Navigation Links
Frozen flies may yield secrets for human organ transplants
Date:8/19/2010

CAMDEN When kitchens become infiltrated with fruit flies, especially during the dog days of summer, homeowners might wish that the flying pests would just turn to ice.

The fruit fly Drosophila melanogaster does boast a powerful genetic system making it an ideal organism to test a cool new discovery: how an enzyme regulates body energy levels. Shutting off this molecular thermostat could result in a newfound cold tolerance that has multiple applications, including extending the 24-hour window donated organs now have for optimum use.

Thanks to a $385,419 grant from the National Institute of Health, a team of RutgersCamden biologists is working to engineer cold tolerant fruit flies and ultimately human cells within the next three years.

This research breakthrough can be credited to Daniel Shain, a professor of biology at RutgersCamden, who has traveled the globe seeking knowledge on how ice worms don't just survive in glaciers, but thrive. When Shain identified a key enzyme that helps ice worms do this AMP phosphatase he tapped Nir Yakoby, an expert Drosophila geneticist and assistant professor of biology at RutgersCamden, to create this cold-tolerant fruit fly.

"The goal is to make human cells survive on ice. Twenty-four hours on ice is pushing it and many people die waiting," says Shain, who is scheduled to travel to Tibet next year to observe ice worms in the vicinity. "We're lucky to have an expert Drosophila geneticist on campus to test this genetic switch."

Not just the ice worm lives on ice; the RutgersCamden research team, which includes undergraduate and graduate students, observed how other organisms, like bacteria, fungi, and algae, also are breaking through their internal thermostats.

"Shain accomplished this switch in mono-cell organisms and now we are going further up into the evolutionary tree to a more complex species," offers Yakoby, who joined the RutgersCamden faculty last year after conducting postdoctoral research at Princeton University's Lewis Sigler Institute for Integrative Genomics. "If we can get these human cells to survive on ice, we should expect organs to do the same. Organs are just a collection of cells."

A graduate of the University of New Hampshire, where he earned both his bachelor's and master's degrees, Shain earned his doctorate from Colorado State University and held a postdoctoral fellowship through the national Institute of Health at the University of California-Berkeley.

Yakoby, who earned his undergraduate and doctoral degrees from Hebrew University in Israel, teaches genetics at RutgersCamden. Both Shain and Yakoby are active members of the RutgersCamden Center for Computational and Integrative Biology, which offers doctoral and graduate programs and strives to determine the quantitative organizational principles of complex biological systems, using a combination of theoretical and experimental approaches.


'/>"/>

Contact: Cathy Donovan
catkarm@camden.rutgers.edu
856-225-6627
Rutgers University
Source:Eurekalert

Related biology news :

1. Creation of the first frozen repository for Hawaiian coral
2. Late-surviving megafauna exposed by ancient DNA in frozen soil
3. Frozen assets: NIAID researchers turn to unique resource for clues to norovirus evolution
4. ICSI or IVF: Babies born from frozen embryos do just as well
5. A tiny frozen microbe may hold clues to extraterrestrial life
6. Butterflies shed light on how some species respond to global warming
7. From butterflies wings to bank notes -- how natures colors could cut bank fraud
8. Resistant wheat rebuilds cell walls when attacked by Hessian flies
9. As monarch butterflies journey north, gardeners can help protect species, researcher says
10. Male or female? In flies, some cells cant tell
11. Water may not run uphill, but it practically flies off new surface
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2017)... Florida , April 17, 2017 NXT-ID, ... technology company, announces the filing of its 2016 Annual Report on ... and Exchange Commission. ... on Form 10-K is available in the Investor Relations section of ... as on the SEC,s website at http://www.sec.gov . ...
(Date:4/11/2017)... 11, 2017 Research and Markets has announced ... report to their offering. ... global eye tracking market to grow at a CAGR of 30.37% ... Tracking Market 2017-2021, has been prepared based on an in-depth market ... landscape and its growth prospects over the coming years. The report ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute ... Allen Cell Explorer: a one-of-a-kind portal and dynamic digital ... 3D imaging data, the first application of deep learning ... human stem cell lines and a growing suite of ... platform for these and future publicly available resources created ...
Breaking Biology News(10 mins):
(Date:7/14/2017)... (PRWEB) , ... July 13, 2017 , ... ... linearity and calibration verification test kit has received US FDA 510 (k) clearance ... a human plasma matrix, evaluates D-Dimer. Each VALIDATE® D-Dimer kit, prepared using the ...
(Date:7/13/2017)... (PRWEB) , ... July 13, 2017 , ... Thousands of ... and August for the National Aeromodeling Championships (Nats). Pilots come to Muncie to compete ... to earn spots on US teams that participate in world championships. , RC Pylon ...
(Date:7/13/2017)... ... July 13, 2017 , ... In’Tech Medical SAS ( http://www.intech-medical.com ... the completion of a major transaction with Eurazeo PME. The reputable French private ... alliance fuels In’Tech Medical’s service offerings while leveraging the company’s manufacturing expertise and ...
(Date:7/13/2017)... (PRWEB) , ... July 13, 2017 , ... ... Technology Center, Inc. (FITCI), has experienced robust growth in the past year after ... nonprofit has launched several Entrepreneurial Acceleration Programs and expanded its board of directors ...
Breaking Biology Technology: