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From surgery to laboratory and back again
Date:2/11/2014

reversing the effect of heparin and allowing clotting to begin.

Importantly, the system is biodegradable unless bound to heparin, with the molecules slowly breaking down, leading to nanostructure disassembly and inactivation. This means that, in principle, plenty of this compound could be used, because any excess will be less likely to cause side effects.

Professor Smith adds: "This could revolutionise the way in which surgeons reverse the effects of heparin once surgery is complete. I call this 'self-assembled multivalent' approach to medicine as 'SAMul' nanomedicine in honour of Sam who gave me the initial inspiration."

The next stages of the research will involve further optimisation of the agents to maximise their binding and further minimise their toxicity prior to in vivo testing and eventual clinical trials.


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Contact: David Garner
david.garner@york.ac.uk
44-019-043-22153
University of York
Source:Eurekalert

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