Navigation Links
Frozen assets: NIAID researchers turn to unique resource for clues to norovirus evolution
Date:10/1/2009

omised immune system function, dehydration resulting from vomiting and diarrhea following norovirus infection can be life-threatening. In developing countries, according to a 2008 estimate by CDC researchers, up to 200,000 children under 5 years old die of norovirus infection each year. There is no vaccine against norovirus and no specific antiviral drugs to treat infections.

A key question for norovirus researchers is determining when a dominant variant, called genotype II.4 (or GII.4), first emerged, notes Dr. Green. "This genotype has been associated with the majority of global outbreaks of acute norovirus gastroenteritis since the mid-1990s," says Dr. Green. "The GII.4 genotype was first described around 1987, but no one knew for sure whether that genotype emerged then or if it existed earlier."

To answer the question, Dr. Bok customized a new techniquereal-time reverse transcriptase-polymerase chain reaction (RT-PCR)and applied it to stool samples originally collected from infants and young children hospitalized at the Children's National Medical Center in Washington, D.C., between 1974 and 1991. Samples were taken from infants and children with gastroenteritis and from others (controls) who did not have gastroenteritis. Essentially, Dr. Bok crafted genetic hooks capable of fishing out matching genetic sequences of any norovirus present in the samples. Fifty out of 5,424 samples tested contained norovirus. The most commonly seen genotype was GII.3 (48 percent), but the second most common genotype was GII.4 (16 percent). Some GII.4-containing specimens dated back to 1974, allowing the researchers to conclude that this now-dominant genotype had been circulating for years before its more recent identification as the cause of severe global outbreaks of norovirus disease.

Next, using a strategy developed by NIAID scientist Stanislav Sosnovtsev, Ph.D., the researchers determined the complete genetic sequences of five older GII.4 viruses and compared th
'/>"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Children born from frozen embryos weigh more and do better than those born after fresh transfer
2. A tiny frozen microbe may hold clues to extraterrestrial life
3. ICSI or IVF: Babies born from frozen embryos do just as well
4. NIAID announces grants to stimulate food allergy research
5. AVAC comments on NIAID decision not to move forward with PAVE 100 Trial
6. NIAID announces 25 new awards to develop radiation countermeasures
7. NIAID funds studies of how SARS and bird flu evade antiviral responses
8. NIAID scientists to speak on range of infectious disease topics at major scientific meeting
9. Researchers identify proteins involved in new neurodegenerative syndrome
10. Texas researchers and educators head for Antarctica
11. MGH researchers describe new way to identify, evolve novel enzymes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... elements are a key component of phloem, the conductive ... range of signalling molecules. Elongated cylindrical cells are capped ... end-to-end to form sieve tubes which in turn form ... "Sieve elements are very special cells which play an ... little has been known about their differentiation," says Professor ...
(Date:8/1/2014)... Fla. , Aug. 1, 2014  LiveScan Service Provider Binary Biometrics ... owner/operator team. As a result, Binary Biometrics will improve its mobile service capabilities ... Volusia County and service several new cities such as, ... , DeLand , Deltona , ... Helen , New Smyrna Beach , Oak ...
(Date:7/31/2014)... supported by the National Science Foundation (NSF), counters ... accelerates atmospheric warming, indicating instead that certain Arctic ... into the atmosphere. , The study, published ... focuses on thermokarst lakes, which occur as permafrost ... melted fresh water, converting what was previously frozen ...
Breaking Biology News(10 mins):Developmental regulation of important plant phloem components discovered 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 3Certain Arctic lakes store more greenhouse gases than they release 2
... On the first anniversary of the American Recovery and ... nation,s research universities today provided nearly 100 examples of ... paying outsize short- and long-term dividends for the nation. ... $21.5 billion is allocated for research and science infrastructure. ...
... Medical Inc. has obtained a non-exclusive license to ... property developed at Case Western Reserve University,s Department ... (FES) Center in Cleveland. ... manufacturer based in Indiana, Pa., rights to intramuscular ...
... multitude of questions, but sometimes traditional techniques are superior. ... cost, when they relied upon statistical data to monitor ... an indigenous group of people living in the James ... Montreal), have lived in harmony with their environment. They ...
Cached Biology News:Universities highlight benefits of stimulus research funding 2Universities highlight benefits of stimulus research funding 3Listen to the natives for better moose monitoring 2
(Date:7/31/2014)... people over 60 are not donor candidates for bone ... time, making the elderly prone to life-threatening infection and ... now has discovered a reason why. , "We have ... blood-forming cells to maintain blood production over time in ... could be restored for rejuvenation therapies," said Emmanuelle Passegu, ...
(Date:7/31/2014)... Ind. -- Chemists at Indiana University Bloomington have ... bricks-and-mortar fashion, a development with potential value for ... field-effect transistors and photovoltaic cells. , Their paper, ... Crystalline Solids and 2D Self-Assembled Crystals," has been ... journal of the Royal Society of Chemistry. It ...
(Date:7/31/2014)... Graphite Metallizing Corporation announces GRAPHALLOY® ... These bearings are uniquely suited to prevent loss of ... of the high temperatures . , Recently, a ... design engineers at Graphite Metallizing to overcome problems with ... manufacturing operation, pans containing blocks of powder mixture are ...
(Date:7/31/2014)... Francisco, California (PRWEB) July 31, 2014 ... systems that inform therapeutic decision-making in oncology, today announced ... August 14, 2014 to discuss the Company's financial results ... provide an update about the business in the current ... audio call beginning on Thursday, August 14, 2014, at ...
Breaking Biology Technology:Key to aging immune system is discovered 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 3Graphite Metallizing Announces Bearings for High Temperature Oven Applications 2Graphite Metallizing Announces Bearings for High Temperature Oven Applications 3CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2
... N.C., June 9, 2011 The David H. Murdock ... Immune Tolerance Institute, Inc. (ITI) as a next step ... the North Carolina Research Campus in Kannapolis, NC. Driven ... of breakthrough treatments for the range of immune-related diseases, ...
... all advanced a few steps closer to their future ... the week of May 9-13, 2011. That,s when ... three of the four robotics competitions at the IEEE ... China. The trio of contests are designed to prove ...
... 2011 Ronald W. Davis, PhD, a pioneer in innovative ... and genomic methods to biological organisms, will receive the 2011 ... Davis, 69, has spent most of his professional ... biochemistry and genetics. He also serves as director of the ...
Cached Biology Technology:David H. Murdock Research Institute Assumes Control of the Immune Tolerance Institute and Establishes a State of the Art Human Immune Monitoring Laboratory for Biomarker Discovery and Development 2David H. Murdock Research Institute Assumes Control of the Immune Tolerance Institute and Establishes a State of the Art Human Immune Monitoring Laboratory for Biomarker Discovery and Development 3NIST contests in China put next-gen robot technologies to the test 2NIST contests in China put next-gen robot technologies to the test 3Biochemist and Geneticist Ronald W. Davis Receives $500,000 Gruber Genetics Prize for Pioneering Work in the Development of Biotechnologies that Have Significantly Advanced the Fields of Molecular Genetics and Genomics 2Biochemist and Geneticist Ronald W. Davis Receives $500,000 Gruber Genetics Prize for Pioneering Work in the Development of Biotechnologies that Have Significantly Advanced the Fields of Molecular Genetics and Genomics 3
GlutaMAX-I Supplement...
Chemically Defined Lipid Concentrate...
... membrane-filtered isotonic and enzyme-free aqueous formulations ... agents in either Ca2+- and Mg2+-free ... Ca2+- and Mg2+-free phosphate-buffered saline for ... support substrates and each other for ...
... , 25 g Blocking Reagent , 2 x ... T7 Elution Buffer , 0.2 ml BL21 glycerol stock ... ml BLT5615 glycerol stock , 1010 pfu T7Select Positive ... , 50 l S-protein HRP Conjugate , 2 ...
Biology Products: