have come closer to understanding how these bacteria manage to thwart two major categories of immune defenses at once and set up shop in a host organism. New results are reported in the April 2008 issue of the journal Cell Host & Microbe.

The Emory University research team used a transgenic fruit fly (drosophila) model to test a group of "effector proteins," also known as "virulence factors," secreted by invading organisms to usurp the host immune response for their own benefit.

They found that one of these proteins, named AvrA, not only shuts down the key immune signaling pathways JNK and NF-kB, but also turns off the fail safe system organisms have evolved to respond to irreversible threats. This ultimate immune defense, called apoptosis, eliminates invaders along with the infected cells through a system of programmed cell death.

In previous research, the scientists had showed that AvrA could suppress some aspects of immune system signaling in cell culture, but they wanted to study the protein in a whole animal system.

"Bacterial proteins are notoriously difficult to study," says Andrew Neish, MD, Emory professor of pathology and laboratory medicine and the study's lead scientist. "Using the drosophila system allowed us to express bacterial proteins in a controlled fashion. We were able to study salmonella infection and the associated proteins and signaling mechanisms in a whole animal, which gave us information we could not have gained from a cell culture dish."

To evaluate the effects of AvrA in natural salmonella infection in mammals, the scientists used a mouse model of salmonella infection and found that AvrA suppressed the same immune signaling pathways and apoptotic reaction as in the drosophila model. A mutant f
'/>"/>

Contact: Sarah Goodwin
sgoodwi@emory.edu
404-727-3366
Emory University
Source:Eurekalert

Page: 1 2

Related biology news :

1. CSHL scientists identify a mechanism that helps fruit flies lock-in memories
2. Like sweets? Youre more like a fruit fly than you think...
3. Crop scientists discover gene that controls fruit shape
4. Researchers create mathematical model of fruit fly eyes
5. The precise role of seminal proteins in sustaining post-mating responses in fruit flies
6. Kids eat more fruits, vegetables when schools offer salad bar
7. Tiny pest-eating insect fights fruit flies
8. Genome comparison of 12 fruit fly species
9. International team compares 12 fruit fly genomes
10. Ripe fruit preferred
11. Chemical in red wine, fruits and vegetables stops cancer, heart disease, depending on the dose
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... , April 14, 2015  HYPR Corp. ... Online (FIDO ® ) Alliance tm , an ... FIDO members commit to share technology and collaborate ... that are interoperable, more secure and private, and ... biometric identity verification that protects sensitive user information ...
(Date:4/10/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ) ... Profiles - NEC" report to their offering. ... continue to supply a range of IT security management ... focus on the development of a Big Data and ... the Asia-Pacific region is a ...
(Date:4/2/2015)... In the current eight ... the strongest competitors, showing outstanding performance in recognition ... is capable of a throughput of 5.000.000 fingerprints ... be ten times faster than most competitors and ...      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ) , ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3NEC Security Competitive Profile 2015 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3
... University biologists are part of an international research team ... remote Arctic lake provides compelling evidence of unprecedented environmental ... "Our findings show that the last several decades have ... Neal Michelutti, a research scientist at the Paleoecological Environmental ...
... An analysis of sediment cores indicates that biological and chemical ... the past 200,000 years and likely are the result of ... the University of Colorado at Boulder. While environmental ... shown to be tightly linked with natural causes of climate ...
... new ways to fight cancer and other diseases have ... circadian rhythm, says Liheng Shi, a researcher in Texas ... the roughly 24-hour cycle of physiological activities of humans, ... have had their research, currently focusing on the circadian ...
Cached Biology News:Queen's scientists on international team discover 'ecologically unique' changes in Arctic lake 2Arctic lake sediments show warming, unique ecological changes in recent decades 2Arctic lake sediments show warming, unique ecological changes in recent decades 3Texas A&M researchers find new mechanism for circadian rhythm 2
(Date:4/20/2015)... Texas , April 20, 2015 ... surgeons for healing bone injuries. The orthobiologics market is ... opportunities for its stakeholders. The global orthobiologics market report ... forecast of revenue. The global orthobiologics market was valued ... reach $7,900.2 million by 2019, at a CAGR of ...
(Date:4/20/2015)... , April 20, 2015  Eli Lilly and ... data from several targeted cancer therapies, reflecting Lilly,s diverse ... (AACR) Annual Meeting 2015, held April 18-22 in ... Cancer Discoveries to Patients" is the theme of this ... Lilly,s commitment to broadening its portfolio of therapies that ...
(Date:4/20/2015)... TORONTO , April 20, 2015 /CNW/ - Portage ... Canadian Securities Exchange: PBT.U), is pleased to announce that ... completed a collaborative research study that showed one of ... reduces inflammation in brain tissue through inhibition of NFkB ... The permeability of the blood brain ...
(Date:4/20/2015)... Global Stem Cells Group ... an annual gathering of aesthetic medicine experts and innovators. ... to introduce the company’s brand new training course that ... cell techniques. , The course is designed to ... aesthetic field, including facial aging caused by volume loss. ...
Breaking Biology Technology:Global Orthobiologics Market is Expected to Reach $7,900.2 Million by 2019, at a CAGR of 6.7% from 2014 to 2019 2Global Orthobiologics Market is Expected to Reach $7,900.2 Million by 2019, at a CAGR of 6.7% from 2014 to 2019 3Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 2Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 3Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 4Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 5Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 6Portage's CPP Platform Delivers a Peptide Cargo Across Blood Brain Barrier 2Portage's CPP Platform Delivers a Peptide Cargo Across Blood Brain Barrier 3Global Stem Cells Group to Host Featured Speaker at The Aesthetic Meeting 2015 in Montreal 2Global Stem Cells Group to Host Featured Speaker at The Aesthetic Meeting 2015 in Montreal 3
... STOCKHOLM, January 21 Richter-Helm,BioLogics GmbH & Co. ... for the development and manufacturing of Athera,s novel ... binding of the,protein, Annexin A5, to endothelium. The ... of patients with Acute Coronary Syndrome and who,are ...
... Pharmaceuticals, Inc. (NYSE Alternext US: IMM.BC) today announced ... Company, LLP as its independent registered public accounting ... Company,s independent registered public accounting firm was approved ... appointment will result in cost savings for Immtech. ...
... 20 /PRNewswire-FirstCall/ - Vasogen Inc. (NASDAQ: VSGN ; ... Deficiency Letter on January 13, 2009, indicating that it ... set forth in Nasdaq Marketplace Rule 4350(c)(1) (the "Rule"). ... a Director, which was announced publicly in a January ...
Cached Biology Technology:Richter-Helm and Athera Biotechnologies Partner in Development of Recombinant Protein to Treat Cardiovascular Disease 2Richter-Helm and Athera Biotechnologies Partner in Development of Recombinant Protein to Treat Cardiovascular Disease 3Immtech Announces Appointment of Virchow Krause as Independent Registered Public Accounting Firm 2Vasogen Complies with NASDAQ Marketplace Rule 4350(c)(1) 2
Mouse Nodal Affinity Purified Polyclonal Ab...
Immunogen: Full length M32 fusion protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Human TFPI Affinity Purified Polyclonal Ab Protein Family: Coagulation, Inflammation, Serine Protease Regulators...
Prostaglandin E2 Luminex Standard Product Lines: Unspecified...
Biology Products: