Navigation Links
Frozen assets: NIAID researchers turn to unique resource for clues to norovirus evolution
Date:10/1/2009

ose sequences to gene sequences of contemporary GII.4 noroviruses. The comparison allowed the investigators to determine how much the archival viruses differed from the most recent representatives of the same genotype and, thus, to calculate how quickly the GII.4 genotype is evolving.

Currently, there are no antiviral drugs specifically targeted to noroviruses, but the new knowledge about which segments of the norovirus genome change the least could aid in the development of novel drugs that could be targeted at those more genetically static portions of the virus, say the researchers. Noroviruses, like influenza viruses, mutate readily and evolve rapidly, explains Dr. Green. If vaccines against noroviruses become possible in the future, researchers would need to take into account shifts in the virus's genetic make-up and reformulate the vaccines to match the virus, she adds. However, unlike influenza viruses, noroviruses cannot be grown in the lab, raising an additional hurdle to vaccine development.

"By examining the history of norovirus evolution contained within these archival samples, we can see how the virus has changed during this time, and we also can better predict how the virus is likely to change in the future," says Dr. Bok. If scientists one day crack the problem of growing norovirus in the lab, information about the rate of evolution will be invaluable to developing vaccines, adds Dr. Green.

"This research is the first to reveal the speed at which the molecular clock of norovirus runs," says Dr. Green. Dr. Green and her colleagues are now looking at stool samples from the 1960s in Dr. Kapikian's collection. If norovirus can be detected in those samples, knowledge about the ancestry and rate of evolution of this virus will be further expanded.


'/>"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Children born from frozen embryos weigh more and do better than those born after fresh transfer
2. A tiny frozen microbe may hold clues to extraterrestrial life
3. ICSI or IVF: Babies born from frozen embryos do just as well
4. NIAID announces grants to stimulate food allergy research
5. AVAC comments on NIAID decision not to move forward with PAVE 100 Trial
6. NIAID announces 25 new awards to develop radiation countermeasures
7. NIAID funds studies of how SARS and bird flu evade antiviral responses
8. NIAID scientists to speak on range of infectious disease topics at major scientific meeting
9. Researchers identify proteins involved in new neurodegenerative syndrome
10. Texas researchers and educators head for Antarctica
11. MGH researchers describe new way to identify, evolve novel enzymes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... A ground breaking new book that brings together two ... to raise the profile of insect fossils through stunning ... David Penney and James E Jepson, details the incredible ... world, setting the scene for what these remarkable fossils ... and even the future of our planet. Like the ...
(Date:7/29/2014)... study from UC San Francisco is the first to ... overtime and accelerate cellular aging, these negative effects may ... sleeping well. , "The study participants who exercised, ... than the ones who didn,t maintain healthy lifestyles, even ... author Eli Puterman, PhD, assistant professor in the department ...
(Date:7/28/2014)... Pole in 1911, but new research shows that industrial ... data from 16 ice cores collected from widely spaced ... a group led by Joe McConnell of the Desert ... accurate and precise reconstruction to date of lead pollution ... an article published today in the online edition of ...
Breaking Biology News(10 mins):Unique images bring fossil insects back to life 2Healthy lifestyle may buffer against stress-related cell aging, study says 2Lead pollution beat explorers to South Pole, persists today 2Lead pollution beat explorers to South Pole, persists today 3
... German . , In male songbirds of ... in spring, which leads to an increase in song activity ... little evidence so far about such a clear relationship between ... lower degree of seasonal changes of the environment. Researchers of ...
... found that microscopic particles containing proteins and nucleic acids ... premature babies from serious lung diseases and chronic lung ... earlier research suggesting that while transplanting a kind of ... reduce lung injury and prevent inflammation in a mouse ...
... Spring Harbor, N.Y. Cancer cells grow fast. That,s an ... through all the cell-cycle checkpoints and are continuously growing and ... need to speed up their metabolism. CSHL Professor ... target the cancer cell metabolic process and in the process ...
Cached Biology News:Testosterone regulates solo song of tropical birds 2Microscopic packets of stem cell factors could be key to preventing lung disease in babies 2Microscopic packets of stem cell factors could be key to preventing lung disease in babies 3Team uses antisense technology that exploits gene splicing mechanism to kill cancer cells 2Team uses antisense technology that exploits gene splicing mechanism to kill cancer cells 3
(Date:7/29/2014)... EXpressLO LLC, expert provider of focused ... solutions, has been granted patent number 8,789,826 by the ... incorporating a unique specimen carrier support grid design described ... company patent for EXpressLO LLC awarded to founder and ... complementary patents extend EXpressLO’s portfolio of intellectual property. The ...
(Date:7/28/2014)... light, developed by researchers at the University of Cambridge, ... the realm of science fiction, such as invisibility cloaks ... be a reality for quite some time, the technique ... blocks a few billionths of a metre across can ... through them, and works on large chunks all at ...
(Date:7/28/2014)... 2014 The Workgroup for Electronic Data ... use of health IT to create efficiencies in healthcare ... (HPID) Workgroup has developed an issue brief titled, ... Payer?” The HPID Workgroup, a part of WEDI’s Strategic ... for Medicare and Medicaid Services (CMS) to identify common ...
(Date:7/28/2014)... July 28, 2014 According to ... Market Research "Regenerative Medicine (Bone and Joint) Market ... Tissue Engineering; By Applications - Bone Graft Substitutes, ... - Global Industry Analysis, Size, Share, Growth, Trends ... medicine (bone and joint) market was valued at ...
Breaking Biology Technology:EXpressLO LLC Granted Second U.S. Patent for Innovative Specimen Preparation Methods 2Building 'invisible' materials with light 2WEDI’s HPID Workgroup Announces Release of Issue Brief: “What is the Difference Between a Health Plan and Payer?” 2Regenerative Medicine Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 2Regenerative Medicine Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 3Regenerative Medicine Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 4
... lab that studies learning technologies with the University of Wisconsin and ... evening at the World Futurist Society meeting . The futurists ... at the Academic Advanced Distributed Learning Co-Lab , Brown will ... looking to video games as a teaching tool. Read more. ...
... Wisconsin Governor Jim Doyle and former Governor Tommy Thompson ... advantages of electronic health records, however, Doyle and Thompson ... two-year state budget includes $10 million in grants and ... health records, a move that could help harness the ...
... First Dolly, now human embryos. , ,This weeks announcement out ... who cloned Dolly the sheep, has been granted a license ... to spark fresh hopes among disease sufferers, scientists and advocacy ... amyotrophic lateral sclerosis (ALS). , ,These diseases could be addressed ...
Cached Biology Technology:Tech Digest: Futurists on learning; Sonic Foundry; Accu Tech; Fiserv 2Electronic health records can save lives and improve medical care 2Electronic health records can save lives and improve medical care 3Human cloning plans get blessing from British government 2Human cloning plans get blessing from British government 3
... system, 100-240 V, uses xMAP technology for ... proteins and peptides in one microplate well. ... to 100 color-coded bead sets, each of ... reactant (enzyme substrates, receptors, antigens, or antibodies) ...
Cell Culture Flask, 75 cm, treated polystyrene...
...
... These 50ml PYREX Delong style shaker ... to provide greater agitation of solutions to ... with rotary or reciprocating shakers. The long ... two-position polypropylene closures. Their uniform wall thickness ...
Biology Products: