Navigation Links
Fruit flies show how salmonella escapes immune defenses
Date:4/16/2008

Salmonella are wily and obnoxious bacterial invaders--escape artists capable of evading multiple immune responses and causing a harsh and debilitating intestinal infection.

Researchers have come closer to understanding how these bacteria manage to thwart two major categories of immune defenses at once and set up shop in a host organism. New results are reported in the April 2008 issue of the journal Cell Host & Microbe.

The Emory University research team used a transgenic fruit fly (drosophila) model to test a group of "effector proteins," also known as "virulence factors," secreted by invading organisms to usurp the host immune response for their own benefit.

They found that one of these proteins, named AvrA, not only shuts down the key immune signaling pathways JNK and NF-kB, but also turns off the fail safe system organisms have evolved to respond to irreversible threats. This ultimate immune defense, called apoptosis, eliminates invaders along with the infected cells through a system of programmed cell death.

In previous research, the scientists had showed that AvrA could suppress some aspects of immune system signaling in cell culture, but they wanted to study the protein in a whole animal system.

"Bacterial proteins are notoriously difficult to study," says Andrew Neish, MD, Emory professor of pathology and laboratory medicine and the study's lead scientist. "Using the drosophila system allowed us to express bacterial proteins in a controlled fashion. We were able to study salmonella infection and the associated proteins and signaling mechanisms in a whole animal, which gave us information we could not have gained from a cell culture dish."

To evaluate the effects of AvrA in natural salmonella infection in mammals, the scientists used a mouse model of salmonella infection and found that AvrA suppressed the same immune signaling pathways and apoptotic reaction as in the drosophila model. A mutant f
'/>"/>

Contact: Sarah Goodwin
sgoodwi@emory.edu
404-727-3366
Emory University
Source:Eurekalert

Page: 1 2

Related biology news :

1. CSHL scientists identify a mechanism that helps fruit flies lock-in memories
2. Like sweets? Youre more like a fruit fly than you think...
3. Crop scientists discover gene that controls fruit shape
4. Researchers create mathematical model of fruit fly eyes
5. The precise role of seminal proteins in sustaining post-mating responses in fruit flies
6. Kids eat more fruits, vegetables when schools offer salad bar
7. Tiny pest-eating insect fights fruit flies
8. Genome comparison of 12 fruit fly species
9. International team compares 12 fruit fly genomes
10. Ripe fruit preferred
11. Chemical in red wine, fruits and vegetables stops cancer, heart disease, depending on the dose
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... supported by the National Science Foundation (NSF), counters ... accelerates atmospheric warming, indicating instead that certain Arctic ... into the atmosphere. , The study, published ... focuses on thermokarst lakes, which occur as permafrost ... melted fresh water, converting what was previously frozen ...
(Date:7/31/2014)... DARIEN, IL Researchers who studied 100 twin pairs have ... function normally on less than six hours of sleep per ... resistance to the effects of sleep deprivation. , Results show ... BHLHE41 gene had an average nightly sleep duration of ... than the non-carrier twin, who slept for about six hours ...
(Date:7/31/2014)... scientists from Spain, France, and the U.S. has ... the oldest definitive member of the tribe Omaliini ... discovery and description were made possible through the ... technique, which allows the detailed study of otherwise ... is described in the journal Annals of ...
Breaking Biology News(10 mins):Certain Arctic lakes store more greenhouse gases than they release 2Study of twins discovers gene mutation linked to short sleep duration 2
... New findings from epidemiology and observational studies show ... unique demographic characteristics suggest the problem may be worse ... Latino population age, we are going to see the ... said Amelie G. Ramirez, Dr.P.H., director of the Institute ...
... , This release is available in French . ... the mechanism behind sexual mate selection has been resolved. According to ... de Montral researchers have discovered a molecular switch that becomes activated ... knows that a potential mate is close-by and healthy enough to ...
... melts into place, snugly fitting to the brain,s surface. ... monitor and control seizures, and to transmit signals from the ... implants have the potential to maximize the contact between electrodes ... They could provide a platform for a range of devices ...
Cached Biology News:Cancer health disparities research highlighted at AACR 101st Annual Meeting 2010 2Cancer health disparities research highlighted at AACR 101st Annual Meeting 2010 3Cancer health disparities research highlighted at AACR 101st Annual Meeting 2010 4Cancer health disparities research highlighted at AACR 101st Annual Meeting 2010 5Cancer health disparities research highlighted at AACR 101st Annual Meeting 2010 6Cancer health disparities research highlighted at AACR 101st Annual Meeting 2010 7Study reveals a mechanism for mate selection 2A brain-recording device that melts into place 2A brain-recording device that melts into place 3
(Date:7/31/2014)... August 01, 2014 “2014 ... Polyurethane Resin Industry” is a professional and ... The report introduces Polyurethane Resin basic information, ... chain structure and industry overview. This research ... domestic market as well as global industry ...
(Date:7/31/2014)... -- Nearly 20,000 medical professionals and healthcare leaders gathered ... Lab Expo in Chicago from ... research and technology that will advance medicine and get ... Wednesday, July 30, more than 19,500 attendees had registered ... Expo, with more than 10,000 of these attendees coming ...
(Date:7/31/2014)... mathematician (1912-1954), is famous for a number of breakthroughs, ... 1936 he published a paper, which laid the foundation ... a computer algorithm. He next played a pivotal role ... cracked the German military codes, enabling the Allies to ... the late 1940,s he turned his attention to artificial ...
(Date:7/31/2014)... part of the mouse brain in a way that ... view. Their imaging technique allows zooming in and out ... enabled the team to watch brain cells light up ... represent a step toward better understanding how our own ... Neuron . , In the past, researchers often ...
Breaking Biology Technology:Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 2Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 3Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 4Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 2Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 3A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 2A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 3New mapping approach lets scientists zoom in and out as the brain processes sound 2
... community organizations to ... proactively get the job done, NEWARK, N.J., Aug. ... non-profit organization to utilize its,Ogiene(TM) FE technology to bring 10,000 mobile ... those families so desperately in need,of biohazard-free housing., Dr. Andy ...
... Product Safety Commission (CPSC) to carry out its mandate with ... toy trains bodes poorly for its ability to oversee the ... a new report released by the Project on Emerging Nanotechnologies ... the CPSC are being used in the Olympic Games in ...
... Fla., Aug. 21 Bioheart, Inc.,(Nasdaq: BHRT ... and,biologics that help monitor, diagnose and treat heart ... $1 million unsecured,loan from Rogers Telecommunications Limited. This ... or Bioheart,s repayment of its loan from BlueCrest,Capital. ...
Cached Biology Technology:BioNeutral Signs Agreement With a Non-profit for Long-Term Removal of Formaldehyde to Save 10,000 Mobile Homes in Louisiana 2Consumer Product Safety Commission not ready for nanotech 2Consumer Product Safety Commission not ready for nanotech 3Bioheart, Inc. Announces Additional Funding Support 2Bioheart, Inc. Announces Additional Funding Support 3Bioheart, Inc. Announces Additional Funding Support 4
... Library Panels were designed for full-length gene ... PCRs to identify the desired cDNA clone. ... a 96-well "Master Plate," where each well ... identified the positive well(s) by gel electrophoresis ...
... The DSQ II (Dual-Stage Quadrupole) ... the world leader in analytical instrumentation, introduces ... the DSQ II. Based on the ... DSQ and PolarisQ GC/MS systems, the DSQ ...
... cDNA Library Panels were designed for full-length ... of PCRs to identify the desired cDNA ... in a 96-well "Master Plate," where each ... Having identified the positive well(s) by gel ...
... Micro Kit provides a fast and simple ... of protein samples. The kit is based ... resin as an ion exchanger. Salts such ... poor affinities for Norgens resin and are ...
Biology Products: