Navigation Links
From the clinics to the bench and back -- phenytoin as a mood stabilizer?
Date:3/29/2010

This release is available in Chinese.

Phenytoin is a well known antiepileptic agent widely used throughout the world. Recent clinical studies in patients with bipolar disorder have suggested that, as for other anticonvulsant drugs commonly used in the treatment of bipolar patients including valproate and carbamazepine, phenytoin may have mood-stabilizing effects in addition to its well-known anticonvulsant properties. In a study published in the March 2010 issue of Experimental Biology and Medicine Veronica Mariotti and colleagues utilized DNA microarrays to investigate the molecular underpinnings of the potential mood-stabilizing action of phenytoin by looking at its effect on gene expression in the rat brain.

As compared with untreated animals, rats treated for a month with phenytoin had 508 differentially expressed genes in the hippocampus and 62 in the frontal cortex, including genes involved in GABAergic and glutamatergic neurotransmission, neuroprotection and other genes thought to be crucial for mood regulation. Furthermore, some of these same genes have been shown to be modulated by classical mood-stabilizer agents, like lithium and valproate.

Thus, the findings of this study indicate that chronic phenytoin administration modulates the expression of genes involved in mood regulation and genes that are targets of established mood stabilizers. Dr Mariotti noted that "The results of this study provide preliminary insights into possible molecular mechanisms of action of phenytoin as a potential mood stabilizer and, more in general, the pathophysiology of bipolar disorders".

The study is the product of a fruitful collaboration between the Molecular Biology Laboratory of Dr. Silvia Pellegrini at the Department of Experimental Pathology, University of Pisa Medical School, Pisa, Italy and the Laboratory of Professors Galila
'/>"/>

Contact: Dr. Silvia Pellegrini
silvia.pellegrini@bioclinica.unipi.it
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Titanium Group Announces Biometric Contract with One of the Most Active Clinics in Hong Kong
2. UC Davis bench-to-bedside research: Promising treatment in clinical trials
3. Animal models that help translate regenerative therapies from bench to bedside
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... AZ, Sept. 18, 2014 -- Arizona turned its newborn ... just a few short months, earning it the first-ever Newborn ... The March of Dimes presented Will Humble, M.P.H., Arizona,s Department ... held here today. Mr. Humble established a policy of full ... to send newborn blood samples to the lab for analysis, ...
(Date:9/18/2014)... will be celebrated tonight at the third annual Golden ... health of premature infants and in paving the way ... work was supported by the National Science Foundation, the ... Commission, will be honored at a ceremony at the ... of Members of Congress will be on hand to ...
(Date:9/18/2014)... September 18, 2014 Elsevier, a world-leading provider ... services, and the Australasian Research Management Society (ARMS), ... scientists at the 5th Scopus Young Researcher of ... earlier today at the National Convention Centre and ... was attended by guests representing Australia,s and New ...
Breaking Biology News(10 mins):March of Dimes honors Arizona with first-ever newborn screening award 2March of Dimes honors Arizona with first-ever newborn screening award 33rd annual Golden Goose award ceremony honors 8 researchers; Unusual work had big results 2Elsevier and Australasian Research Management Society award scientists at Scopus ceremony 2
... fluctuations in the populations they target, but its not ... journal Nature by scientists at Scripps Institution of Oceanography ... general underlying mechanism. Research led at Scripps with ... two chief scientific advisors to the United Kingdom) demonstrates ...
... worm, University of Maryland researchers have discovered an important ... absorbed and transported into the body. The finding could ... the worlds number one nutritional disorder., With C. elegans, ... Hamza, assistant professor of animal and avian sciences, and ...
... -- Some primates have evolved big brains because their ... advantage that outweighs the demands of extra years of ... Duke University and the University of Zurich have concluded ... key benchmarks in the development of 28 different primate ...
Cached Biology News:Fishing throws targeted species off balance, Scripps study shows 2Fishing throws targeted species off balance, Scripps study shows 3Bloodless worm sheds light on human blood, iron deficiency 2Bloodless worm sheds light on human blood, iron deficiency 3Slowly-developing primates definitely not dim-witted 2Slowly-developing primates definitely not dim-witted 3
(Date:9/18/2014)... D.C. (PRWEB) September 18, 2014 On ... Durbin and Sen. Jim Risch for National Lab Day ... projects from across the national laboratory system. Durbin and ... which aims to increase awareness of the reach of ... technologies and discoveries to address some of our nation's ...
(Date:9/18/2014)... -- Research and Markets has announced ... Report 2014" report to their offering. ... is a professional and in-depth study on the ... The report provides a basic overview of ... chain structure. The N-acetylcysteine market analysis is provided ...
(Date:9/18/2014)... DUBLIN , Sept. 18, 2014 ... the "Global Companion Diagnostics (Polymerase Chain Reaction, In-situ ... report to their offering. The ... a CAGR of 22.7% from 2014 to 2019. Factors ... treatment, growing adoption of companion diagnostics by the pharmaceutical ...
(Date:9/18/2014)... Sept. 18, 2014  U.S. biotech company Kultevat ... exclusive license for technology developed by the Donald ... in plants, including for applications in production of natural ... The technology was developed under the direction of ... and former president of the Danforth Plant Science Center, ...
Breaking Biology Technology:Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3Global N-acetylcysteine Industry Report 2014 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 3Kultevat obtains license of gene switch technology 2
... my wishes are,coming true," says Kristin Shumpert, who is traveling from ... of Las,Vegas ... and to meet the people who "saved my ... held little interest to the young,woman who suffers from a devastating ... time to use the ladies, room. , ...
... Integrated Knowledge Center Outside the United States. , ... ... Knowledge Center (DKC) today, 17 months after breaking ground last summer. ... the city’s Genome Valley, the center will be a research hub ...
... commercial life sciences sales experience to Cyntellect , ... a privately-held life sciences company leading the development and commercialization ... it has appointed Andre Lubarsky as the Company,s Director of ... sales of Cyntellect,s cell purification and cell health products in ...
Cached Biology Technology:Noninvasive Medical Technologies Helps Make Young Tennessee Woman's Wishes Come True 2Noninvasive Medical Technologies Helps Make Young Tennessee Woman's Wishes Come True 3Noninvasive Medical Technologies Helps Make Young Tennessee Woman's Wishes Come True 4Noninvasive Medical Technologies Helps Make Young Tennessee Woman's Wishes Come True 5DuPont Opens Research & Development Center in India 2DuPont Opens Research & Development Center in India 3Cyntellect Appoints Former BD Biosciences Executive Andre Lubarsky as Director of Sales - North America 2
Mouse monoclonal antibody to Lats2....
... (eIF4E-binding protein II) is involved in translation ... kidney. PHAS proteins bind to eIF-4E, the ... capped mRNA in vitro and in cells. ... of PHAS/eIF-4E complexes. This allows eIF-4E to ...
MAb to HSV-2, gG-2 HSV-2 Glycoprotein G-2...
... INK4a-ARF locus encodes two unrelated proteins both ... arrests the cell cycle in a p53-dependent ... the rapid degradation of mdm2 proteinrequired for ... accumulation. This interaction is mediated by ...
Biology Products: