Navigation Links
From surgery to laboratory and back again
Date:2/11/2014

A University of York scientist's experience in seeing his partner in hospital recovering from a double lung transplant prompted him to design and synthesise new chemical agents that could revolutionise post-operative patient care.

Professor Dave Smith, of the University's Department of Chemistry, led an international team which developed the agents that bind and potentially remove the anti-coagulant heparin.

Professor Smith says: 'I was sitting at my husband Sam's bedside while he recovered from a double lung transplant when the idea first came to me. I spent a long time talking to surgeons about all the drugs they used, and some of the problems they caused, and as I sat there, looking at all the tubes, I realised that perhaps my research team could help."

One of the drugs used during major surgery is heparin which helps to prevent the blood from clotting. Once the patient is in recovery, however, the surgeons want clotting to resume to aid the healing process. To do this they use a 'heparin rescue agent', called protamine, to remove heparin from the patient's bloodstream. But in some cases, this can cause side effects such as patients going into anaphylactic shock. As a result, doctors must use protamine cautiously, which can lead to inefficient clotting.

"I realised that my research group had developed expertise which could lead to chemical agents to bind, and perhaps remove the heparin. These chemical agents can be carefully designed to minimise side effects and so improve patient care," Professor Smith says.

He designs small drug-like molecules, which assemble spontaneously into larger nanostructures in order to bind the heparin using multivalent (many-bonds) interactions. In the latest research, published in Chemical Science, Professor Smith and his team, which includes researchers from University of Liverpool, University of Trieste, and Freie Universitt Berlin demonstrate that this approach works in vitro in human plasma,
'/>"/>

Contact: David Garner
david.garner@york.ac.uk
44-019-043-22153
University of York
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gastric banding patients should closely monitor nutrition following surgery
2. Using morphine after abdominal surgery may prolong pain, CU-Boulder researchers find
3. Findings announced from landmark study on safety of adolescent bariatric surgery
4. Parkinsons Surgery Research wins NSF Grant
5. Breast cancer surgery linked to swollen arm syndrome
6. Chris Christie, Governor of New Jersey, Slims Down after Having Lap Band Surgery
7. Research shows Vitamin D levels drop after pediatric heart surgery, increasing sickness
8. Improved material for laser welding of tissue in intestinal surgery
9. Study finds possible alternative to bariatric weight loss surgery
10. What you eat before surgery may affect your recovery
11. Physical activity linked to lower rates of depression in bariatric surgery patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2014)... professor of mechanical engineering at Worcester Polytechnic ... university,s Integrative Materials Design Center (iMdc), recently ... leading engineering societies. , At its annual ... association of more than 138,000 engineers and ... and commercial vehicle industries, presented Lados with ...
(Date:4/15/2014)... the question of how social behavior has developed over ... Mainz and Basel have gained new insights from the ... for food. Rather the siblings share what is available ... Dr. Jol Meunier of the Evolutionary Biology section of ... Mainz (JGU). The team of biologists from Mainz University ...
(Date:4/15/2014)... Sciences (KNAW) has announced the names of five internationally ... (one million US dollars prize money in total). The ... to science. , This year marks the 50th anniversary ... chemist Erwin Chargaff in 1964. , KNAW juries ... laureates: , Christopher M. Dobson, John Humphrey ...
Breaking Biology News(10 mins):WPI's Diana Lados honored by SAE International and Minerals, Metals, and Materials Society 2WPI's Diana Lados honored by SAE International and Minerals, Metals, and Materials Society 3WPI's Diana Lados honored by SAE International and Minerals, Metals, and Materials Society 4WPI's Diana Lados honored by SAE International and Minerals, Metals, and Materials Society 5Sibling cooperation in earwig families gives clues to early evolution of social behavior 2Five scientists awarded prestigious Heineken Prizes 2
... Medical mycologists in The South Texas Center for Emerging ... The University of Texas at San Antonio (UTSA) have ... a respiratory infection of humans, commonly called Valley Fever, ... For the first time, the researchers have genetically ...
... Survey have collected individuals from a wide range of species ... levels of water temperature to learn how each species is ... to experience in the future. The study showed that several ... upper temperature range, and that further increases caused by global ...
... LAFAYETTE, Ind. - Catching adult eagles for research purposes is ... a way around the problem, and, in the process, gathered ... hand on one. "Many birds are small, easy to ... and natural resources. "With eagles, the effort can be 100 ...
Cached Biology News:UTSA infectious disease researchers advancing vaccine against Valley fever 2Scientists are learning more about big birds from feathers 2
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... body, then alarm bells start ringing. Such clumps, ... type 2 diabetes, formerly called adult-onset diabetes. If ... might be able to treat such diseases more efficiently. ... the Helmholtz-Zentrum Dresden-Rossendorf and the university in Aarhus, Denmark, ...
... The Plasma Protein Therapeutics Association (PPTA) applauds the ... Drugs Act ( H.R. 2672 ) and ( S. ... therapies that treat patients with rare diseases by eliminating barriers ... on plasma protein therapies are coping with a very rare ...
... (NASDAQ: GPRO ) today reported financial results for ... million and non-GAAP earnings per share (EPS) of $0.51.   ... products in the second quarter of 2011, while supply chain ... sales a year ago," said Carl Hull, the Company,s president ...
Cached Biology Technology:In the pursuit of dangerous clumps 2In the pursuit of dangerous clumps 3PPTA Praises Legislation That Protects the Treatment of Rare Diseases 2Gen-Probe Reports Financial Results for the Second Quarter of 2011 2Gen-Probe Reports Financial Results for the Second Quarter of 2011 3Gen-Probe Reports Financial Results for the Second Quarter of 2011 4Gen-Probe Reports Financial Results for the Second Quarter of 2011 5Gen-Probe Reports Financial Results for the Second Quarter of 2011 6Gen-Probe Reports Financial Results for the Second Quarter of 2011 7Gen-Probe Reports Financial Results for the Second Quarter of 2011 8Gen-Probe Reports Financial Results for the Second Quarter of 2011 9Gen-Probe Reports Financial Results for the Second Quarter of 2011 10Gen-Probe Reports Financial Results for the Second Quarter of 2011 11Gen-Probe Reports Financial Results for the Second Quarter of 2011 12Gen-Probe Reports Financial Results for the Second Quarter of 2011 13Gen-Probe Reports Financial Results for the Second Quarter of 2011 14
Request Info...
... BioPrime Plus Array CGH Genomic Labeling Systems ... reproducible labeling of genomic DNA samples for ... both indirect and direct labeling formats, the ... provide a flexible solution to your genomic ...
We offer solid and solution phase peptide synthesis including a whole range of modifications. Please send the details of your peptide synthesis need to info@rpeptide.com...
... - Monolayer is a system designed for ... in a serum-free environment. The kit contains a ... been optimized for neural stem cell expansion (Johe, ... Development 10 :3129). Human fibroblast growth factor ...
Biology Products: