Navigation Links
Frozen assets: NIAID researchers turn to unique resource for clues to norovirus evolution
Date:10/1/2009

omised immune system function, dehydration resulting from vomiting and diarrhea following norovirus infection can be life-threatening. In developing countries, according to a 2008 estimate by CDC researchers, up to 200,000 children under 5 years old die of norovirus infection each year. There is no vaccine against norovirus and no specific antiviral drugs to treat infections.

A key question for norovirus researchers is determining when a dominant variant, called genotype II.4 (or GII.4), first emerged, notes Dr. Green. "This genotype has been associated with the majority of global outbreaks of acute norovirus gastroenteritis since the mid-1990s," says Dr. Green. "The GII.4 genotype was first described around 1987, but no one knew for sure whether that genotype emerged then or if it existed earlier."

To answer the question, Dr. Bok customized a new techniquereal-time reverse transcriptase-polymerase chain reaction (RT-PCR)and applied it to stool samples originally collected from infants and young children hospitalized at the Children's National Medical Center in Washington, D.C., between 1974 and 1991. Samples were taken from infants and children with gastroenteritis and from others (controls) who did not have gastroenteritis. Essentially, Dr. Bok crafted genetic hooks capable of fishing out matching genetic sequences of any norovirus present in the samples. Fifty out of 5,424 samples tested contained norovirus. The most commonly seen genotype was GII.3 (48 percent), but the second most common genotype was GII.4 (16 percent). Some GII.4-containing specimens dated back to 1974, allowing the researchers to conclude that this now-dominant genotype had been circulating for years before its more recent identification as the cause of severe global outbreaks of norovirus disease.

Next, using a strategy developed by NIAID scientist Stanislav Sosnovtsev, Ph.D., the researchers determined the complete genetic sequences of five older GII.4 viruses and compared th
'/>"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Children born from frozen embryos weigh more and do better than those born after fresh transfer
2. A tiny frozen microbe may hold clues to extraterrestrial life
3. ICSI or IVF: Babies born from frozen embryos do just as well
4. NIAID announces grants to stimulate food allergy research
5. AVAC comments on NIAID decision not to move forward with PAVE 100 Trial
6. NIAID announces 25 new awards to develop radiation countermeasures
7. NIAID funds studies of how SARS and bird flu evade antiviral responses
8. NIAID scientists to speak on range of infectious disease topics at major scientific meeting
9. Researchers identify proteins involved in new neurodegenerative syndrome
10. Texas researchers and educators head for Antarctica
11. MGH researchers describe new way to identify, evolve novel enzymes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... Genomes Project, aims to accelerate breeding for desired traits ... health and welfare. Results of the project,s first phase ... individual bulls whose direct descendants number in the tens ... Nature Genetics . , According to the researchers, breeding ... hereditary diseases and to improve the efficency of milk ...
(Date:7/22/2014)... challenges faced by researchers in modifying properties of nanomaterials ... simple technique, thanks to recent innovative studies conducted by ... Through the use of a simple, efficient and low ... research teams, led by Professor Sow Chorng Haur from ... Science, demonstrated that the properties of two different types ...
(Date:7/22/2014)... Cambridge, MA and Shenzhen, China July 22, ... Tech), a subsidiary of BGI, the world,s largest ... a new human whole exome sequencing service based ... service includes in-depth bioinformatics analysis and SNP validation, ... 31, 2014. , Complete Genomics, highly regarded ...
Breaking Biology News(10 mins):Whole-genome sequencing of bulls in key beef and dairy breeds 2NUS scientists use low cost technique to improve properties and functions of nanomaterials 2NUS scientists use low cost technique to improve properties and functions of nanomaterials 3BGI Tech launches human whole exome sequencing service on complete genomics' advanced platform 2
... identified a potential new therapeutic target that could be ... The study, published online ahead of print, ... . Specifically, the study reveals that two molecular pathways, ... that manipulating a protein called RBP-J involved in both ...
... November 2008 - Today, the European Molecular Biology Organization ... talented young researchers as 2008 beneficiaries of the EMBO ... the programme annually identifies the brightest and most promising ... scientific careers. Young group leaders receive a range of ...
... in Genome Research on Nov. 4, scientists at ... previously believed to be "junk" DNA is one of the ... 50 percent of human DNA has been referred to as ... A major source of these repeats is internal viruses that ...
Cached Biology News:New therapeutic target identified for rheumatoid arthritis 212 outstanding young scientists named as EMBO Young Investigators 2'Junk' DNA proves functional 2'Junk' DNA proves functional 3
(Date:7/22/2014)... China , 22 juli 2014 BGI ... BGI, ,s wereld grootste organisatie op het gebied van ... service ten behoeve van hele menselijke genoomsequentie via het ... In 2013 acquireerde BGI Complete Genomics, ... staat vanwege de in eigen beheer ontwikkelde sequentietechnologieën met ...
(Date:7/22/2014)...  The Broad Institute today announced an unprecedented ... Stanley aimed at galvanizing scientific research on ... molecular understanding to hundreds of millions of people ... commitment – the largest ever in psychiatric research ... general – will support research by a collaborative ...
(Date:7/22/2014)... Biofeedback – When a behavioral problem ... medication to best treat it can become a matter ... electroencephalography (EEG) can help predict which medicine will offer ... adverse drug events. , The article “Medication Prediction ... issue of the journal Biofeedback offers evidence that quantitative ...
(Date:7/21/2014)... to a chain of carbon atoms can turn it ... Rice University scientists. , Stretching the material known as ... -- by just 3 percent can begin to change ... for mechanically activated nanoscale electronics and optics. , The ... colleagues appears in the American Chemical Society journal ...
Breaking Biology Technology:BGI Tech introduceert service op gebied van hele menselijke exoomsequencing op geavanceerd Complete Genomics-platform 2$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 2$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 3$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 4$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 5$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 6$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 7$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 8$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 9$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 10Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 2Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 3Carbyne morphs when stretched 2Carbyne morphs when stretched 3
... 6, 2008 9:00 a.m. EDT, HOPKINTON, Mass., ... CALP ) will conduct a conference call discussing ... a.m. EDT on,Wednesday, August 6. Kevin Hrusovsky, President ... Officer, will host the call. Management,will discuss operational ...
... CEO,Andrew Witty comments on GSK,s second quarter results while also ... The new strategic priorities for GlaxoSmithKline are:, ... more products of value - Simplify GSK,s operating model, ... http://www.cantos.com . It,s free to view. All you need to ...
... 23 BioStorage Technologies, Inc.,(BST) will serve as ... the,Indiana Health Study, a new landmark longitudinal study ... utilize the,population of Indianapolis and surrounding areas as ... to new drugs and diagnostics that allow,doctors to ...
Cached Biology Technology:Caliper Life Sciences' Second Quarter 2008 Financial Results Conference Call Notice 2BioStorage Technologies Serves as Repository for Landmark Study of Coronary Artery Disease 2
... The TUNEL-based assay kit provides complete components ... convenient detection of DNA fragmentation in cultured ... BrdU in the procedure provides greater sensitivity ... be analyzed by flow cytometry. The kit ...
Packaging: package with 500 l Patent/trademark/license (electronic): (r) Registered trademark of Molecular Probes...
... excellent ion chromatography system . The sensitive ... 0.01S to 5000S, houses the measuring cell in ... 4715, is available. Data processing is provided ... delivery is by the high pressure CE 4100 ...
The Mu-End™ Protein Truncation Kit provides a convenient method for generating a library of N-terminal and C-terminal protein deletions that can be expressed in E. coli....
Biology Products: