Navigation Links
Frozen flies may yield secrets for human organ transplants
Date:8/19/2010

CAMDEN When kitchens become infiltrated with fruit flies, especially during the dog days of summer, homeowners might wish that the flying pests would just turn to ice.

The fruit fly Drosophila melanogaster does boast a powerful genetic system making it an ideal organism to test a cool new discovery: how an enzyme regulates body energy levels. Shutting off this molecular thermostat could result in a newfound cold tolerance that has multiple applications, including extending the 24-hour window donated organs now have for optimum use.

Thanks to a $385,419 grant from the National Institute of Health, a team of RutgersCamden biologists is working to engineer cold tolerant fruit flies and ultimately human cells within the next three years.

This research breakthrough can be credited to Daniel Shain, a professor of biology at RutgersCamden, who has traveled the globe seeking knowledge on how ice worms don't just survive in glaciers, but thrive. When Shain identified a key enzyme that helps ice worms do this AMP phosphatase he tapped Nir Yakoby, an expert Drosophila geneticist and assistant professor of biology at RutgersCamden, to create this cold-tolerant fruit fly.

"The goal is to make human cells survive on ice. Twenty-four hours on ice is pushing it and many people die waiting," says Shain, who is scheduled to travel to Tibet next year to observe ice worms in the vicinity. "We're lucky to have an expert Drosophila geneticist on campus to test this genetic switch."

Not just the ice worm lives on ice; the RutgersCamden research team, which includes undergraduate and graduate students, observed how other organisms, like bacteria, fungi, and algae, also are breaking through their internal thermostats.

"Shain accomplished this switch in mono-cell organisms and now we are going further up into the evolutionary tree to a more complex species," offers Yakoby, who joined the RutgersCamden faculty last year after conducting postdoctoral research at Princeton University's Lewis Sigler Institute for Integrative Genomics. "If we can get these human cells to survive on ice, we should expect organs to do the same. Organs are just a collection of cells."

A graduate of the University of New Hampshire, where he earned both his bachelor's and master's degrees, Shain earned his doctorate from Colorado State University and held a postdoctoral fellowship through the national Institute of Health at the University of California-Berkeley.

Yakoby, who earned his undergraduate and doctoral degrees from Hebrew University in Israel, teaches genetics at RutgersCamden. Both Shain and Yakoby are active members of the RutgersCamden Center for Computational and Integrative Biology, which offers doctoral and graduate programs and strives to determine the quantitative organizational principles of complex biological systems, using a combination of theoretical and experimental approaches.


'/>"/>

Contact: Cathy Donovan
catkarm@camden.rutgers.edu
856-225-6627
Rutgers University
Source:Eurekalert

Related biology news :

1. Creation of the first frozen repository for Hawaiian coral
2. Late-surviving megafauna exposed by ancient DNA in frozen soil
3. Frozen assets: NIAID researchers turn to unique resource for clues to norovirus evolution
4. ICSI or IVF: Babies born from frozen embryos do just as well
5. A tiny frozen microbe may hold clues to extraterrestrial life
6. Butterflies shed light on how some species respond to global warming
7. From butterflies wings to bank notes -- how natures colors could cut bank fraud
8. Resistant wheat rebuilds cell walls when attacked by Hessian flies
9. As monarch butterflies journey north, gardeners can help protect species, researcher says
10. Male or female? In flies, some cells cant tell
11. Water may not run uphill, but it practically flies off new surface
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/12/2016)... 2016 WearablesResearch.com , a brand of ... results from the Q1 wave of its quarterly wearables ... consumers, receptivity to a program where they would receive ... insurance company. "We were surprised to see ... Michael LaColla , CEO of Troubadour Research, "primarily because ...
(Date:4/26/2016)... and LONDON , April ... part of EdgeVerve Systems, a product subsidiary of ... today announced a partnership to integrate the Onegini ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... their customers enhanced security to access and transact ...
(Date:4/14/2016)... 2016 BioCatch ™, the ... announced the appointment of Eyal Goldwerger as ... Goldwerger,s leadership appointment comes at a time of ... deployment of its platform at several of the world,s ... discerns unique cognitive and physiological factors, is a winner ...
Breaking Biology News(10 mins):
(Date:6/23/2016)...  The Biodesign Challenge (BDC), a university competition that ... living systems and biotechnology, announced its winning teams at ... New York City . The teams, ... at MoMA,s Celeste Bartos Theater during the daylong summit. ... curator of architecture and design, and Suzanne Lee ...
(Date:6/23/2016)... ... ... STACS DNA Inc., the sample tracking software company, today announced that Dr. ... STACS DNA as a Field Application Specialist. , “I am thrilled that Dr. ... STACS DNA. “In further expanding our capacity as a scientific integrator, Hays brings a ...
(Date:6/23/2016)... Calif. , June 23, 2016  Blueprint Bio, ... biological discoveries to the medical community, has closed its ... Matthew Nunez . "We have received ... with the capital we need to meet our current ... essentially provide us the runway to complete validation on ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... the Pennsylvania Convention Center and will showcase its product’s latest features from June ... be presenting a scientific poster on Disrupting Clinical Trials in The Cloud during ...
Breaking Biology Technology: